CA2430469A1 - Thrombectomy device with multi-layered rotational wire - Google Patents

Abstract

An improvement to a thrombectomy apparatus for breaking up thrombus or other obstructive material in a lumen of a vascular graft or vessel having a wire and flexible sheath relatively movable, wherein the wire is sinuous in configuration and assumes its sinuous configuration when in the deployed configuration and has a straighter configuration in the first configuration. The wire is operatively connected to a motor for rotation of the wire to enable peaks of the sinuous wire to contact a wall of the lumen to break up the thrombus or other obstructive material. The improvement to the thrombectomy apparatus comprises the wire being formed of an inner core formed by a plurality of twisted wires and an outer wire wound directly around the inner core, wherein a distal portion of the outer wire extends distal of the inner core and progressively tapers towards a distal end to form a tapered region.

Description

THROMBECTOMY DEIitCE WITH MULTI-LAYERED ROTATIONAL 'WIRE
This application is a division of Canadian patent application SIN

2,424,354 filed on April 3, 2003.
BACKGROUND
Technical Field This application relates to a vascular device and more particularly to a thrombectomy device with an improved intravenous rotatable wine for clearing thrombus from dialysis grafts.
Background of Related Art Hemodialysis is a well-known method of simulating renal (kidney) function by circulating blood. The kidneys are organs which function to extract water and urea, mineral salts, toxins, and other waste products 'from the blood with filtering units called nephrons. From the nephrons the collected waste is sent to the bladder for excretion. For patients suffering from chronic renal insufficiency, hemodialysis is life saving because it provides a machine to simulate the function of the kidneys, thereby enabling the patients to live independently between dialysis treatments.
In the hemodialysis procedure, blood is withdrawn from the patient's body and transported to a dialysis machine, also commonly referred to as a kidney machine. In the dialysis machine, toxins and other waste products diffuse through a semi-permeable membrane into a dialysis fluid closely matching the chemical composition of the blood. The filtered blood, i.e. with the waste products removed, is then returned to the patient's body.
In one approach, an arteriovenous fistula is created so a high rate of blood flows from the artery into the patient's vein. The blood is then withdrawn directly from the patient's vein (native vein fistula) providing high rates of blood flow. Since this approach requires multiple needle sticks in the vein to withdraw and return the blood, the vein can eventually be damaged beyond usability, blood clots can form and the vein can fail. Once the vein fails, it could no longer be used for access and an alternate site must be utilized.
To avoid the repetitive damage to the vein, dialysis grafts are used.

~ 02430469 2003-05-29 _°z_ These grafts, typically made of PTFE, are implanted under the patient's skin, typically in the patient's forearm, and the graft is sutured at one end to the vein (venous anastomosis) for outflow and at the other end to the artery (arterial anastomosis) for inflow. The graft is also typically a loop graft to provide greater access area. This graft, which functions as a shunt creating high blood flow from the artery to the vein, enables access to thE: patient's blood without having to directly puncture the vein. That is, the tE:chnician sticks the two needles into the graft to respectively withdraw and return blood to the patient, with the inlet on the arterial side for blood requiring filtration processing and the outlet on the vein side for return of processed blood from the dialysis machine.
The dialysis graft, while providing an advantageous arrangement for hemodialysis, may become inoperable after a period of time due to thrombus or clots formed as a result of the high rate of blood flow through the graft and repetitive injury at the venous anastomosis.
There have been various attempts to break up of clots and other obstructing material in the graft. One approach is through injection of thrombolytic agents such as urokinase or streptokinase. These agents, however, are expensive, require lengthier hospital procedures and run the risks of drug toxicity and bleeding complications as the clots are broken.
Other approaches to breaking up obstructions involve mechanical thrombectomy devices. U.S. Patent No. 5,766,191 discloses a cage or basket composed of six memory wires that expand to press against the inner lumen to conform to the size and shape of the lumen. This multiple wire device is expensive and can be traumatic to the graft, possibly causing damage, since as the basket rotates at high speeds, the graft is contacted multiple times by the spinning wires. Other risks associated with the basket include the possibility of catching onto the graft itself and tearinc; the graft as well as catching and tearing the suture at the anastomotic site.
,Additionally, the basket can become filled with the clot which would then require time consuming withdrawal of the basket, cleaning the basket and reinserting it into the lumen.

_ 3 _ U.S. Patent No. 6,090,118 discloses a wire rotated to create a standing wave to remove thrombus. Pending IJ.S. patent application serial no.
10/113,248 filed April 1, 2002 discloses a rotating wire with a substantially sinuous configuration to create a wave-like rotational device. The single wire is less atraumatic than the aforedescribed basket device since it minimizes contact with the graft wall while still effectively mechanically removing thrombotic material.
The present application is directed to improvements to the thrombectomy device of the foregoing '118 patent and the '248 application.
These improvements include the attachment of the atraumatic tip to the distal tip of the rotatable wire and the construction of the rotational wire.
SUMMARY
The present invention provides improvements to the thrombectomy device disclosed in the foregoing "118 patent and '248 application having a rotating wire. IVlore specifically9 the improvement is to a thrombectomy apparatus for breaking up thrombus or other obstructive material in a lumen of a vascular graft or vessel having a flexible sheath and a wire po sitioned within the flexible sheath. The wire and flexible sheath of the thrombectomy apparatus are relatively movable so the wire has a first configuration and a second deployed configuration, and the wire is sinuous in configuration and assumes its sinuous configuration when in the deployed configuration and has a straighter configuration in the first configuration. The wire is operatively connected to a motor for rotation of the wire to enable peaks of the sinuous wire to contact a wall of the lumen to break up the thrombus or other obstructive material. The improvement to this thrombectomy apparatus comprises the wire being formed of an inner core formed by a plurality of twisted wires and an outer wire wound directly around the inner c:,ore, wherein a distal portion of the outer wire extends distal of the inner core and progressively tapers towards a distal end to form a tapered region.
The thrombectomy apparatus preferably further comprises a soft blunt tip affixed to the tapered region of the wire and extends distally beyond the ..._.._._....,_..,., ... . ._.....~.__ ._._........ ~ 02430469 2003-05-29 sa.
tapered region. The soft tip is preferably flexible andl made of any elastomeric material molded on the tapered region.
The tapered region of the outer wire preferably has individual coils spread apart from each other and has a hollow interior space therein, wherein the flexible polymeric tip flows to fill the spaces between the individual coils and the hollow interior space. In one embodiment, the individual coils of the wire in the tapered region are spread apart from each other by a~ distance approximately equal to a diameter of the wire of an individual coil.
In one embodiment, the soft tip is flexible and includes a proximate portion having a blind bore receiving the distal end of the wire and one or more swaged bands encircle the proximate portion of the flexiblE: tip to secure the tip on the distal end portion of the wire.
Preferably, the plurality of twisted wires of the inner core are wound in a first direction and the outer wire is tightly wound directly over the inner core in a direction opposite the first direction.
In one embodiment, the outer wire forms coils with esseni:ially no spaces between adjacent coils and the coils of the outer wire have an inner diameter approximately equal to an outer diameter of the inner core.
In one embodiment, the twisted wires of the inner core and the outer wire are composed of stainless steel, and at least some of the wires are heat treated at a temperature substantially less than 700 degrees Fahrenheit and substantially greater than 300 degrees Fahrenheit, and preferably about 500 degrees Fahrenheit, to retain the sinuous shape during rotation. The inner wires can be heat treated at a temperature and for a sufficient tune that the sinuous shape is retained for at least about 5 minutes when the 'wire is moved through a test fixture consisting of a return bent tube having an inner diameter approximating the inner diameter of a hemodialysis shunt and slightly greater than the maximum width of the wire in the area of the sinusoidal shape, without loss of physical integrity of the wire.

Preferred embodiments) of the present disclosure are described .. . .. . ~ 02430469 2003-05-29 herein with reference to the drawings wherein:
Figure 1 is a side view of the thrombectomy apparatus of the present invention having a sinuous rotational wire;
Figure 2 is a side view of the thrombectomy apparatus of Figure 1 with 5 one of the housing halves removed to illustrate the internal comlaonents of the device;
Figure 3A is an enlarged view of the detail A identified in Figure 2;
Figure 3B is an enlarged view of the detail B identified in Figure 2;
Figure 4 is a side view of the rotational wire of the apparatus of Figure 1;
Figure 5A is a side view of a section of the wire of Figure 4 with a portion cut away showing the inner core and outer wire wound around the inner core;
Figure 5B is an enlarged view of the distalmost tip of the rotational wire of Figure 4 (detail C) showing the tapered region;
Figure 5C is an enlarged side view, with parts broken away, of the distalmost tip of the wire with the atraumatic tip attached;
Figure 5~ is a distal end view of the wire with parts broken away;
Figure 5E is an enlarged side view, with parts. broken away, of an alternate embodiment with the atraumatic tip shown attached to the wire;
Figure 5F is an enlarged side view of the wire of Figure ~t, with parts broken away, shown without the atraumatic tip;
Figure 6 is an enlarged perspective view of the knob of the apparatus of Figure 1 for moving the flexible sheath to expose irhe rotational wire;
Figure 7 is a cross-sectional view of the knob of Figure 6;
Figure 3 is an enlarged view of the detail of Figure 7;
Figure 9 is a front view of the spacer of the a~>paratus of F=figure 1;
Figure 10 is a cross-sectional view of the spacer taken along lines 10-10 of Fig. 9;
Figure 11 is a front view of the seal of the apparatus of Figure 1;
Figure 12 is a cross-sectional view of the seal of Figure 11; and Figure 13 is an enlarged perspective view of the Touhy of the apparatus of Fig. 1;
Figure 14 is a diagrammatic side elevation of a wire in accordance with a process of manufacture.
DETAILED DESCRIPTI~N ~F PREFERRED EMB~DItVIENTS
Referring now in detail to the drawings where Pike reference numerals identify similar or like components throughout the several views, Figures 1 and 2 illustrate the thrombectomy apparatus of the present invention.
Apparatus 10 has a housing 12 composed of two housing halve:>, a flexible catheter (tube or sheath) 20 extending from a distal end 14 of hcrusing 12, and a rotational thrombectomy wire 30. i7ne of the housing halves is. removed in Figure 2 to illustrate the internal components of the apparatus 10.
Wire 30 is sinuous in configuration, having a substantially linear region extending through most if its length, from a proximal region through an intermediate region until distal region 36. At the distal region 36, wire 30 has a first arcuate region 34 facing a first direction (upwardly as vieHred in the orientation of Figure 1 ) and a second arcuate region 33 facing a second opposite direction (downwardly as viewed in the orientation of Figure 1 ).
Thus, as shown, the wire 30 assumes a shape resembling a sinE; curve.
The distal tip 37 of wire 30 is slightly curved as it cvntinuE;s the '°sine curve." Distal tip 37 progressively tapers toward the distalmost end 39 (see Fig 5B). The pitch of the tapered tip 37 is constant; riowever, it i:> greater than the rest of the wire 30 which is close-wound. 'This open-wind and narrowing diameter facilitate attachment of the atraumatic tip described below.
With continued reference to Figs. 5A-5D, and 5F, the wirE; 30, as shown, is composed of an inner core 31 formed of three twisted wire strands and an outer layer or coil 33 helicaliy wound directly around the braided inner core 31, after it is formed, and soldered to the inner core 31 at tree proximal and distal ends. The helically wound coil can cover the entire inner core 31, or alternately cover only the distal end. Also, as an alternative to the braided inner core 31, coil 33 can be wound around a solid core. This tic,~htly wound innerlouter core structure enables rotation of the distal end of they wire 30 corresponding to rotation at its proximal end as torque is transmiitted to the distal end. Rotation of the sinuous wire 30 results in a spiral path. The wires are preferably composed of stainless steel.
An atraumatic tip 40 (Figures 5G and 5E), preferably composed of rubber or 35D Pebax, a polyether block amide resin, although other eiastomeric materials are also contemplated, is insert molded or otherwise attached to the distalmost tip of the wire 30 to provide the appareatus 10 with an atraumatic distal tip to prevent damage to the graft or vessel wall during rotation of the wire 30. The tip 40 is slightly more flexible and soft than the distal portion of the wire 30. By varying the nature arid length of the polyether and polyamide blocks, desired hardness characteristics can be obtained, which can vary depending on the application. The end portion 44 of tip 40 can be tapered to a blunt or rounded end 41.
The polymer tip is flexible and is preferably molded in coretact with the tip by use of a heated die D, shown diagrammatically in Figures 5C and 5E.
Molten polymer flows between adjacent coils and sets for a relialble mechanical interconnection (interlock) of the polymer tip 40 and wire 30. In the preferred embodiment, the polymer fills the otherwise empty central cavity inside the coils. Preferably the most distal four to six coils of wire 30 are spread apart lengthwise sash that spaces approximately equal to the diameter of the coil wire are formed between the adjacent end coils to allow the molten polymer to flow to the interior of coils. That is, the distal end portion of the wire which has the section where the pitch of the coils is changed allows the polymer to interlock between the coils and securely anchor the tip 40 onto the 25 wire 30. This is achieved by stretching the most distal coils, thereby also decreasing the outer diameter of the wire in the area surrounded by the flexible tip 40, creating the aforedescribed taper. As shown, inner core 31 terminates proximally of the changed pitch region of the wire. As shown by way of example (see e.g. Figure 5B), the taper occurs at the last 4.5 coils, 30 extending a distance of about .080 inches in a wire h0aving a sinuous region of about 1.64 inches. Other dimensions are also contemplated.
As shown, the spread apart and pitched end coils preferably are of reduced outside diameter, as compared to the tightly wound endl coils positioned proximally therefrom. Thus the spread apart coifs will be covered by a greater thickness of the polymer material, reducing the likelihood that flexing of the tip 40 will result in penetration by the inclined coils or by the extreme distal end. The proximal portion 48 of the polymer tip 1 ~8 can be of a diameter slightly greater than the diameter of the tightly wound portion of the wire.
The extreme distal end 39 of the wire of the last coil is turned inward and flattened or blunted to decrease the possibility of the polymE:r tip being cut, penetrated, or broken in this area.
In the alternate embodiment of Figure 5E, the polymeric tip 80 is preformed with a blind bore or cavity 82 at its proximal portion 8'1, sized to receive the distal end portion 37' of the wire 30'. Once inserted over the wire, the preformed tip 80 could be secured by one or more swaged bands 84.
The flexible catheter (tube) 20 forms a slidable sheath to .compress the sinuous wire 30 during delivery. That is, when the sheath 20 is in the advanced position, the curved regions of the wire 30 are compressed so the wire 30 (including the distal region 36) is contained in the sheatf~' 20 in a substantially straight or linear configuration. This covering of thE: wire 30 facilitates insertion and manipulation through an introducer sheath. lNhen the flexible sheath (tube) 20 is retracted to the position of Figure 1 by proximal axial movement of knob 22, the distal region 36 of the wire 30 is exposed to enable the wire 30 to return to its pre-formed sinuous configuration shown in Figure 1. The wire 30 is preferably composed of stainless steel vvhich is pre-formed by a heat treating process to the curved configuration and returns to this position when released from the sheath 20.
Knob 22 (Figures 2 and 6-8) extends from distal end 14 of housing 12 and has a gripping region 26 and a shaft 28, with a lumen 27 extending therethrough. Flexible sheath 20 is attached within knob 22 sucll that sliding movement of knob 22 slides the flexible tube 20. Additionally, due to their attachment, knob 22 can be rotated to rotate the flexible sheath :z0 for positioning of the wire 30 when deployed. Strain relief 23 extends from knob _g_ 22 and receives sheath 20.
The proximal tabs 24 of the knob 22 (Figures 6 and 7) twiat into the threads (not shown) of the Touhy 70 to retain the sheath 20 in a retracted position to maintain the wire 30 in the exposed position. The tabs 24 also snap into a groove in the housing 12, adjacent the distal end 14, to retain the sheath in the distal position to maintain the wire in the non-deployed covered position. Although the flexible sheath 20 is shown as slidable with the wire fixed axially, alternatively, the wire can be axially slidable with the sheath stationary, or both the wire and sheath can be slidable. In any case, relative movement of the wire 30 and sheath 20 will enable the wire 30 to be exposed to assume the configuration described below to enak~le removal of obstructions from the vascular conduit, i.e. the vascular graft or the vessel wall. Lumen 27 of knob 22 tapers in a distal direction into grip p~artion 26 and then at transition region 29, progressively increases in diameter from transition region 29 towards the distal end.
With reference to Figs 2, 3A and 3B, the internal components of apparatus 10 will now be described. Containdd within housing 12 are a motor 60 and a battery 62 (two batteries are shown although one battery can also be used) which is contained within battery cassette 63. ll~embrane switch 6G1 is electrically connected by ribbon cable 68 to connector plug (male connector) E>5. Connector plug 65 is connected to connector pin (female connector) 66 which is connected to the negative terminal of motor 60 via wire 63. Wire 67 electrically connects female connector 66 to the negative terminal of battery 62s wire 6~3 connects the positive terminal of battery 62 to the positive terminal of motor 60.
Activation of switch 64 activates motor 60 to rotate wire 30 to perform the thrombectomy procedure. That is, motor 60 rotates wire 30 try rotating support tube 39. As can be appreciated with reference to Fig. 1, the structure includes motor gear 83, drive belt 87, and chuck or gear shaft 85 positioned over speed reducing gear 81which reduces the rotational speed (rpms) of the wire 30. Support tube 39 is bent inside gear shaft 85 by insertioin of a crimping tool through slot 86 in chuck 85 to bend it into a l1-sha~'e.
Wire 30 is operatively connected to motor 60 via support tube 39 which ~ 02430469 2003-05-29 1 () -is preferably composed of metal. Touhy 70 having extension arrn 72 is positioned within housing 12 and has a lumen communicating with the lumen of flexible sheath 20. Fluids, such a imaging dye can be injected through arm 72, flowing through flexible sheath 20, between wire 30 and the inner wall of the sheath 20, and exiting distal opening to flow into the graft or vessel.
This imaging dye provides an indication of flow through the graft. Touhy 70 contains a conventional silicone gasket or washer 7~i (see also F=igs. 11 and 12) which is compressed when tightened to provide a seal to prevent back flow of fluid around the support tube 39. An additional sealing structure is provided in the form of a disk shaped spacer 73 (see Figs. 9 and 10). The silicone gasket compresses the disk spacer 73 against the Touhy 70. The disk spacer 73 is on top of the silicone gasket 76 and compressEa the silicone gasket 76 into the Touhy 70. Threaded cap 75 of Touhy 70 (Figure 13) clamps down on the Touhy 70 to compress the washer 73 and spacer 76.
Turning now to one method of manufacture of the wire wherein the core is inserted into the bore of the wound outer coil, in prior methods of forming the wire into a wave shape, the three-strand core was looped as illustrated in Figure 14 and then heat treated at 700 degrees Fahrenheit for minutes for a stress relief cycle. /after heat treatment, the core was pulled through a hypotube (internal diameter of about .041-.043 inches) to relax the shape into the sinuous form. Heat treating prior to pulling the score was required for wave shape formation.
To improve the strength of the wire and reduce the tendency of the wire to unwind during rotation, a second heat treatment at 700 degrees for 15 minutes was conducted, but it decreased the time to failure. It was discovered that if the core wire and outer coil were wound in opposite directions, particularly with the core being wound in the directions opposite the intended rotational direction, and if the formed wave wire was heat treated once at 500 degrees F for 15 minutes, an unexpected performarece was obtained as compared to the original proposed wire, regardless of whether or not the wave shape was formed by pulling a looped wire through a hypotube or otherwise. ~Illhen tested in zone 2 (the most extreme testing c;ondition), fatigue life was increased by 2 to 3.times, while integrity of the wave shape was maintained. In comparison, with no heat treatment, or heat treatment at temperatures as high as 300 degrees F, the wave shape was lost prematurely.
Thus, in this embodiment of manufacture, the core strands are composed of stainless steel, such as 304 V hyten of a diameter of approximately .006 inch, and are twisted in a first direction opposite the direction of rotation of the driving member resulting in a core diGimeter of approximately .017 to .018 inch. After formation, the sinuous configuration is formed with two coplanar half loops extending outward about 1.;~ to 2.0 mm from the center line. It is heat treated at a temperature substantially less than 700 degrees F and substantially greater than 300 degrees F, and preferably at about 500 degrees F. The core is fitted within the outer coil which is a single strand wound in the opposite direction and with essentially no spaces between adjacent coils. The inner diameter of the outer coil is approximately equal to the outer diameter of the inner coil and the material is preferably r stainless steel, such as 304V spring temper stainless steel, of a diameter of about .009 inch. The outer coil is secured in position over the core, preferably by welding at the proximaB and distal ends. The outer coil form:> the wave shape of the core.
While the above description contains many specifics, those specifics should not be construed as limitations on the scope of the disclosure, but merely as exemplifications of preferred embodiments thereof. 'those skilled in the art will envision many other possible variations that are within the scope and spirit of the disclosure as defined by the claims appended hereto.

Claims (15)

WHAT IS CLAIMED IS

1. In a thrombectomy apparatus for breaking up thrombus or other obstructive material in a lumen of a vascular graft or vessel, the apparatus having a flexible sheath and a wire positioned within the flexible sheath, the wire and flexible sheath being relatively movable so the wire has a first configuration and a second deployed configuration, the wire being sinuous in configuration and assuming its sinuous configuration when in the deployed configuration and having a straighter configuration in the first configuration, the wire being operatively connected to a motor for rotation of the wire to enable peaks of the sinuous wire to contact a wall of the lumen to break up the thrombus or other obstructive material, the improvement comprising the wire formed of an inner core formed by a plurality of twisted wires and an outer wire wound directly around the inner core, a distal portion of the outer wire extending distal of the inner core and progressively tapering towards a distal end to form a tapered region.

2. The thrombectomy apparatus of claim 1, further comprising a soft blunt tip affixed to the tapered region of the outer wire.

3. The thrombectomy apparatus of claim 2, wherein the soft tip is composed of an elastomeric material molded on the distal end of the wire over the tapered region.

4. The thrombectomy apparatus of claim 1, wherein the tapered region of the outer wire has individual coils spread apart from each other and has a hollow interior space therein, and the apparatus further comprises a flexible tip filling the spaces between the individual coils and the hollow interior space, the flexible tip extending distally beyond the tapered region of the wire and having a blunt distal end.

5. The thrombectomy apparatus of claim 1, wherein the tapered region of the wire has spread apart individual coils forming spaces therebetween such that molding of a flexible polymeric tip in contact with the spread apart coils enables the polymer to flow between and to the interior of the coils, and the polymer is allowed to set to form the flexible tip on the tapered region of the wire.

6. The thrombectomy apparatus of claim 2 or 3, wherein the tapered region of the outer wire includes individual coils spread apart forming spaces therebetween and the soft blunt tip is flexible and fills the space, for a secure mechanical interlock of the tip on the tapered region of the wire.

7. The thrombectomy apparatus of claim 1, 2 or 3, wherein the outer wire has individual coils and the individual coils in the tapered regions are spread apart from each other by a distance approximately equal to a diameter of the wire of an individual coil.

8. The thrombectomy apparatus of claim 1, 2 or 3, wherein the tapered region of the outer wire includes individual coils spread apart forming spaces therebetween and the outer wire includes a tightly wound proximate section.

9. The thrombectomy apparatus of claim 2 or 3, wherein the soft tip is flexible and includes a proximate portion having a blind bore receiving the distal end of the wire and secured thereon.

10. The thrombectomy apparatus of claim 9, further comprising one or more swaged bands encircling the proximate portion of the tip to secure the tip on the distal end of the wire.

11. The thrombectomy apparatus of any one of claims 1 to 10, wherein the plurality of twisted wires of the inner core are wound in a first direction and the outer wire is tightly wound directly over the inner core in a direction opposite the first direction.

12. The thrombectomy apparatus of claim 1, 2 or 3, wherein the outer wire forms coils with essentially no spaces between adjacent coils and the coils of the outer wire have an inner diameter approximately equal to an outer diameter of the inner core.

13. The thrombectomy apparatus of any one of claims 1 to 12, wherein the twisted wires of the inner core and the outer wire are composed of stainless steel, and at least some of the wires are heat treated at a temperature substantially less than 700 degrees Fahrenheit and substantially greater than 300 degrees Fahrenheit to retain the sinuous shape during rotation.

14. The thrombectomy apparatus of claim 13, wherein the heat treated wires are heat treated at a temperature of about 500 degrees Fahrenheit.

15. The thrombectomy apparatus of any one of claims 1 to 14, wherein the inner wires are heat treated at a temperature and for a sufficient time that the sinuous shape is retained for at least about 5 minutes when the wire is moved through a test fixture consisting of a return bent tube having an inner diameter approximating the inner diameter of a hemodialysis shunt and slightly greater than the maximum width of the wire in the area of the sinusoidal shape, without toss of physical integrity of the wire.