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CA2416698A1 - Films d'hydrogel et procedes de fabrication et d'utilisation de ces films - Google Patents

Films d'hydrogel et procedes de fabrication et d'utilisation de ces films Download PDF

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Publication number
CA2416698A1
CA2416698A1 CA002416698A CA2416698A CA2416698A1 CA 2416698 A1 CA2416698 A1 CA 2416698A1 CA 002416698 A CA002416698 A CA 002416698A CA 2416698 A CA2416698 A CA 2416698A CA 2416698 A1 CA2416698 A1 CA 2416698A1
Authority
CA
Canada
Prior art keywords
film
hydrogel
wound
films
polysaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002416698A
Other languages
English (en)
Inventor
Kelly R. Kirker
Glenn D. Prestwich
Yi Luo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2416698A1 publication Critical patent/CA2416698A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/336—Polymers modified by chemical after-treatment with organic compounds containing silicon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
    • C08B15/005—Crosslinking of cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C08G65/005—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds containing halogens
    • C08G65/007—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds containing halogens containing fluorine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Cette invention se rapporte à des films d'hydrogel améliorés utiles dans des traitements thérapeutiques. Cette invention concerne également des matières et des procédés servant à modifier et à polymériser des polysaccharides en films d'hydrogel qui gonflent après exposition à une solution aqueuse neutre. Ces procédés peuvent consister à modifier un polysaccharide ayant au moins un groupe acide carboxylique en un dérivé dihydrazide de polysaccharide, lequel est ensuite réticulé avec un polyaldéhyde pour créer un film d'hydrogel. Cette invention concerne également des compositions pharmaceutiques constituées par un composé pharmaceutiquement acceptable et par un film d'hydrogel décrit ci-dessus. Cette invention concerne en outre l'utilisation de ces films d'hydrogels et de ces compositions pharmaceutiques.
CA002416698A 2000-07-17 2001-07-17 Films d'hydrogel et procedes de fabrication et d'utilisation de ces films Abandoned CA2416698A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21872500P 2000-07-17 2000-07-17
US60/218,725 2000-07-17
PCT/US2001/022556 WO2002006373A1 (fr) 2000-07-17 2001-07-17 Films d'hydrogel et procedes de fabrication et d'utilisation de ces films

Publications (1)

Publication Number Publication Date
CA2416698A1 true CA2416698A1 (fr) 2002-01-24

Family

ID=22816250

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002416698A Abandoned CA2416698A1 (fr) 2000-07-17 2001-07-17 Films d'hydrogel et procedes de fabrication et d'utilisation de ces films

Country Status (4)

Country Link
EP (1) EP1305355A1 (fr)
AU (1) AU2001278943A1 (fr)
CA (1) CA2416698A1 (fr)
WO (1) WO2002006373A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04006875A (es) * 2002-01-18 2004-12-06 Control Delivery Sys Inc Sistema de gel polimerico para suministro controlado de cofarmacos.
US20050176620A1 (en) 2002-06-21 2005-08-11 Prestwich Glenn D. Crosslinked compounds and methods of making and using thereof
WO2004050712A1 (fr) * 2002-11-29 2004-06-17 Chugai Seiyaku Kabushiki Kaisha Support a liberation prolongee de medicaments
WO2005000402A2 (fr) 2003-05-15 2005-01-06 University Of Utah Research Foundation Composites anti-adherence et methodes d'utilisation desdits composites
AU2004297231B2 (en) 2003-12-04 2012-02-02 University Of Utah Research Foundation Modified macromolecules and associated methods of synthesis and use
US8293890B2 (en) 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
WO2006020231A2 (fr) 2004-07-21 2006-02-23 Medtronic, Inc. Appareils medicaux et methodes de reduction de fibroses localisees
WO2006085329A2 (fr) * 2005-02-14 2006-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Hydrogel adhesif depolymerise a base de polysaccharide, et son procede d'utilisation
ATE494308T1 (de) * 2005-11-22 2011-01-15 Centre Nat Rech Scient Neue derivate von hyaluronsäure, herstellungsverfahren dafür und verwendungen davon
US20080069857A1 (en) * 2006-04-12 2008-03-20 Yoon Yeo Compositions And Methods For Inhibiting Adhesions
EP1897543A1 (fr) 2006-08-30 2008-03-12 Euro-Celtique S.A. Gaufre de buprénorphine pour la thérapie de substitution
DE102008005172A1 (de) * 2008-01-19 2009-07-23 Mike Ehrlich Pharmazeutische Zusammensetzung zur Verhinderung von post-operativen Adhäsionen
KR101809863B1 (ko) 2008-01-30 2017-12-15 아스테리아스 바이오세라퓨틱스, 인크. 줄기 세포 유래 심근세포 배양용 합성 표면
US8329469B2 (en) 2008-01-30 2012-12-11 Geron Corporation Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
DK2247716T3 (da) 2008-01-30 2012-05-29 Geron Corp Syntetiske overflader til dyrkning af celler i kemisk defineret medie
CN105331577A (zh) 2008-01-30 2016-02-17 阿斯特利亚斯生物治疗股份公司 用于培养干细胞衍生的少突胶质细胞前体细胞的合成表面
WO2009134344A1 (fr) 2008-04-28 2009-11-05 Surmodics, Inc. Matrices à base de poly-α(1→4)glucopyranose réticulées avec un hydrazide
US8932622B2 (en) 2008-06-03 2015-01-13 Actamax Surgical Materials, Llc Tissue coating for preventing undesired tissue-to-tissue adhesions
WO2010132857A1 (fr) * 2009-05-14 2010-11-18 Central Michigan University Composition et procédé de préparation d'échafaudages de peau artificielle biodégradable à base de gel polysaccharidique
WO2010138074A1 (fr) * 2009-05-29 2010-12-02 Hilborn Joens Systèmes d'administration à base d'acide hyaluronique
FR2972113A1 (fr) * 2011-03-02 2012-09-07 Philippe Zanchetta Utilisation d'un melange de polysaccharides specifiques comprenant de l'acide hyaluronique, de la chondroitine 6 sulfate, du dermatane sulfate et de l'heparine en cicatrisation cutanee
WO2013010045A1 (fr) 2011-07-12 2013-01-17 Biotime Inc. Nouveaux procédés et formulations pour thérapie cellulaire orthopédique
PL3148517T3 (pl) * 2014-05-30 2021-11-29 The Research Foundation For The State University Of New York Kompozycje i sposoby do promowania tworzenia kości
CN113366025A (zh) * 2019-01-30 2021-09-07 鲍希与洛姆伯股份有限公司 交联的聚合物网络及其用途
CN110894302A (zh) * 2019-11-19 2020-03-20 福建医科大学孟超肝胆医院(福州市传染病医院) 一种基于亚胺键和酰腙键的抗菌水凝胶及其制备方法
CN113024845A (zh) * 2021-03-17 2021-06-25 广西医科大学 一种醛肼交联型抗菌水凝胶敷料的制备方法
CN114044548B (zh) * 2021-09-24 2023-08-11 杭州食疗晶元生物科技有限公司 一种快速降解水凝胶回收水资源的方法
CN114404648A (zh) * 2022-01-18 2022-04-29 张培华 促进糖尿病创面修复可降解抗菌止血水凝胶的制备方法
CN114486838B (zh) * 2022-02-18 2024-03-15 吉林大学 一种四环素类抗生素的检测方法
CN115252542A (zh) * 2022-07-29 2022-11-01 广州韵泽尚美生物科技有限公司 一种双疗程复合细胞生长因子水凝胶及其制备方法
CN119971127B (zh) * 2025-02-20 2025-10-28 金华市景迪医疗用品有限公司 一种创面修复用透明质酸钠凝胶复合物及其制备工艺

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Also Published As

Publication number Publication date
EP1305355A1 (fr) 2003-05-02
AU2001278943A1 (en) 2002-01-30
WO2002006373A1 (fr) 2002-01-24

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Legal Events

Date Code Title Description
FZDE Discontinued