[go: up one dir, main page]

CA2431927A1 - Nouveaux polymeres a base de lieurs sans trace n-carbamyl-n'-dimethylsilyl methyl-piperazine pour la synthese en phase solide de bibliotheques a base phenyle - Google Patents

Nouveaux polymeres a base de lieurs sans trace n-carbamyl-n'-dimethylsilyl methyl-piperazine pour la synthese en phase solide de bibliotheques a base phenyle Download PDF

Info

Publication number
CA2431927A1
CA2431927A1 CA002431927A CA2431927A CA2431927A1 CA 2431927 A1 CA2431927 A1 CA 2431927A1 CA 002431927 A CA002431927 A CA 002431927A CA 2431927 A CA2431927 A CA 2431927A CA 2431927 A1 CA2431927 A1 CA 2431927A1
Authority
CA
Canada
Prior art keywords
denotes
compounds
alkyl
resin
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002431927A
Other languages
English (en)
Inventor
Enzo Cereda
Carlo Maria Pellegrini
Monica Quai
Walter Barbaglia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2431927A1 publication Critical patent/CA2431927A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/42—Introducing metal atoms or metal-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33303—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group
    • C08G65/3331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group cyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/336—Polymers modified by chemical after-treatment with organic compounds containing silicon
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

La présente invention porte sur des polymères qui se caractérisent par de nouveaux lieurs de silicium à base de la fraction carbamyle pipérazine, sur des procédés de préparation de ces polymères et sur leur utilisation dans la synthèse en phase solide de composés ou bibliothèques de composés renfermant un noyau phényle dans leur structure.
CA002431927A 2001-01-29 2002-01-15 Nouveaux polymeres a base de lieurs sans trace n-carbamyl-n'-dimethylsilyl methyl-piperazine pour la synthese en phase solide de bibliotheques a base phenyle Abandoned CA2431927A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01101946 2001-01-29
EP01101946.0 2001-01-29
PCT/EP2002/000312 WO2002060960A2 (fr) 2001-01-29 2002-01-15 Nouveaux polymeres a base de lieurs sans trace n-carbamyl-n'-dimethylsilyl methyl-piperazine pour la synthese en phase solide de bibliotheques a base phenyle

Publications (1)

Publication Number Publication Date
CA2431927A1 true CA2431927A1 (fr) 2002-08-08

Family

ID=8176316

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002431927A Abandoned CA2431927A1 (fr) 2001-01-29 2002-01-15 Nouveaux polymeres a base de lieurs sans trace n-carbamyl-n'-dimethylsilyl methyl-piperazine pour la synthese en phase solide de bibliotheques a base phenyle

Country Status (5)

Country Link
EP (1) EP1360211A2 (fr)
JP (1) JP2004518015A (fr)
CA (1) CA2431927A1 (fr)
MX (1) MXPA03006718A (fr)
WO (1) WO2002060960A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102122470B1 (ko) 2016-12-08 2020-06-12 주식회사 엘지화학 변성제 및 이로부터 유래된 작용기를 포함하는 변성 공액디엔계 중합체

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997044367A1 (fr) * 1996-05-20 1997-11-27 Smithkline Beecham Corporation Lieur a base de silyle pour la synthese organique en phase solide de molecules contenant de l'aryle
WO1999017869A2 (fr) * 1997-10-03 1999-04-15 Argonaut Technologies Compositions de synthese organique en phase solide et leurs methodes d'utilisation

Also Published As

Publication number Publication date
WO2002060960A2 (fr) 2002-08-08
EP1360211A2 (fr) 2003-11-12
WO2002060960A3 (fr) 2002-10-17
JP2004518015A (ja) 2004-06-17
MXPA03006718A (es) 2004-05-31

Similar Documents

Publication Publication Date Title
Valverde et al. Click à la carte: robust semi-orthogonal alkyne protecting groups for multiple successive azide/alkyne cycloadditions
EP0734398B1 (fr) Composes et procedes
Pavia et al. The design and synthesis of substituted biphenyl libraries
US6740712B2 (en) Polymers based on N-carbamyl-N'-dimethylsilyl methyl-piperazine traceless linkers for the solid phase synthesis of phenyl based libraries
CA2431927A1 (fr) Nouveaux polymeres a base de lieurs sans trace n-carbamyl-n'-dimethylsilyl methyl-piperazine pour la synthese en phase solide de bibliotheques a base phenyle
Giacalone et al. Polystyrene-supported organocatalysts for α-selenenylation and Michael reactions: A common post-modification approach for catalytic differentiation
US20040127719A1 (en) Alpha-isocyanocarboxylate solid support templates, method of preparation and for using the same
US6723798B1 (en) Resins having vinyl ether linker for the solid phase organic synthesis
CN110449183A (zh) 离子型铁（iii）配合物在制备烯丙基胺类化合物中的应用
EP0900241B1 (fr) Lieur a base de silyle pour la synthese organique en phase solide de molecules contenant de l'aryle
WO1997048671A1 (fr) Procede chimique
US5773512A (en) Compounds and methods
Kotha et al. Synthesis of spiro-cyclics via ring-closing metathesis
Dublanchet et al. Xanthates and solid-phase chemistry. A new soluble polymer analogue of Wang resin
JPH0448797B2 (fr)
Mincheva et al. Ionic liquid supports stable under conditions of peptide couplings, deprotections and traceless Suzuki reactions
AU1907401A (en) New functionalized polymeric reagents
WO1998017695A1 (fr) Composes et procedes
JP2002053768A (ja) 有機基を有するカーボンブラック、その製法及び使用
CN103382162A (zh) 一种酰基叠氮化合物的制备方法
EP0934345A1 (fr) Composes et procedes
IE922433A1 (en) Process for preparing 13&-cinnamoyl-baccatine iii or - 10-¹deacetylbaccatine iii
AU1642799A (en) Linkers
CA2279208A1 (fr) Nouvelles techniques de synthese en phase solide permettant de preparer divers composes analogues
Zakerinasab et al. Sulfamic acid supported on cellulose as a biodegradable and recyclable heterogeneous catalyst for the synthesis of tetrahydrobenzo xanthene derivatives

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued