CA2426047A1 - Oligonucleotides therapeutiques a toxicite reduite - Google Patents
Oligonucleotides therapeutiques a toxicite reduite Download PDFInfo
- Publication number
- CA2426047A1 CA2426047A1 CA002426047A CA2426047A CA2426047A1 CA 2426047 A1 CA2426047 A1 CA 2426047A1 CA 002426047 A CA002426047 A CA 002426047A CA 2426047 A CA2426047 A CA 2426047A CA 2426047 A1 CA2426047 A1 CA 2426047A1
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- oligonucleotide
- inx
- oligonucleotides
- therapeutic
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Il a été découvert que les oligonucléotides tendant à former des agrégats multimères présentent une plus grande toxicité sous la forme d'agrégats que sous une forme monomère. Ainsi, la présente invention présente des compositions oligonucléotidiques thérapeutiques à toxicité in vivo réduite et une méthode de production de ces compositions, ainsi qu'une méthode d'administration de l'oligonucléotide thérapeutique, dans laquelle l'oligonucléotide thérapeutique tend à former des agrégats multimères. Les compositions contenant ces oligonucléotides formant des agrégats sont traitées par chauffage, de préférence pas plus de 24 heures avant administration, ou utilisation d'espèces chimiques telles que le mannitol rompant les agrégats.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24517600P | 2000-11-02 | 2000-11-02 | |
| US60/245,176 | 2000-11-02 | ||
| PCT/CA2001/001540 WO2002036767A2 (fr) | 2000-11-02 | 2001-10-31 | Oligonucleotides therapeutiques a toxicite reduite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2426047A1 true CA2426047A1 (fr) | 2002-05-10 |
Family
ID=22925600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002426047A Abandoned CA2426047A1 (fr) | 2000-11-02 | 2001-10-31 | Oligonucleotides therapeutiques a toxicite reduite |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1330520A2 (fr) |
| JP (1) | JP2004512383A (fr) |
| AU (1) | AU2002214868A1 (fr) |
| CA (1) | CA2426047A1 (fr) |
| WO (1) | WO2002036767A2 (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4368176A4 (fr) * | 2021-07-08 | 2025-06-25 | Nippon Shinyaku Co., Ltd. | Agent de réduction de néphrotoxicité |
| EP4368186A4 (fr) * | 2021-07-08 | 2025-06-25 | Nippon Shinyaku Co., Ltd. | Agent de réduction de la néphrotoxicité |
| EP4368187A4 (fr) * | 2021-07-08 | 2025-07-02 | Nippon Shinyaku Co Ltd | Agent inhibiteur de précipitation |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| ATE335510T1 (de) | 1998-05-22 | 2006-09-15 | Ottawa Health Research Inst | Methoden und produkte zur induzierung mukosaler immunität |
| WO2004053104A2 (fr) | 2002-12-11 | 2004-06-24 | Coley Pharmaceutical Group, Inc. | Acides nucleiques 5'cpg et leurs methodes d'utilisation |
| NZ616745A (en) * | 2008-07-18 | 2014-06-27 | Oncogenex Tech Inc | Antisense formulation |
| JP2012507565A (ja) | 2008-10-30 | 2012-03-29 | グオ・ペイシュエン | Ｄｎａのシークエンシング及び他の用途のための、膜に組み込まれたウイルスｄｎａパッケージングモータタンパク質コネクタバイオセンサ |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5990299A (en) * | 1995-08-14 | 1999-11-23 | Icn Pharmaceuticals, Inc. | Control of CD44 gene expression for therapeutic use |
-
2001
- 2001-10-31 CA CA002426047A patent/CA2426047A1/fr not_active Abandoned
- 2001-10-31 AU AU2002214868A patent/AU2002214868A1/en not_active Abandoned
- 2001-10-31 JP JP2002539513A patent/JP2004512383A/ja active Pending
- 2001-10-31 EP EP01983356A patent/EP1330520A2/fr not_active Withdrawn
- 2001-10-31 WO PCT/CA2001/001540 patent/WO2002036767A2/fr not_active Ceased
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4368176A4 (fr) * | 2021-07-08 | 2025-06-25 | Nippon Shinyaku Co., Ltd. | Agent de réduction de néphrotoxicité |
| EP4368186A4 (fr) * | 2021-07-08 | 2025-06-25 | Nippon Shinyaku Co., Ltd. | Agent de réduction de la néphrotoxicité |
| EP4368187A4 (fr) * | 2021-07-08 | 2025-07-02 | Nippon Shinyaku Co Ltd | Agent inhibiteur de précipitation |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002214868A1 (en) | 2002-05-15 |
| JP2004512383A (ja) | 2004-04-22 |
| WO2002036767A2 (fr) | 2002-05-10 |
| WO2002036767A3 (fr) | 2003-01-23 |
| EP1330520A2 (fr) | 2003-07-30 |
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