CA2550117A1 - Nouvelles disruptions geniques, compositions et procedes associes - Google Patents
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- CA2550117A1 CA2550117A1 CA002550117A CA2550117A CA2550117A1 CA 2550117 A1 CA2550117 A1 CA 2550117A1 CA 002550117 A CA002550117 A CA 002550117A CA 2550117 A CA2550117 A CA 2550117A CA 2550117 A1 CA2550117 A1 CA 2550117A1
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| KR101008758B1 (ko) | 2001-09-18 | 2011-01-14 | 제넨테크, 인크. | 종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물 |
| US20060099608A1 (en) * | 2004-03-29 | 2006-05-11 | Medstar Research Institute | Methods of diagnosing cardiovascular disease |
| WO2006017673A2 (fr) | 2004-08-03 | 2006-02-16 | Biogen Idec Ma Inc. | Influence du taj sur les fonctions neuronales |
| AU2005280266A1 (en) | 2004-08-25 | 2006-03-09 | Genentech, Inc. | Novel gene disruptions, compositions and methods relating thereto |
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| US20080311107A1 (en) * | 2006-02-17 | 2008-12-18 | Genetech, Inc. | Novel Gene Disruptions, Compositions and Methods Relating Thereto |
| WO2008091888A2 (fr) * | 2007-01-23 | 2008-07-31 | Lexicon Pharmaceuticals, Inc. | Nouvelles disruptions géniques, compositions et procédés associés |
| WO2009105709A1 (fr) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systèmes et procédés pour traiter, transmettre et afficher des données de détecteur |
| US9879267B2 (en) * | 2008-03-14 | 2018-01-30 | Genentech, Inc. | Genetic variations associated with drug resistance |
| DK2251454T3 (da) | 2009-05-13 | 2014-10-13 | Sio2 Medical Products Inc | Coating og inspektion af beholder |
| US9878101B2 (en) | 2010-11-12 | 2018-01-30 | Sio2 Medical Products, Inc. | Cyclic olefin polymer vessels and vessel coating methods |
| US9901616B2 (en) | 2011-08-31 | 2018-02-27 | University Of Georgia Research Foundation, Inc. | Apoptosis-targeting nanoparticles |
| AU2012318242A1 (en) | 2011-11-11 | 2013-05-30 | Sio2 Medical Products, Inc. | Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus |
| US10416167B2 (en) | 2012-02-17 | 2019-09-17 | University Of Georgia Research Foundation, Inc. | Nanoparticles for mitochondrial trafficking of agents |
| WO2014078666A1 (fr) | 2012-11-16 | 2014-05-22 | Sio2 Medical Products, Inc. | Procédé et appareil pour détecter des caractéristiques d'intégrité de revêtement de barrière rapide |
| EP2925903B1 (fr) | 2012-11-30 | 2022-04-13 | Si02 Medical Products, Inc. | Contrôle de l'uniformité de dépôt chimique en phase vapeur activé par plasma (pecvd) sur des seringues médicales, des cartouches et analogues |
| US9764093B2 (en) | 2012-11-30 | 2017-09-19 | Sio2 Medical Products, Inc. | Controlling the uniformity of PECVD deposition |
| EP2961858B1 (fr) | 2013-03-01 | 2022-09-07 | Si02 Medical Products, Inc. | Seringue revetu. |
| US9937099B2 (en) | 2013-03-11 | 2018-04-10 | Sio2 Medical Products, Inc. | Trilayer coated pharmaceutical packaging with low oxygen transmission rate |
| EP2792742A1 (fr) | 2013-04-17 | 2014-10-22 | Universitätsklinikum Hamburg-Eppendorf (UKE) | Vecteurs de thérapie génique permettant de traiter la myocardiopathie |
| US10398663B2 (en) | 2014-03-14 | 2019-09-03 | University Of Georgia Research Foundation, Inc. | Mitochondrial delivery of 3-bromopyruvate |
| EP3693493A1 (fr) | 2014-03-28 | 2020-08-12 | SiO2 Medical Products, Inc. | Revêtements antistatiques pour récipients en plastique |
| EP3115784A1 (fr) * | 2015-07-10 | 2017-01-11 | Koss, Michael Janusz | Marqueur polypeptidique pour l'analyse, le diagnostic et le traitement de maladies oculaires |
| CN106797916A (zh) * | 2017-01-24 | 2017-06-06 | 黄山市休宁县珍稀水生动物研究所 | 一种平胸龟养殖方法 |
| EP3601534A1 (fr) * | 2017-03-29 | 2020-02-05 | Stichting Sanquin Bloedvoorziening | Isolement de cellules (t) régulatrices stables et leurs utilisations |
| CN110692594B (zh) * | 2019-10-12 | 2021-12-24 | 上海交通大学 | 一种人血管瘤动物模型及其高成功率构建方法 |
| CN111742883B (zh) * | 2020-01-03 | 2022-02-18 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | 一种肺脾气虚证变应性鼻炎病证结合动物模型的构建方法 |
| CN113080136B (zh) * | 2021-02-24 | 2022-05-17 | 厦门大学 | 一种腹膜后肉瘤小鼠原位异种移植动物模型的建立方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6899882B1 (en) | 1989-03-24 | 2005-05-31 | The Regents Of The University Of California | Endothelial cell growth factor methods of isolation and expression |
| JP2001516580A (ja) * | 1997-09-17 | 2001-10-02 | ジェネンテック・インコーポレーテッド | 分泌性の、および膜貫通性のポリぺプチド、およびそれをコードする核酸 |
| US6436707B1 (en) | 1998-03-27 | 2002-08-20 | Lexicon Genetics Incorporated | Vectors for gene mutagenesis and gene discovery |
| US6051690A (en) * | 1998-04-23 | 2000-04-18 | Genentech, Inc. | NSP molecules |
| IL139219A0 (en) * | 1998-04-24 | 2001-11-25 | Genentech Inc | Fizz proteins |
| AU783897B2 (en) * | 1999-09-24 | 2005-12-22 | Lexicon Genetics Incorporated | Novel human protease inhibitor-like proteins and polynucleotides encoding the same |
| AU3434601A (en) * | 1999-11-30 | 2001-06-12 | Genentech Inc. | Compositions and methods for the treatment of immune related diseases |
| AU2001264579B2 (en) | 2000-05-12 | 2006-04-06 | Lexicon Pharmaceuticals, Inc. | Seven transmembrane proteins and polynucleotides encoding the same |
| AU6531101A (en) * | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| AU2002239538A1 (en) * | 2000-12-06 | 2002-06-18 | Deltagen, Inc. | Transgenic mice containing glucagon receptor gene disruptions |
| US20040067553A1 (en) | 2000-12-28 | 2004-04-08 | Masanori Miwa | Novel g protein-coupled receptor protein and dna thereof |
| US7164055B2 (en) * | 2001-06-26 | 2007-01-16 | Deltagen, Inc. | HSPC150-like gene disruptions, compositions and methods related thereto |
| US20050233954A1 (en) * | 2002-04-08 | 2005-10-20 | Eli Lilly And Company | Use of resistin to treat hematopoietic disorders |
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2004
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- 2004-12-13 WO PCT/US2004/041721 patent/WO2005058028A2/fr not_active Ceased
- 2004-12-13 AU AU2004299044A patent/AU2004299044B2/en not_active Ceased
- 2004-12-13 JP JP2006545780A patent/JP2007518404A/ja active Pending
- 2004-12-13 EP EP04813966A patent/EP1694116A2/fr not_active Withdrawn
- 2004-12-13 ZA ZA200801231A patent/ZA200801231B/en unknown
- 2004-12-13 CA CA002550117A patent/CA2550117A1/fr not_active Abandoned
- 2004-12-13 ZA ZA200605822A patent/ZA200605822B/xx unknown
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| EP1694116A2 (fr) | 2006-08-30 |
| AU2004299044B2 (en) | 2008-10-30 |
| AU2004299044A1 (en) | 2005-06-30 |
| ZA200801230B (en) | 2009-05-27 |
| ZA200801231B (en) | 2009-05-27 |
| WO2005058028A2 (fr) | 2005-06-30 |
| WO2005058028A3 (fr) | 2006-05-18 |
| US8067664B2 (en) | 2011-11-29 |
| ZA200605822B (en) | 2009-05-27 |
| AU2008234961A1 (en) | 2008-11-13 |
| US20120174239A1 (en) | 2012-07-05 |
| ZA200801235B (en) | 2009-05-27 |
| US20070292438A1 (en) | 2007-12-20 |
| JP2007518404A (ja) | 2007-07-12 |
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