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CA2416186A1 - Inhibition de l'expression genique au moyen d'analogues de polynucleotides - Google Patents

Inhibition de l'expression genique au moyen d'analogues de polynucleotides Download PDF

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Publication number
CA2416186A1
CA2416186A1 CA002416186A CA2416186A CA2416186A1 CA 2416186 A1 CA2416186 A1 CA 2416186A1 CA 002416186 A CA002416186 A CA 002416186A CA 2416186 A CA2416186 A CA 2416186A CA 2416186 A1 CA2416186 A1 CA 2416186A1
Authority
CA
Canada
Prior art keywords
embryo
analogue
teleost
egg
polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002416186A
Other languages
English (en)
Inventor
Stephen C. Ekker
Aidas Nasevicius
Hyon Kim
Saulius Sumanas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Minnesota System
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2416186A1 publication Critical patent/CA2416186A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/40—Fish
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des analogues de polynucléotides à spécificité de séquence et des procédés permettant de déterminer la fonction d'un acide nucléique comprenant une séquence connue.
CA002416186A 2000-07-31 2001-07-30 Inhibition de l'expression genique au moyen d'analogues de polynucleotides Abandoned CA2416186A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22172200P 2000-07-31 2000-07-31
US60/221,722 2000-07-31
US25286500P 2000-11-22 2000-11-22
US60/252,864 2000-11-22
US28497401P 2001-04-19 2001-04-19
US60/284,974 2001-04-19
PCT/US2001/041481 WO2002009509A2 (fr) 2000-07-31 2001-07-30 Inhibition de l'expression genique au moyen d'analogues de polynucleotides

Publications (1)

Publication Number Publication Date
CA2416186A1 true CA2416186A1 (fr) 2002-02-07

Family

ID=27396990

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002416186A Abandoned CA2416186A1 (fr) 2000-07-31 2001-07-30 Inhibition de l'expression genique au moyen d'analogues de polynucleotides

Country Status (4)

Country Link
EP (1) EP1335645A2 (fr)
AU (1) AU2001281371A1 (fr)
CA (1) CA2416186A1 (fr)
WO (1) WO2002009509A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003079776A2 (fr) * 2002-03-27 2003-10-02 Exelixis Deutschland Gmbh Identification du gene flt1 requis pour l'angiogenese dans le poisson zebre, et utilisations associees
ITRM20050169A1 (it) * 2005-04-07 2006-10-08 Lay Line Genomics Spa Uso di nothobranchius furzeri come sistema modello per la caratterizzazione di geni e farmaci che controllano l'invecchiamento.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506337A (en) * 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5726059A (en) * 1995-06-06 1998-03-10 Wisconsin Alumni Research Foundation Prosthetic RNA and use thereof to modify RNA expression

Also Published As

Publication number Publication date
WO2002009509A2 (fr) 2002-02-07
AU2001281371A1 (en) 2002-02-13
WO2002009509A3 (fr) 2003-05-15
EP1335645A2 (fr) 2003-08-20

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Legal Events

Date Code Title Description
FZDE Discontinued