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CA2435415A1 - Microparticules de polymere biodegradable encapsulant une substance biologiquement active et formulations pharmaceutiques a liberation prolongee contenant lesdites particules - Google Patents

Microparticules de polymere biodegradable encapsulant une substance biologiquement active et formulations pharmaceutiques a liberation prolongee contenant lesdites particules Download PDF

Info

Publication number
CA2435415A1
CA2435415A1 CA002435415A CA2435415A CA2435415A1 CA 2435415 A1 CA2435415 A1 CA 2435415A1 CA 002435415 A CA002435415 A CA 002435415A CA 2435415 A CA2435415 A CA 2435415A CA 2435415 A1 CA2435415 A1 CA 2435415A1
Authority
CA
Canada
Prior art keywords
microparticles
water
active substance
organic
biologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002435415A
Other languages
English (en)
Inventor
Piero Orsolini
Evelyne Vuaridel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debio Recherche Pharmaceutique SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CH2001/000064 external-priority patent/WO2002058671A1/fr
Application filed by Individual filed Critical Individual
Publication of CA2435415A1 publication Critical patent/CA2435415A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne de nouvelles microparticules de polymère biodégradable encapsulant une substance biologiquement active soluble ou insoluble dans l'eau, un procédé de préparation de ces microparticules, et une formulation pharmaceutique à libération prolongée sans éclatement comprenant lesdites microparticles.
CA002435415A 2001-01-26 2002-01-28 Microparticules de polymere biodegradable encapsulant une substance biologiquement active et formulations pharmaceutiques a liberation prolongee contenant lesdites particules Abandoned CA2435415A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/CH2001/000064 WO2002058671A1 (fr) 2001-01-26 2001-01-26 Microparticules pharmaceutiques exemptes d"eclatement
CHPCT/CH01/00064 2001-01-26
IB0101370 2001-07-31
IBPCT/IB01/01370 2001-07-31
PCT/CH2002/000048 WO2002058672A2 (fr) 2001-01-26 2002-01-28 Microparticules de polymere biodegradable encapsulant une substance biologiquement active et formulations pharmaceutiques a liberation prolongee contenant lesdites particules

Publications (1)

Publication Number Publication Date
CA2435415A1 true CA2435415A1 (fr) 2002-08-01

Family

ID=25705676

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002435415A Abandoned CA2435415A1 (fr) 2001-01-26 2002-01-28 Microparticules de polymere biodegradable encapsulant une substance biologiquement active et formulations pharmaceutiques a liberation prolongee contenant lesdites particules

Country Status (2)

Country Link
CA (1) CA2435415A1 (fr)
WO (1) WO2002058672A2 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2516107C (fr) 2003-04-10 2013-12-24 Ehud Zeigerson Procede de production de microparticules a base d'emulsion
WO2005009356A2 (fr) 2003-07-15 2005-02-03 Pr Pharmaceuticals, Inc. Procede de preparation de compositions a liberation controlee
WO2005009357A2 (fr) * 2003-07-23 2005-02-03 Pr Pharmaceuticals, Inc. Compositions a liberation controlee
DK1682537T3 (da) 2003-11-05 2012-07-09 Sarcode Bioscience Inc Modulatorer af celleadhæsion
FR2865938B1 (fr) * 2004-02-05 2006-06-02 Sod Conseils Rech Applic Formulation retard solide comprenant de l'acetate de triptoreline
FR2869801B1 (fr) * 2004-05-05 2008-09-12 Ethypharm Sa Procede de preparation de compositions a liberation prolongee et utilisation de ces compositions pour le traitement des affections chroniques du systeme nerveux central (snc)
EP2444079B1 (fr) 2005-05-17 2016-11-30 SARcode Bioscience Inc. Compositions et procédés pour le traitement des troubles de l'oeil
AU2007303794A1 (en) * 2006-10-05 2008-04-10 Panacea Biotec Ltd. Injectable depot composition and its' process of preparation
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (fr) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2702984C (fr) 2007-10-19 2017-04-11 Sarcode Corporation Compositions et procedes pour le traitement de la retinopathie diabetique
US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
EP2810951B1 (fr) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
WO2011050175A1 (fr) 2009-10-21 2011-04-28 Sarcode Corporation Agent pharmaceutique cristallin et procédés de préparation et utilisation de celui-ci
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2705013B1 (fr) 2011-05-04 2016-03-30 Balance Therapeutics, Inc. Dérivés de pentylènetétrazole
WO2014018748A1 (fr) 2012-07-25 2014-01-30 Sarcode Bioscience Inc. Inhibiteur de lfa-1 et polymorphe de celui-ci
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
CN106061494A (zh) 2013-10-10 2016-10-26 辛纳吉制药公司 可用于治疗阿片样物质诱导的功能障碍的鸟苷酸环化酶的激动剂
CA3009814A1 (fr) 2016-01-11 2017-07-20 Synergy Pharmaceuticals, Inc. Formulations et methodes pour traiter la rectocolite hemorragique
IT202000017191A1 (it) 2020-07-15 2022-01-15 Xbrane Biopharma Ab Procedimento senza acqua per preparare una composizione farmaceutica per un rilascio più prolungato e controllato di triptorelina o di un suo sale

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
EP1044683A1 (fr) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. Procédé de dispersion à une étape pour la microencapsulation de substances solubles dans l'eau
US20040126431A1 (en) * 2000-10-03 2004-07-01 Frederic Lagarce Method for preparing microspheres containing a water-soluble substance
WO2002058671A1 (fr) * 2001-01-26 2002-08-01 Debio Recherche Pharmaceutique S.A. Microparticules pharmaceutiques exemptes d"eclatement

Also Published As

Publication number Publication date
WO2002058672A3 (fr) 2002-12-19
WO2002058672A2 (fr) 2002-08-01

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Legal Events

Date Code Title Description
FZDE Discontinued