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CA2435492A1 - Composes antithrombotiques, leur preparation et leur utilisation comme produits pharmaceutiques - Google Patents

Composes antithrombotiques, leur preparation et leur utilisation comme produits pharmaceutiques Download PDF

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Publication number
CA2435492A1
CA2435492A1 CA002435492A CA2435492A CA2435492A1 CA 2435492 A1 CA2435492 A1 CA 2435492A1 CA 002435492 A CA002435492 A CA 002435492A CA 2435492 A CA2435492 A CA 2435492A CA 2435492 A1 CA2435492 A1 CA 2435492A1
Authority
CA
Canada
Prior art keywords
group
denotes
carbonyl
alkyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002435492A
Other languages
English (en)
Inventor
Uwe Joerg Ries
Henning Priepke
Herbert Nar
Jean-Marie Stassen
Wolfgang Wienen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10104597A external-priority patent/DE10104597A1/de
Application filed by Individual filed Critical Individual
Publication of CA2435492A1 publication Critical patent/CA2435492A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne des composés antithrombotiques de formule générale (1) dans laquelle R1 à R4, Ar, A, m et n sont tels que définis dans la revendication 1, leurs tautomères, leurs stéréoisomères, leurs mélanges, leurs promédicaments et leurs sels, qui ont des propriétés intéressantes. Les composés de la formule 1 indiquée ci-dessus, dans lesquels Ar est un groupe phényle ou naphtyle substitué par les radicaux R5, R6 et R7 et R5 est un groupe cyano, correspondent à des produits intermédiaires intéressants permettant la production de composés correspondants de formule générale 1, dans lesquels R5 est un groupe aminido éventuellement substitué par un ou deux groupes alkyle en C1-3. Les composés de formule générale 1 indiquée ci-dessus, à l'exception des composés dans lesquels Ar est un groupe phényle ou naphtyle substitué par les radicaux R5, R6 et R7 et R5 est un groupe cyano, ont des propriétés pharmacologiques intéressantes, notamment une action antithrombotique et une action d'inhibition de facteur Xa.
CA002435492A 2001-02-02 2002-01-26 Composes antithrombotiques, leur preparation et leur utilisation comme produits pharmaceutiques Abandoned CA2435492A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10104597A DE10104597A1 (de) 2001-02-02 2001-02-02 Antithrombotische Verbindungen, deren Herstellung und deren Verwendung als Arzneimittel
DE10104597.2 2001-02-02
DE10135435.0 2001-07-26
DE10135435 2001-07-26
PCT/EP2002/000823 WO2002062778A2 (fr) 2001-02-02 2002-01-26 Composes antithrombotiques, leur preparation et leur utilisation comme produits pharmaceutiques

Publications (1)

Publication Number Publication Date
CA2435492A1 true CA2435492A1 (fr) 2002-08-15

Family

ID=26008392

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002435492A Abandoned CA2435492A1 (fr) 2001-02-02 2002-01-26 Composes antithrombotiques, leur preparation et leur utilisation comme produits pharmaceutiques

Country Status (5)

Country Link
EP (1) EP1390357A2 (fr)
JP (1) JP2004522759A (fr)
CA (1) CA2435492A1 (fr)
MX (1) MXPA03006648A (fr)
WO (1) WO2002062778A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9925174B2 (en) 2002-03-07 2018-03-27 Boehringer Ingelheim International Gmbh Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonyl-amino-imino-methyl)-phenylamino]-methyl}-1-methyl-1 H-benzimidazol acid ethyl ester and the salts thereof

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10234058A1 (de) * 2002-07-26 2004-02-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Benzoesäureamide, deren Herstellung und deren Verwendung als Arzneimittel
CN1703395A (zh) * 2002-08-09 2005-11-30 特兰斯泰克制药公司 芳基和杂芳基化合物以及调节凝血的方法
US7247654B2 (en) 2003-06-04 2007-07-24 Bristol-Myers Squibb Company 3,4-disubstituted benzamidines and benzylamines, and analogues thereof, useful as serine protease inhibitors
US7570259B2 (en) 2004-06-01 2009-08-04 Intel Corporation System to manage display power consumption
KR20070047338A (ko) * 2004-09-06 2007-05-04 에프. 호프만-라 로슈 아게 4-아미노메틸 벤즈아미딘 유도체 및 그의 ⅶａ 인자억제제로서의 용도
DE602005009252D1 (de) 2004-12-08 2008-10-02 Bristol Myers Squibb Co Heterocyclische verbindungen als inhibitoren von faktor viia
ES2566481T3 (es) 2006-04-12 2016-04-13 Merck Sharp & Dohme Corp. Antagonistas del canal de calcio de tipo T de piridil amida
RU2010120671A (ru) 2007-10-24 2011-11-27 Мерк Шарп Энд Домэ Корп. (Us) Гетероциклические фениламидные антагонисты кальциевых каналов т-типа
KR20250004174A (ko) 2014-06-27 2025-01-07 노그라 파마 리미티드 아릴 수용체 조정제, 및 그의 제조 및 사용 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD142804A3 (de) * 1977-11-07 1980-07-16 Wagner Guenter Verfahren zur herstellung von na-alkyl-bzw.na-aryl-sulfonylierten omega-amidinophenyl-alpha-aminoalkylcarbonsaeureamiden
EP0654465A1 (fr) * 1993-11-15 1995-05-24 Ciba-Geigy Ag Polyamino-polyamides
US5741819A (en) * 1995-06-07 1998-04-21 3-Dimensional Pharmaceuticals, Inc. Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors
WO2000056707A1 (fr) * 1999-03-24 2000-09-28 Sepracor, Inc. Thioethers de diaryle, compositions et utilisations de ces dernieres
WO2001010823A1 (fr) * 1999-08-07 2001-02-15 Boehringer Ingelheim Pharma Kg Amides d'acide carboxylique, leur production et leur utilisation comme medicaments
DE10033337A1 (de) * 2000-07-08 2002-01-17 Boehringer Ingelheim Pharma Biphenylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9925174B2 (en) 2002-03-07 2018-03-27 Boehringer Ingelheim International Gmbh Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonyl-amino-imino-methyl)-phenylamino]-methyl}-1-methyl-1 H-benzimidazol acid ethyl ester and the salts thereof

Also Published As

Publication number Publication date
JP2004522759A (ja) 2004-07-29
WO2002062778A3 (fr) 2003-12-11
WO2002062778A2 (fr) 2002-08-15
EP1390357A2 (fr) 2004-02-25
MXPA03006648A (es) 2003-10-15

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