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CA2413683A1 - Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire - Google Patents

Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire Download PDF

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Publication number
CA2413683A1
CA2413683A1 CA002413683A CA2413683A CA2413683A1 CA 2413683 A1 CA2413683 A1 CA 2413683A1 CA 002413683 A CA002413683 A CA 002413683A CA 2413683 A CA2413683 A CA 2413683A CA 2413683 A1 CA2413683 A1 CA 2413683A1
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Canada
Prior art keywords
alpha
substituted
methanoimidazo
alkyl
dione
Prior art date
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Abandoned
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CA002413683A
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English (en)
Inventor
Mark E. Salvati
James Aaron Balog
Weifang Shan
Soren Giese
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Bristol Myers Squibb Co
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Individual
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Publication of CA2413683A1 publication Critical patent/CA2413683A1/fr
Abandoned legal-status Critical Current

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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Abstract

L'invention concerne des composés cycliques condensés, des procédés d'utilisation de tels composés dans le traitement d'états associés au récepteur hormonal nucléaire, tels que le cancer et les troubles immuns, ainsi que des compositions pharmaceutiques contenant de tels composés.
CA002413683A 2000-06-28 2001-06-20 Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire Abandoned CA2413683A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US21439200P 2000-06-28 2000-06-28
US60/214,392 2000-06-28
US28461701P 2001-04-18 2001-04-18
US28443801P 2001-04-18 2001-04-18
US60/284,617 2001-04-18
US60/284,438 2001-04-18
PCT/US2001/019663 WO2002000653A2 (fr) 2000-06-28 2001-06-20 Modulateurs cycliques condenses de la fonction du recepteur hormonal nucleaire

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CA2413683A1 true CA2413683A1 (fr) 2002-01-03

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JP (1) JP2004515462A (fr)
AU (1) AU2002215609A1 (fr)
BR (1) BR0111869A (fr)
CA (1) CA2413683A1 (fr)
HU (1) HUP0303165A3 (fr)
MX (1) MXPA02012563A (fr)
NO (1) NO20026167D0 (fr)
NZ (1) NZ523802A (fr)
WO (1) WO2002000653A2 (fr)

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JP2000264876A (ja) * 1998-09-10 2000-09-26 Sumitomo Chem Co Ltd 縮合複素環化合物
IL152719A0 (en) 2000-06-28 2003-06-24 Bristol Myers Squibb Co Selective androgen receptor modulators and methods for their identification
US20030114420A1 (en) * 2000-06-28 2003-06-19 Salvati Mark E. Fused cyclic modulators of nuclear hormone receptor function
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
JP2004508373A (ja) * 2000-09-07 2004-03-18 バイエル・フアーマシユーチカルズ・コーポレーシヨン 環式および非環式アミジンおよびプロゲステロン受容体結合剤として使用するためのそれらを含有する医薬組成物
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
JP4434740B2 (ja) 2001-12-19 2010-03-17 ブリストル−マイヤーズ スクイブ カンパニー 核ホルモン受容体機能の調節剤である、縮合ヘテロ環化合物およびその類似体
DE10162375A1 (de) * 2001-12-19 2003-07-10 Bayer Ag Bicyclische N-Aryl-amide
WO2003080118A2 (fr) * 2002-03-18 2003-10-02 Pharmacia Corporation Combinaison d'un antagoniste de recepteur d'aldosterone et de derive d'acide fibrique
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
PL375042A1 (en) 2002-08-12 2005-11-14 Takeda Pharmaceutical Company Limited Fused benzene derivative and use
US7632858B2 (en) 2002-11-15 2009-12-15 Bristol-Myers Squibb Company Open chain prolyl urea-related modulators of androgen receptor function
US7199125B2 (en) 2003-10-02 2007-04-03 Bristol-Myers Squibb Company Spiro-cyclic compounds useful as anti-inflammatory agents
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7417040B2 (en) 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7625923B2 (en) * 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US8546451B2 (en) 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
CA2642205C (fr) * 2006-02-10 2015-01-27 Janssen Pharmaceutica N.V. Imidazole ou thiadiazole bicyclique servant de modulateur selectif de recepteur d'androgene
US20100004249A1 (en) 2006-07-11 2010-01-07 Takahiro Matsumoto Bicyclic heterocyclic compound and use thereof
EP2334683B1 (fr) 2008-08-29 2017-03-22 MSD Italia S.r.l. Dérivés hétérocycliques bicycliques saturés en tant qu antagonistes de smo
US9624161B2 (en) 2009-02-23 2017-04-18 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9427418B2 (en) 2009-02-23 2016-08-30 Gtx, Inc. Estrogen receptor ligands and methods of use thereof

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DE69531998T2 (de) * 1994-12-22 2004-07-22 Ligand Pharmaceuticals, Inc., San Diego Steroidrezeptor-modulator verbindungen und methoden
EP0918774B9 (fr) * 1996-06-27 2002-04-10 Ligand Pharmaceuticals Incorporated Composes modulateurs de recepteurs d'androgenes, leurs procedes de fabrication et d'utilisation
IL152719A0 (en) * 2000-06-28 2003-06-24 Bristol Myers Squibb Co Selective androgen receptor modulators and methods for their identification

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NZ523802A (en) 2005-11-25
WO2002000653A2 (fr) 2002-01-03
WO2002000653A3 (fr) 2002-07-25
HUP0303165A3 (en) 2006-05-29
NO20026167L (no) 2002-12-20
MXPA02012563A (es) 2003-05-14
JP2004515462A (ja) 2004-05-27
EP1299385A2 (fr) 2003-04-09
NO20026167D0 (no) 2002-12-20
BR0111869A (pt) 2003-09-23
HUP0303165A2 (hu) 2003-12-29
AU2002215609A1 (en) 2002-01-08

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