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CA2417240A1 - Procede et composition d'immunisation utilisant des pools melanges d'acides nucleiques ou de peptides mutes - Google Patents

Procede et composition d'immunisation utilisant des pools melanges d'acides nucleiques ou de peptides mutes Download PDF

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Publication number
CA2417240A1
CA2417240A1 CA002417240A CA2417240A CA2417240A1 CA 2417240 A1 CA2417240 A1 CA 2417240A1 CA 002417240 A CA002417240 A CA 002417240A CA 2417240 A CA2417240 A CA 2417240A CA 2417240 A1 CA2417240 A1 CA 2417240A1
Authority
CA
Canada
Prior art keywords
target antigen
nucleic acid
vaccine
species
immune response
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002417240A
Other languages
English (en)
Inventor
Manuel Engelhorn
Alan N. Houghton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2417240A1 publication Critical patent/CA2417240A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne une réponse immunitaire à un antigène cible, qui est induite chez un sujet par l'administration d'une composition vaccinale dans des quantités suffisantes pour induire une réponse immunitaire à l'antigène cible. La composition vaccinale contient un pool mélangé de plusieurs espèces d'ADN ou d'ARN codant pour plusieurs formes mutantes de l'antigène cible, qui sont exprimées par le sujet, ou un mélange de peptides dérivé de l'expression avant administration du pool mélangé d'acides nucléiques. Les compositions vaccinales sont administrées à un sujet, par exemple un sujet humain, afin d'induire une réponse immunitaire à l'antigène cible.
CA002417240A 2000-08-07 2001-08-02 Procede et composition d'immunisation utilisant des pools melanges d'acides nucleiques ou de peptides mutes Abandoned CA2417240A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22316500P 2000-08-07 2000-08-07
US60/223,165 2000-08-07
PCT/US2001/024286 WO2002011748A1 (fr) 2000-08-07 2001-08-02 Procede et composition d'immunisation utilisant des pools melanges d'acides nucleiques ou de peptides mutes

Publications (1)

Publication Number Publication Date
CA2417240A1 true CA2417240A1 (fr) 2002-02-14

Family

ID=22835326

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002417240A Abandoned CA2417240A1 (fr) 2000-08-07 2001-08-02 Procede et composition d'immunisation utilisant des pools melanges d'acides nucleiques ou de peptides mutes

Country Status (4)

Country Link
EP (1) EP1311278A4 (fr)
AU (1) AU2001283094A1 (fr)
CA (1) CA2417240A1 (fr)
WO (1) WO2002011748A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1889963A (zh) * 2003-10-10 2007-01-03 宝德杰克特疫苗有限公司 方法
US9884893B2 (en) 2012-05-21 2018-02-06 Distributed Bio, Inc. Epitope focusing by variable effective antigen surface concentration
AU2015323944B2 (en) * 2014-10-01 2018-11-29 Inovio Pharmaceuticals, Inc. Vaccines having an antigen and interleukin-21 as an adjuvant
JP2025537232A (ja) * 2022-11-09 2025-11-14 センティヴァックス， インコーポレイテッド 低用量ワクチン組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4434585A (en) * 1985-03-30 1986-10-23 Marc Ballivet Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique
FR2677363A1 (fr) * 1991-06-07 1992-12-11 Pasteur Institut Compositions a base de peptides multiepitopiques, leur procede d'obtention et leurs applications, notamment en tant que vaccins.
US5741492A (en) * 1996-01-23 1998-04-21 St. Jude Children's Research Hospital Preparation and use of viral vectors for mixed envelope protein vaccines against human immunodeficiency viruses
DE19907485B4 (de) * 1999-02-12 2008-01-17 Strathmann Ag & Co. Virus-Vakzine

Also Published As

Publication number Publication date
AU2001283094A1 (en) 2002-02-18
EP1311278A4 (fr) 2005-01-05
EP1311278A1 (fr) 2003-05-21
WO2002011748A1 (fr) 2002-02-14

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Legal Events

Date Code Title Description
FZDE Discontinued