CA2409084A1 - Anti-inflammatory agent and foods and drinks containing the same - Google Patents
Anti-inflammatory agent and foods and drinks containing the same Download PDFInfo
- Publication number
- CA2409084A1 CA2409084A1 CA 2409084 CA2409084A CA2409084A1 CA 2409084 A1 CA2409084 A1 CA 2409084A1 CA 2409084 CA2409084 CA 2409084 CA 2409084 A CA2409084 A CA 2409084A CA 2409084 A1 CA2409084 A1 CA 2409084A1
- Authority
- CA
- Canada
- Prior art keywords
- fennel
- agent
- cacao
- food
- drink
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002260 anti-inflammatory agent Substances 0.000 title claims abstract description 73
- 229940121363 anti-inflammatory agent Drugs 0.000 title claims abstract description 73
- 235000013305 food Nutrition 0.000 title claims abstract description 49
- 239000000126 substance Substances 0.000 claims abstract description 43
- 239000000284 extract Substances 0.000 claims abstract description 38
- 235000004204 Foeniculum vulgare Nutrition 0.000 claims abstract description 36
- 235000004347 Perilla Nutrition 0.000 claims abstract description 36
- 244000299461 Theobroma cacao Species 0.000 claims abstract description 36
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 claims abstract description 35
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 claims abstract description 35
- 235000001046 cacaotero Nutrition 0.000 claims abstract description 35
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 30
- 241000198694 Passiflora pallida Species 0.000 claims abstract description 20
- 239000001387 apium graveolens Substances 0.000 claims abstract description 20
- 239000000177 juniperus communis l. berry Substances 0.000 claims abstract description 20
- 239000001917 trigonella foenum graecum l. absolute Substances 0.000 claims abstract description 20
- -1 Rosemary Substances 0.000 claims abstract description 19
- 230000003110 anti-inflammatory effect Effects 0.000 claims abstract description 17
- 239000004615 ingredient Substances 0.000 claims abstract description 15
- 230000001747 exhibiting effect Effects 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 238000000605 extraction Methods 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 241000212314 Foeniculum Species 0.000 claims 20
- 241000229722 Perilla <angiosperm> Species 0.000 claims 20
- 208000024891 symptom Diseases 0.000 abstract description 53
- 230000000694 effects Effects 0.000 abstract description 20
- 235000008216 herbs Nutrition 0.000 abstract description 20
- 230000002411 adverse Effects 0.000 abstract description 18
- 230000007774 longterm Effects 0.000 abstract description 18
- 244000124853 Perilla frutescens Species 0.000 abstract description 17
- 240000006927 Foeniculum vulgare Species 0.000 abstract description 16
- 208000026935 allergic disease Diseases 0.000 abstract description 14
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 11
- 206010039085 Rhinitis allergic Diseases 0.000 abstract description 9
- 201000010105 allergic rhinitis Diseases 0.000 abstract description 9
- 230000007815 allergy Effects 0.000 abstract description 8
- 206010067482 No adverse event Diseases 0.000 abstract description 5
- 230000000172 allergic effect Effects 0.000 description 20
- 208000010668 atopic eczema Diseases 0.000 description 20
- 241000218692 Cryptomeria Species 0.000 description 12
- 230000003266 anti-allergic effect Effects 0.000 description 12
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 238000002156 mixing Methods 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 241000544066 Stevia Species 0.000 description 5
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 5
- 235000012149 noodles Nutrition 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000001335 perilla frutescens leaf extract Substances 0.000 description 3
- 229940118431 perilla frutescens leaf extract Drugs 0.000 description 3
- 206010039083 rhinitis Diseases 0.000 description 3
- 235000014347 soups Nutrition 0.000 description 3
- 244000178231 Rosmarinus officinalis Species 0.000 description 2
- 208000032140 Sleepiness Diseases 0.000 description 2
- 206010041349 Somnolence Diseases 0.000 description 2
- 241000209140 Triticum Species 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- 238000011281 clinical therapy Methods 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000037321 sleepiness Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 235000021163 supper Nutrition 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 241000238876 Acari Species 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 244000036975 Ambrosia artemisiifolia Species 0.000 description 1
- 235000003129 Ambrosia artemisiifolia var elatior Nutrition 0.000 description 1
- 240000007154 Coffea arabica Species 0.000 description 1
- 241000218691 Cupressaceae Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 240000008620 Fagopyrum esculentum Species 0.000 description 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 235000004348 Perilla frutescens Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000003493 Rhinophyma Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 235000010716 Vigna mungo Nutrition 0.000 description 1
- 240000004922 Vigna radiata Species 0.000 description 1
- 235000010721 Vigna radiata var radiata Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 235000003484 annual ragweed Nutrition 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 235000006263 bur ragweed Nutrition 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 235000003488 common ragweed Nutrition 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 210000000750 endocrine system Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229940124595 oriental medicine Drugs 0.000 description 1
- 235000015927 pasta Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000009736 ragweed Nutrition 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
An anti-inflammatory agent exhibiting an anti-inflammatory function is provided, which includes either a set of dried substances or an extract of Perilla leaf, Cacao and Fennel, and preferably Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed. This specific set or combination of those natural herbs is effective to relax and suppress symptoms of allergy, particularly holistic symptoms of allergic rhinitis, without causing any substantive adverse effects. Since all of the ingredients included in agent are derived from the natural herbs, a long-term administration of the agent may cause substantively no adverse effects.
Also, inclusion of the agent into foods and drinks is also useful.
Also, inclusion of the agent into foods and drinks is also useful.
Description
Pf 30651second application /Herb-Road/CAlmh ANTI-INFLAMMATORY AGENT AND FOODS AND DRINKS
CONTAINING THE SAME
BACKGROUND OF THE INVENTION
1. Field of the Invention The present invention relates to an anti-inflammatory agent and fools and drinks containing the agent, and more particul"arly to an anti-inflammatory agent effectively inhibiting allergic diseases such as pollen disease and highly suppressing adverse reactions as compared to drugs particularly in case of long-term administration as well as to fools and drinks containing the agent.
CONTAINING THE SAME
BACKGROUND OF THE INVENTION
1. Field of the Invention The present invention relates to an anti-inflammatory agent and fools and drinks containing the agent, and more particul"arly to an anti-inflammatory agent effectively inhibiting allergic diseases such as pollen disease and highly suppressing adverse reactions as compared to drugs particularly in case of long-term administration as well as to fools and drinks containing the agent.
2. Description of the Related Art The pollen disease is one of various allergic diseases such as allergic rhinitis. In Japan, the pollen disease has frequently appeared but mostly in the last two decades. In recent years, the incidence rate of the pollen disease has been on the remarkable increase. At present, approximately 30% of the nation of Japan has displayed any allergic symptoms caused by the pollen disease.
In the past, a typical example of allergy-causing pollens was only Pagc 1 Pf 3065/second application /Herb-Road/CA./mh a pollen of cryptomeria. In contrast, recently there have often appeared various allergic symptoms due to not only the pollen of cryptomeria but also other pollens, for example, of cypress and ragweed. Such a variety of allergy-causing pollens results in an increased term for possible incidences of the pollen diseases. Further, other cases of allergic symptoms caused by house dusts or mites have been affirmed. In these cases, such allergic symptoms may often he continued throughout the year.
Research of the therapy for the pollen diseases has widely and aggressively been made, and some available measures of therapy have already been developed and used in clinical therapy. Notwithstanding, these therapy measures have not yet demonstrated the desired almost perfect and satisfactory effects and results of therapy due to those merits and demerits.
Incidence of the pollen diseases causes various unpleasant symptoms such as sneeze, rhinitis, rhinorrhea, rhinophyma, headache and heavy itch on eyes. Administration of therapeutic drug for reducing and suppressing such unpleasant symptoms may, unfortunately, however, cause undesired adverse effects such as sleepiness. Either the various unpleasant symptoms or the undesired adverse effects would be influential to the quality of life to no small extent.
In the meantime, artificially-prepared anti-allergic and steroid drugs have already been developed and used for clinical therapy. A long-term administration of those drugs may, however, cause various deteriorations of symptom such as rebound phenomenon and undesired adverse effects such as abnormal sleepiness due to those strong activation Pf 3065/second application /Herb-Road/CA/mh to central nervous system of human, and undesirable influences to endocrine system of human. In all cases, the administration of those drugs should be made according to the instructions of medical doctor.
In parallel to the research and developments of the artificially-prepared drugs, it was also attempted to find out any natural anti-allergic substances obtainable from natural foods because natural anti-allergic substances may be safe for human body and almost free from any substantive adverse effects. Developments of foods containing those natural anti-allergic substances are disclosed in three Japanese laid-open patent publications No. 61-291524, No. 1-121217, and No. 7-215884.
Typical examples of well known natural anti-allergic substances are Rubussuavissimus extract and Perilla frutescens leaf extract.
Rubussuavissimus extract is extracted by a hot water from leaf of Rubussuavissimus. Perilla frutescens leaf extract is extracted by a hot water from leaf of Perilla frutescens.
As results of the clinical researches for those extracts, it was confirmed that Rubussuavissimus extract is effective to relax allergic symptoms and suppress allergic incidences onto circulatory organs such as rhinitis, sneeze and soreness on throat, while Perilla frutescens leaf extract is effective to relax and suppress skin inflammation.
Further, those natural food materials would be extremely safe to human body upon a long-term intake and be almost free from any substantive adverse effects because those natural food materials have been taken in the past long-term. Those natural anti-allergic substances have Pf 3065/second application /Herb-Road/CA/mh been utilized as anti-allergy functional ingredient for the anti-allergic foods.
In conclusion, as described above, the artificially-prepared anti-allergic drugs may cause various adverse effects, and thus should be administrated in accordance with the medical doctor's instructions. Since the long-term administration of those drugs should be avoided, those drugs would thus be unsuitable for relaxation and suppression of the allergic symptoms for the long-term.
The above-described natural anti-allergic substances obtainable from the foods are superior in safety to the human body in case of the long-term intake and also are almost free of any substantive adverse effects.
Notwithstanding, these natural anti-allergic substances suppress only part of vital allergic reactions which will give rise to the ahergic disease.
Namely, the natural anti-allergic substances are effective for relaxation and suppression of part of the allergic symptoms, but not for holistic symptoms.
In the above circumstances, a novel anti-inflammatory agent and fools and drinks containing the agent free from the above problems are desirable.
SUMMARY OF THE INVENTION
Accordingly, it is an object of the present invention to provide a novel anti-inflammatory agent free from the above problems.
It is a further object of the present invenrion to provide a novel anti-inflammatory agent exhibiting superior anti-inflammatory effects.
Pf 3065/second application /Herb-Road/CA/mh It is a still further object of the present invention to provide a novel anti-inflammatory agent effective to relax and suppers symptoms of allergy, particularly holistic symptoms of allergic rhinitis.
It is yet a further object of the present invention to provide a novel anti-inflammatory agent free from any substantive adverse effects.
It is yet a further object of the present invention to provide a novel anti-inflammatory agent with high safety to human body in a long-term administration.
In addition, also it is an object of the present invention to provide foods and drinks containing a novel anti-inflammatory agent free from the above problems.
It is a further additional object of the present invention to provide foods and drinks containing a novel anti-inflammatory agent exhibiting superior anti-inflammatory effects.
It is a still further additional object of the present invention to provide foods and drinks containing a novel anti-inflammatory agent effective to relax and suppers symptoms of allergy, particularly holistic symptoms of allergic rhinitis.
It is yet a further additional object of the present invention to provide foods and drinks containing a novel anti-inflammatory agent free from any substantive adverse effects.
It is still more additional object of the present invention to provide foods and drinks containing a novel anti-inflammatory agent with high safety to human body in a long-term administration.
Page S
Pf-3065/second application /Herb-Road/CAlmh The present invention was made and the above objects were achieved based on a long-term experiment in the oriental medicine of the present inventor for thirty five years.
An anti-inflammatory agent exhibiting an anti-inflammatory function is provided, which includes either a set of dried substances or an extract of Perilla leaf, Cacao arid Fennel, and preferably Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed. This specific set or combination of those natural herbs is important and essential for the present invention to provide desired superior anti-inflammatory effects, for example, to relax and suppress symptoms of allergy, particularly holistic symptoms of allergic rhinitis, without causing any substantive adverse effects. Since all of the ingredients included in the anti-inflammatory agent are derived from the natural herbs which are highly safe to human body, a long-term administration of the anti-inflammatory agent may cause substantively no adverse effects. Also, foods and drinks containing the anti-inflammatory agent are also provided.
The above and other objects, features and advantages of the present invention will be apparent from the following descriptions.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
A primary aspect of the present invention is to provide an anti-inflammatory agent exhibiting an anti-inflammatory function, wherein the anti-inflammatory agent includes a set of dried substances of Perilla leaf, Pf 3065/second application /Herb-Road/CA/mh Cacao and Fennel, and preferably Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed. This specific set or combination of those natural herbs is important and essential for the present invention to provide desired superior anti-inflammatory effects, for example, to relax and suppress symptoms of allergy, particularly holistic symptoms of allergic rhinitis, without causing any substantive adverse effects. Since all of the ingredients included in the anti-inflammatory agent are derived from the natural herbs which are highly safe to human body, a long-term administration of the anti-inflammatory agent may cause substantively no adverse effects.
The anti-inflammatory agent may practically be prepared by blending or mixing those herbs in particular conditions that respective ranges of relative ratios in weight of the dried substances of Perilla leaf, Cacao and Fennel are 6~2 : 6~2 : 4~1. In the practical preparation for the agent, typically, those respective relative ratios in weight of the dried substances of Perilla leaf, Cacao and Fennel may be 3 : 3 : 2.
The anti-inflammatory agent may practically be prepared by blending or mixing those herbs in particular conditions that respective ranges of relative ratios in weight of the dried substances of Perilla leaf, Cacav, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed are 6--2 : 6~2 : 4-1 : 4~1 : 4~1 : 4~1 : 30.3. In the practical preparation for the agent, typically, those respective relative ratios in weight of the dried substances of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed may be 3 : 3 : 2 : 2 : 2 : 2 : 1.
Pf-3065/second application /Herb-Road/CA/mh In the practical preparation for the agent, the dried substances may preferably and conveniently be in the form of mixed dry powders.
Optionally, it may be possible to add a sweetness-providing natural herb, for example, Stevia to the above anti-inflammatory agent, wherein respective ranges of relative ratios in weight of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry, Celery seed and Stevia are 6.-2 : 6~2 : 4~I : 4~1 : 4--1 : 4~1 : 30.3 : 30.3.
In the practical administration of the agent, an appropriate dose depends on the state of disease, and patient's age and other factors. One typical example of the daily dose may be in the range of 15-25g.
Another primary aspect of the present invention is to provide an anti-inflammatory agent exhibiting an anti-inflammatory function, wherein the anti-inflammatory agent includes an extract extracted from Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed.
This specific set or combination of those natural herbs is important and essential for the present invention to provide desired superior anti-inflammatory effects, for example, to relax and suppress symptoms of allergy, particularly holistic symptoms of allergic rhinitis, without causing any substantive adverse effects. Since all of the ingredients included in the anti-inflammatory agent are derived from the natural herbs which are highly safe to human body, a long-term administration of the anti-inflammatory agent may cause substantively no adverse effects.
In the practical preparation, the above specific extract may be extracted by a hot water from a set of dried substances of Perilla leaf, Pf-3065/second application /Herb-Road/CA/mh Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed.
Those dried substances may be obtained by either directly drying those herbs in the original or crude shape, or in combination of subsequent grinding the dried herbs into dry powders. The practical extraction may, typically, be made by using a hot water of a temperature in the range of 90-100°C and for a time in the range of 30-SO minutes. A weight ratio of the hot water with reference to the set of dried substances of those herbs may be, but not limited to, in the range of 10-100 times, and preferably 15-25 in the extraction-operation and efficiency points of view.
The above extract included in the agent may be either in a dry-state and a liquid state. The dry-state extract may practically be obtained by drying the liquid state-extract extracted by the hot water. The available dry processes are, for example, spray-dry and freeze-dry to form a granular extract.
Similarly to the first primary aspect, it may optionally be possible to add Stevia as a natural herb sweetener to the agent.
In the practical administration of the agent, an appropriate dose depends on the state of disease, and patient's age and other factors. One typical example of the daily dose may be in the range of, but not limited to, 15-ZSg.
Still another aspect of the present invention is to provide food and drink including an effective ingredient which comprises the novel anti-inflammatory agent described above in connection with the first primary and second primary aspects of the present invention. One typical example Pf-3065/second application /Herb-Road/CA/mh of the practical amount of the effective ingredient included in food and drink may be in the range of, but not limited to, 1-20 percents by weight.
Applicable foods and drinks are any foods and drinks which may include, but not limited to, general foods and drinks, health foods and drinks, and nutritionally supplemental foods and drinks. Typical examples of the general foods and drinks may include various soups, various beverages such as juices, liquors, mineral waters, coffees and teas, various confectioneries such as gum, candy, chocolate, snack and jelly, and various noodles such as buckwheat noodle, Japanese wheat noodle, Chinese wheat noodle, and pasta. Intake of those foods and drinks in the daily diets is effective for prevention and relaxation of the allergic symptoms in the long-term without causing any substantive adverse effect. The very long-term intake of those foods and drinks in the daily diets may ameliorate allergic predisposition.
In Japanese laid-open patent publication No. 9-87189 which is hereby incorporated as reference, it is disclosed that extracts from Labiatae plant such as leaf, flower and root thereof have anti-allergic functions.
In contrast, the present inventor discovered that the above-described specific set or combination of the natural herbs is important and essential to provide desired superior anti-inflammatory effects, for example, to relax and suppress symptoms of allergy, particularly holistic symptoms of allergic rhinitis, without causing any substantive adverse effects. Since all of the ingredients included in the anti-inflammatory agent are derived from the natural herbs which are highly safe to human body, a long-term Pf 3065/second application /Herb-Road/CAJmh administration of the anti-inflammatory agent may cause substantively no adverse effects.
The following examples are typical examples for practicing the foregoing aspects of the present invention. Although the subject matters of the present invention have been described in details, the following additional descriptions in one or more typical preferred embodiments or examples will be made for making it easy to understand the typical modes for practicing the foregoing aspects of the present invention.
E~P1 ~F~~L~Raration of anti-inflammatory ag_en 1 In one preferred example of the present invention, an anti-inflammatory agent was prepared by blending dry powers of the dry herbs at specific weight ratios as follows.
3g of Perilla leaf, 3g of Cacao, 2g of Fennel, 2g of Fenugreek seed, 2g of Rosemary, Zg of Juniper berry, 1g of Celery seed and 0.7g of Stevia were mixed in dry-powered state to prepare the anti-inflammatory agent. This anti-inflammatory agent will be refereed to as the anti-inflammatory agent of example 1 of the present invention.
F.~X ,MpLE 2 : ~(~rypar~tion of an i-infl ma ory a entl In one preferred example of the present invention, an anti-inflammatory agent was prepared by blending dry powers of the dry herbs at specific weight ratios as follows.
3g of Perilla leaf, 3g of Cacao and 2g of Fennel were mixed in Pf-3065/second application /Herb-Road/CAlmh dry-powered state to prepare the anti-inflammatory agent. This anti-inflammatory agent will be refereed to as the anti-inflammatory agent of example 2 of the present invention.
COMPARATIVE EXAMPj,E 7 :~~renaration of anti-inflammatory agentl In one comparative-example of the prior art, an anti-inflammatory agent was prepared by blending dry powers of the dry herbs at specific weight ratios as follows.
3g of Perilla leaf and 2g of Rosemary were mixed in dry-powered state to prepare the anti-inflammatory agent. This anti-inflammatory agent will be refereed to as the anti-inflammatory agent of comparative example 1.
In another comparative-example of the prior art, an anti-inflammatory agent was prepared by blending dry powers of the dry herbs at specific weight ratios as follows.
3g of Cacao and 2g of Fennel were mixed in dry-powered state to prepare the anti-inflammatory agent. This anti-inflammatory agent will be refereed to as the anti-inflammatory agent of comparative example 2.
37-patients of cryptomeria pollen disease with sneeze and rhinitis symptoms seasonally appeared in February through May and/or other 1'agc 12 Pf-3065/second application /f~ierb-Road/CAJmh allergic diseases continuously appeared throughout the year were treated as follows.
A first group of 31 cases of the 42-patients administrated daily two times an extract which was extracted by a hot water of 10090 for 35 minutes from the anti-inflammatory agent of example 1 of the present invention.
A second group of 5 cases of the 42-patients administrated daily two times an extract which was extracted by a hot water of 10090 for 35 minutes from the anti-inflammatory agent of example 2 of the present invention.
A third group of other 3 cases administrated daily two times an extract which was extracted by a hot water of 100°0 for 35 minutes from the anti-inflammatory agent of comparative example 1.
A fourth group of the remaining 3 cases administrated daily two times an extract which was extracted by a hot water of 100°~C for 35 minutes from the anti-inflammatory agent of comparative example 2.
The above administrations were continued for four weeks and then the evaluations were made on the basis of the following criterions.
"A" : Remarkably effective : all of the symptoms were disappeared "B" : Effective : most of the symptoms were disappeared, but a few symptoms sill resided "C" : Somewhat effective : only a few symptoms were disappeared but most of the symptoms sill resided "D" : Not effective : none of any significant effect was confirmed.
Pf 30b5/second application /Herb-Road/CA/mh The results of the evaluations are shown on the following Table 1.
criterio ns "A " "B " " C" "D"
first gr oan 14 cases9 cases5 cases'~ cases second g~~ 2 cases1 case 0 case 0 case thiy ~~ 0 case 0 yase 1 case 2 cases g , r,~p 0 cad 0 case 0 case 3 cases fount From the first group, it was demonstrated that administration of the anti-inflammatory agent of example 1 of the present invention is, in most cases, significantly effective to relax and suppress the cryptomeria pollen symptoms and other permanent allergic symptoms. In addition, it was also confirmed that all of the 31 cases of the first group were free from any adverse effects. A certain amelioration in the cryptomeria pollen symptoms and other permanent allergic symptoms was initiated on third day from the start of the administration. One week after the start of administration, most of the 31 cases of the first group subjectively felt a certain reduction in cryptomeria pollen symptoms and other permanent allergic symptoms. 1'wo weeks after the start of administration, the above remarkable effectiveness to relax and suppress the cryptomeria pollen symptoms and other permanent allergic symptoms was confirmed.
Pf 3065/second application /Herb-Road/CAJmh In addition, from the second group, it was demonstrated that administration of the anti-inflammatory agent of example 1 of the present invention is, some cases, significantly effective to relax and suppress the cryptomeria pollen symptoms and other permanent allergic symptoms. It was also confirmed that all of the 5 cases of the first group were free from any adverse effects. A certain amelioration in the cryptomeria pollen symptoms and other permanent allergic symptoms was initiated on third day from the start of the administration. One week after the start of administration, a majority of the 5 cases of the second group subjectively felt a certain reduction in cryptomeria pollen symptoms and other permanent allergic symptoms. ~vo weeks after the start of administration, the above remarkable effectiveness to relax and suppress the cryptomeria pollen symptoms and other permanent allergic symptoms was confirmed.
In contrast, the third and fourth groups demonstrated that either administration of the anti-inflammatory agents of comparative examples 1 and 2 is not substantially effective to relax and suppress the cryptomeria pollen symptoms and other permanent allergic symptoms.
In conclusion, the above text demonstrated that the above-described specific set or combination of the natural herbs is important and essential to provide desired superior anti-inflammatory effects, for example, to relax and suppress symptoms of allergy, particularly holistic symptoms of allergic rhinitis, without causing any substantive adverse effects.
Pf 3065/second application /Herb-Road/CA~/mh In another preferred example of the present invention, a soup containing the above-described anti-inflammatory agent of example 1 of the present invention was prepared, wherein the ingredients of the soup were 20 wt-% of the anti-inflammatory agent, 30 wt-% of green gram, 1.5 wt-% of Stevia, 1 wt-% of salt and 47.5 wt-% of water.
From this example, it was demonstrated that inclusion of the anti-inflammatory agent into the foods and drinks, which may be taken by daily diets, is practically useful for habitual intake of the anti-inflammatory agent for a long-term, for example, throughout the year in order to previously prevent allergic disease and ameliorate allergic predisposition.
Although the invention has been described above in connection with several preferred embodiments therefor, it will be appreciated that those embodiments have been provided solely for illustrating the invention, and not in a limiting sense. Numerous modiftcations and substitutions of equivalent materials and techniques will be readily apparent to those skilled in the art after reading the present application, and all such modifications and substitutions are expressly understood to fall within the true scope and spirit of the appended claims.
Page 1b
In the past, a typical example of allergy-causing pollens was only Pagc 1 Pf 3065/second application /Herb-Road/CA./mh a pollen of cryptomeria. In contrast, recently there have often appeared various allergic symptoms due to not only the pollen of cryptomeria but also other pollens, for example, of cypress and ragweed. Such a variety of allergy-causing pollens results in an increased term for possible incidences of the pollen diseases. Further, other cases of allergic symptoms caused by house dusts or mites have been affirmed. In these cases, such allergic symptoms may often he continued throughout the year.
Research of the therapy for the pollen diseases has widely and aggressively been made, and some available measures of therapy have already been developed and used in clinical therapy. Notwithstanding, these therapy measures have not yet demonstrated the desired almost perfect and satisfactory effects and results of therapy due to those merits and demerits.
Incidence of the pollen diseases causes various unpleasant symptoms such as sneeze, rhinitis, rhinorrhea, rhinophyma, headache and heavy itch on eyes. Administration of therapeutic drug for reducing and suppressing such unpleasant symptoms may, unfortunately, however, cause undesired adverse effects such as sleepiness. Either the various unpleasant symptoms or the undesired adverse effects would be influential to the quality of life to no small extent.
In the meantime, artificially-prepared anti-allergic and steroid drugs have already been developed and used for clinical therapy. A long-term administration of those drugs may, however, cause various deteriorations of symptom such as rebound phenomenon and undesired adverse effects such as abnormal sleepiness due to those strong activation Pf 3065/second application /Herb-Road/CA/mh to central nervous system of human, and undesirable influences to endocrine system of human. In all cases, the administration of those drugs should be made according to the instructions of medical doctor.
In parallel to the research and developments of the artificially-prepared drugs, it was also attempted to find out any natural anti-allergic substances obtainable from natural foods because natural anti-allergic substances may be safe for human body and almost free from any substantive adverse effects. Developments of foods containing those natural anti-allergic substances are disclosed in three Japanese laid-open patent publications No. 61-291524, No. 1-121217, and No. 7-215884.
Typical examples of well known natural anti-allergic substances are Rubussuavissimus extract and Perilla frutescens leaf extract.
Rubussuavissimus extract is extracted by a hot water from leaf of Rubussuavissimus. Perilla frutescens leaf extract is extracted by a hot water from leaf of Perilla frutescens.
As results of the clinical researches for those extracts, it was confirmed that Rubussuavissimus extract is effective to relax allergic symptoms and suppress allergic incidences onto circulatory organs such as rhinitis, sneeze and soreness on throat, while Perilla frutescens leaf extract is effective to relax and suppress skin inflammation.
Further, those natural food materials would be extremely safe to human body upon a long-term intake and be almost free from any substantive adverse effects because those natural food materials have been taken in the past long-term. Those natural anti-allergic substances have Pf 3065/second application /Herb-Road/CA/mh been utilized as anti-allergy functional ingredient for the anti-allergic foods.
In conclusion, as described above, the artificially-prepared anti-allergic drugs may cause various adverse effects, and thus should be administrated in accordance with the medical doctor's instructions. Since the long-term administration of those drugs should be avoided, those drugs would thus be unsuitable for relaxation and suppression of the allergic symptoms for the long-term.
The above-described natural anti-allergic substances obtainable from the foods are superior in safety to the human body in case of the long-term intake and also are almost free of any substantive adverse effects.
Notwithstanding, these natural anti-allergic substances suppress only part of vital allergic reactions which will give rise to the ahergic disease.
Namely, the natural anti-allergic substances are effective for relaxation and suppression of part of the allergic symptoms, but not for holistic symptoms.
In the above circumstances, a novel anti-inflammatory agent and fools and drinks containing the agent free from the above problems are desirable.
SUMMARY OF THE INVENTION
Accordingly, it is an object of the present invention to provide a novel anti-inflammatory agent free from the above problems.
It is a further object of the present invenrion to provide a novel anti-inflammatory agent exhibiting superior anti-inflammatory effects.
Pf 3065/second application /Herb-Road/CA/mh It is a still further object of the present invention to provide a novel anti-inflammatory agent effective to relax and suppers symptoms of allergy, particularly holistic symptoms of allergic rhinitis.
It is yet a further object of the present invention to provide a novel anti-inflammatory agent free from any substantive adverse effects.
It is yet a further object of the present invention to provide a novel anti-inflammatory agent with high safety to human body in a long-term administration.
In addition, also it is an object of the present invention to provide foods and drinks containing a novel anti-inflammatory agent free from the above problems.
It is a further additional object of the present invention to provide foods and drinks containing a novel anti-inflammatory agent exhibiting superior anti-inflammatory effects.
It is a still further additional object of the present invention to provide foods and drinks containing a novel anti-inflammatory agent effective to relax and suppers symptoms of allergy, particularly holistic symptoms of allergic rhinitis.
It is yet a further additional object of the present invention to provide foods and drinks containing a novel anti-inflammatory agent free from any substantive adverse effects.
It is still more additional object of the present invention to provide foods and drinks containing a novel anti-inflammatory agent with high safety to human body in a long-term administration.
Page S
Pf-3065/second application /Herb-Road/CAlmh The present invention was made and the above objects were achieved based on a long-term experiment in the oriental medicine of the present inventor for thirty five years.
An anti-inflammatory agent exhibiting an anti-inflammatory function is provided, which includes either a set of dried substances or an extract of Perilla leaf, Cacao arid Fennel, and preferably Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed. This specific set or combination of those natural herbs is important and essential for the present invention to provide desired superior anti-inflammatory effects, for example, to relax and suppress symptoms of allergy, particularly holistic symptoms of allergic rhinitis, without causing any substantive adverse effects. Since all of the ingredients included in the anti-inflammatory agent are derived from the natural herbs which are highly safe to human body, a long-term administration of the anti-inflammatory agent may cause substantively no adverse effects. Also, foods and drinks containing the anti-inflammatory agent are also provided.
The above and other objects, features and advantages of the present invention will be apparent from the following descriptions.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
A primary aspect of the present invention is to provide an anti-inflammatory agent exhibiting an anti-inflammatory function, wherein the anti-inflammatory agent includes a set of dried substances of Perilla leaf, Pf 3065/second application /Herb-Road/CA/mh Cacao and Fennel, and preferably Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed. This specific set or combination of those natural herbs is important and essential for the present invention to provide desired superior anti-inflammatory effects, for example, to relax and suppress symptoms of allergy, particularly holistic symptoms of allergic rhinitis, without causing any substantive adverse effects. Since all of the ingredients included in the anti-inflammatory agent are derived from the natural herbs which are highly safe to human body, a long-term administration of the anti-inflammatory agent may cause substantively no adverse effects.
The anti-inflammatory agent may practically be prepared by blending or mixing those herbs in particular conditions that respective ranges of relative ratios in weight of the dried substances of Perilla leaf, Cacao and Fennel are 6~2 : 6~2 : 4~1. In the practical preparation for the agent, typically, those respective relative ratios in weight of the dried substances of Perilla leaf, Cacao and Fennel may be 3 : 3 : 2.
The anti-inflammatory agent may practically be prepared by blending or mixing those herbs in particular conditions that respective ranges of relative ratios in weight of the dried substances of Perilla leaf, Cacav, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed are 6--2 : 6~2 : 4-1 : 4~1 : 4~1 : 4~1 : 30.3. In the practical preparation for the agent, typically, those respective relative ratios in weight of the dried substances of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed may be 3 : 3 : 2 : 2 : 2 : 2 : 1.
Pf-3065/second application /Herb-Road/CA/mh In the practical preparation for the agent, the dried substances may preferably and conveniently be in the form of mixed dry powders.
Optionally, it may be possible to add a sweetness-providing natural herb, for example, Stevia to the above anti-inflammatory agent, wherein respective ranges of relative ratios in weight of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry, Celery seed and Stevia are 6.-2 : 6~2 : 4~I : 4~1 : 4--1 : 4~1 : 30.3 : 30.3.
In the practical administration of the agent, an appropriate dose depends on the state of disease, and patient's age and other factors. One typical example of the daily dose may be in the range of 15-25g.
Another primary aspect of the present invention is to provide an anti-inflammatory agent exhibiting an anti-inflammatory function, wherein the anti-inflammatory agent includes an extract extracted from Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed.
This specific set or combination of those natural herbs is important and essential for the present invention to provide desired superior anti-inflammatory effects, for example, to relax and suppress symptoms of allergy, particularly holistic symptoms of allergic rhinitis, without causing any substantive adverse effects. Since all of the ingredients included in the anti-inflammatory agent are derived from the natural herbs which are highly safe to human body, a long-term administration of the anti-inflammatory agent may cause substantively no adverse effects.
In the practical preparation, the above specific extract may be extracted by a hot water from a set of dried substances of Perilla leaf, Pf-3065/second application /Herb-Road/CA/mh Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed.
Those dried substances may be obtained by either directly drying those herbs in the original or crude shape, or in combination of subsequent grinding the dried herbs into dry powders. The practical extraction may, typically, be made by using a hot water of a temperature in the range of 90-100°C and for a time in the range of 30-SO minutes. A weight ratio of the hot water with reference to the set of dried substances of those herbs may be, but not limited to, in the range of 10-100 times, and preferably 15-25 in the extraction-operation and efficiency points of view.
The above extract included in the agent may be either in a dry-state and a liquid state. The dry-state extract may practically be obtained by drying the liquid state-extract extracted by the hot water. The available dry processes are, for example, spray-dry and freeze-dry to form a granular extract.
Similarly to the first primary aspect, it may optionally be possible to add Stevia as a natural herb sweetener to the agent.
In the practical administration of the agent, an appropriate dose depends on the state of disease, and patient's age and other factors. One typical example of the daily dose may be in the range of, but not limited to, 15-ZSg.
Still another aspect of the present invention is to provide food and drink including an effective ingredient which comprises the novel anti-inflammatory agent described above in connection with the first primary and second primary aspects of the present invention. One typical example Pf-3065/second application /Herb-Road/CA/mh of the practical amount of the effective ingredient included in food and drink may be in the range of, but not limited to, 1-20 percents by weight.
Applicable foods and drinks are any foods and drinks which may include, but not limited to, general foods and drinks, health foods and drinks, and nutritionally supplemental foods and drinks. Typical examples of the general foods and drinks may include various soups, various beverages such as juices, liquors, mineral waters, coffees and teas, various confectioneries such as gum, candy, chocolate, snack and jelly, and various noodles such as buckwheat noodle, Japanese wheat noodle, Chinese wheat noodle, and pasta. Intake of those foods and drinks in the daily diets is effective for prevention and relaxation of the allergic symptoms in the long-term without causing any substantive adverse effect. The very long-term intake of those foods and drinks in the daily diets may ameliorate allergic predisposition.
In Japanese laid-open patent publication No. 9-87189 which is hereby incorporated as reference, it is disclosed that extracts from Labiatae plant such as leaf, flower and root thereof have anti-allergic functions.
In contrast, the present inventor discovered that the above-described specific set or combination of the natural herbs is important and essential to provide desired superior anti-inflammatory effects, for example, to relax and suppress symptoms of allergy, particularly holistic symptoms of allergic rhinitis, without causing any substantive adverse effects. Since all of the ingredients included in the anti-inflammatory agent are derived from the natural herbs which are highly safe to human body, a long-term Pf 3065/second application /Herb-Road/CAJmh administration of the anti-inflammatory agent may cause substantively no adverse effects.
The following examples are typical examples for practicing the foregoing aspects of the present invention. Although the subject matters of the present invention have been described in details, the following additional descriptions in one or more typical preferred embodiments or examples will be made for making it easy to understand the typical modes for practicing the foregoing aspects of the present invention.
E~P1 ~F~~L~Raration of anti-inflammatory ag_en 1 In one preferred example of the present invention, an anti-inflammatory agent was prepared by blending dry powers of the dry herbs at specific weight ratios as follows.
3g of Perilla leaf, 3g of Cacao, 2g of Fennel, 2g of Fenugreek seed, 2g of Rosemary, Zg of Juniper berry, 1g of Celery seed and 0.7g of Stevia were mixed in dry-powered state to prepare the anti-inflammatory agent. This anti-inflammatory agent will be refereed to as the anti-inflammatory agent of example 1 of the present invention.
F.~X ,MpLE 2 : ~(~rypar~tion of an i-infl ma ory a entl In one preferred example of the present invention, an anti-inflammatory agent was prepared by blending dry powers of the dry herbs at specific weight ratios as follows.
3g of Perilla leaf, 3g of Cacao and 2g of Fennel were mixed in Pf-3065/second application /Herb-Road/CAlmh dry-powered state to prepare the anti-inflammatory agent. This anti-inflammatory agent will be refereed to as the anti-inflammatory agent of example 2 of the present invention.
COMPARATIVE EXAMPj,E 7 :~~renaration of anti-inflammatory agentl In one comparative-example of the prior art, an anti-inflammatory agent was prepared by blending dry powers of the dry herbs at specific weight ratios as follows.
3g of Perilla leaf and 2g of Rosemary were mixed in dry-powered state to prepare the anti-inflammatory agent. This anti-inflammatory agent will be refereed to as the anti-inflammatory agent of comparative example 1.
In another comparative-example of the prior art, an anti-inflammatory agent was prepared by blending dry powers of the dry herbs at specific weight ratios as follows.
3g of Cacao and 2g of Fennel were mixed in dry-powered state to prepare the anti-inflammatory agent. This anti-inflammatory agent will be refereed to as the anti-inflammatory agent of comparative example 2.
37-patients of cryptomeria pollen disease with sneeze and rhinitis symptoms seasonally appeared in February through May and/or other 1'agc 12 Pf-3065/second application /f~ierb-Road/CAJmh allergic diseases continuously appeared throughout the year were treated as follows.
A first group of 31 cases of the 42-patients administrated daily two times an extract which was extracted by a hot water of 10090 for 35 minutes from the anti-inflammatory agent of example 1 of the present invention.
A second group of 5 cases of the 42-patients administrated daily two times an extract which was extracted by a hot water of 10090 for 35 minutes from the anti-inflammatory agent of example 2 of the present invention.
A third group of other 3 cases administrated daily two times an extract which was extracted by a hot water of 100°0 for 35 minutes from the anti-inflammatory agent of comparative example 1.
A fourth group of the remaining 3 cases administrated daily two times an extract which was extracted by a hot water of 100°~C for 35 minutes from the anti-inflammatory agent of comparative example 2.
The above administrations were continued for four weeks and then the evaluations were made on the basis of the following criterions.
"A" : Remarkably effective : all of the symptoms were disappeared "B" : Effective : most of the symptoms were disappeared, but a few symptoms sill resided "C" : Somewhat effective : only a few symptoms were disappeared but most of the symptoms sill resided "D" : Not effective : none of any significant effect was confirmed.
Pf 30b5/second application /Herb-Road/CA/mh The results of the evaluations are shown on the following Table 1.
criterio ns "A " "B " " C" "D"
first gr oan 14 cases9 cases5 cases'~ cases second g~~ 2 cases1 case 0 case 0 case thiy ~~ 0 case 0 yase 1 case 2 cases g , r,~p 0 cad 0 case 0 case 3 cases fount From the first group, it was demonstrated that administration of the anti-inflammatory agent of example 1 of the present invention is, in most cases, significantly effective to relax and suppress the cryptomeria pollen symptoms and other permanent allergic symptoms. In addition, it was also confirmed that all of the 31 cases of the first group were free from any adverse effects. A certain amelioration in the cryptomeria pollen symptoms and other permanent allergic symptoms was initiated on third day from the start of the administration. One week after the start of administration, most of the 31 cases of the first group subjectively felt a certain reduction in cryptomeria pollen symptoms and other permanent allergic symptoms. 1'wo weeks after the start of administration, the above remarkable effectiveness to relax and suppress the cryptomeria pollen symptoms and other permanent allergic symptoms was confirmed.
Pf 3065/second application /Herb-Road/CAJmh In addition, from the second group, it was demonstrated that administration of the anti-inflammatory agent of example 1 of the present invention is, some cases, significantly effective to relax and suppress the cryptomeria pollen symptoms and other permanent allergic symptoms. It was also confirmed that all of the 5 cases of the first group were free from any adverse effects. A certain amelioration in the cryptomeria pollen symptoms and other permanent allergic symptoms was initiated on third day from the start of the administration. One week after the start of administration, a majority of the 5 cases of the second group subjectively felt a certain reduction in cryptomeria pollen symptoms and other permanent allergic symptoms. ~vo weeks after the start of administration, the above remarkable effectiveness to relax and suppress the cryptomeria pollen symptoms and other permanent allergic symptoms was confirmed.
In contrast, the third and fourth groups demonstrated that either administration of the anti-inflammatory agents of comparative examples 1 and 2 is not substantially effective to relax and suppress the cryptomeria pollen symptoms and other permanent allergic symptoms.
In conclusion, the above text demonstrated that the above-described specific set or combination of the natural herbs is important and essential to provide desired superior anti-inflammatory effects, for example, to relax and suppress symptoms of allergy, particularly holistic symptoms of allergic rhinitis, without causing any substantive adverse effects.
Pf 3065/second application /Herb-Road/CA~/mh In another preferred example of the present invention, a soup containing the above-described anti-inflammatory agent of example 1 of the present invention was prepared, wherein the ingredients of the soup were 20 wt-% of the anti-inflammatory agent, 30 wt-% of green gram, 1.5 wt-% of Stevia, 1 wt-% of salt and 47.5 wt-% of water.
From this example, it was demonstrated that inclusion of the anti-inflammatory agent into the foods and drinks, which may be taken by daily diets, is practically useful for habitual intake of the anti-inflammatory agent for a long-term, for example, throughout the year in order to previously prevent allergic disease and ameliorate allergic predisposition.
Although the invention has been described above in connection with several preferred embodiments therefor, it will be appreciated that those embodiments have been provided solely for illustrating the invention, and not in a limiting sense. Numerous modiftcations and substitutions of equivalent materials and techniques will be readily apparent to those skilled in the art after reading the present application, and all such modifications and substitutions are expressly understood to fall within the true scope and spirit of the appended claims.
Page 1b
Claims (43)
1. An anti-inflammatory agent exhibiting an anti-inflammatory function, wherein said anti-inflammatory agent includes a set of dried substances of Perilla leaf, Cacao, and Fennel,
2. The agent as claimed in claim 1, wherein respective ranges of relative ratios in weight of said dried substances of Perilla leaf, Cacao and Fennel are 6~2 : 6~2 : 4~1.
3. The agent as claimed in claim 2, wherein respective relative ratios in weight of said dried substances of Perilla leaf, Cacao and Fennel are 3:3:2.
4. The agent as claimed in claim 1, wherein said dried substances are in the form of mixed dry powders.
5. The agent as claimed in claim 1, wherein said anti-inflammatory agent includes a set of dried substances of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed.
6. The agent as claimed in claim 5, wherein respective ranges of relative ratios in weight of said dried substances of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed are 6~2:
6~2 : 4~1 : 4~1 : 4~1 : 4~1 : 3~0.3.
6~2 : 4~1 : 4~1 : 4~1 : 4~1 : 3~0.3.
7. The agent as claimed in claim 6, wherein respective relative ratios in weight of said dried substances of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed are 3 : 3 : 2 : 2 2:2:1.
8. The agent as claimed in claim 5, wherein said dried substances are in the form of mixed dry powders.
9. An anti-inflammatory agent exhibiting an anti-inflammatory function, wherein said anti-inflammatory agent includes an extract extracted from Perilla leaf, Cacao and Fennel.
10. The agent as claimed in claim 9, wherein said extract comprises a liquid-state extract extracted by a hot water.
11. The agent as claimed in claim 10, wherein said extraction by said hot water is made from a set of dried substances of Perilla leaf, Cacao and Fennel.
12. The agent as claimed in claim 11, wherein said extraction is made at a temperature in the range of 90-100 and for a time in the range of 30-50 minutes.
13. The agent as claimed in claim 12, wherein a weight ratio of said hot water with reference to said set of dried substances is in the range of 10-100.
14. The agent as claimed in claim 9, wherein said anti-inflammatory agent includes an extract extracted from Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed.
15. The agent as claimed in claim 14, wherein said extract comprises a liquid-state extract extracted by a hot water.
16. The agent as claimed in claim 15, wherein said extraction by said hot water is made from a set of dried substances of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed.
17. The agent as claimed in claim 16, wherein said extraction is made at a temperature in the range of 90-100°C and for a time in the range of 30-50 minutes.
18. The agent as claimed in claim 17, wherein a weight ratio of said hot water with reference to said set of dried substances is in the range of
19 10-100.
19. The agent as claimed in claim 14, wherein said extract comprises a dry-state extract obtained by drying a liquid state-extract extracted by a hot water.
19. The agent as claimed in claim 14, wherein said extract comprises a dry-state extract obtained by drying a liquid state-extract extracted by a hot water.
20. Food and drink including an effective ingredient which comprises an anti-inflammatory agent exhibiting an anti-inflammatory function, wherein said anti-inflammatory agent includes a set of dried substances of Perilla leaf, Cacao and Fennel.
21. Food and drink as claimed in claim 20, wherein respective ranges of relative ratios in weight of said dried substances of Perilla leaf, Cacao and Fennel are 6~2 : b~2 : 4~1.
22. Food and drink as claimed in claim 21, wherein respective relative ratios in weight of said dried substances of Perilla leaf, Cacao and Fennel are 3 : 3 : 2.
23. Food and drink as claimed in claim 20, wherein said dried substances are in the form of mixed dry powders.
24. Food and drink as claimed in claim 20, wherein said effective ingredient is included in the range of 1-20 percents by weight.
25. Food and drink as claimed in claim 20, wherein said anti-inflammatory agent includes a set of dried substances of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed.
26. Food and drink as claimed in claim 25, wherein respective ranges of relative ratios in weight of said dried substances of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed are 6~2:
6~2 : 4~1 : 4~1 : 4~1 : 4~1 : 3~0.3.
6~2 : 4~1 : 4~1 : 4~1 : 4~1 : 3~0.3.
27. Food and drink as claimed in claim 26, wherein respective relative ratios in weight of said dried substances of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed are 3 3:2:2:2:2:1.
28. Food and drink as claimed in claim 25, wherein said dried substances are in the form of mixed dry powders.
29. Food and drink as claimed in claim 25, wherein said effective ingredient is included in the range of 1-20 percents by weight.
30. Food and drink including an effective ingredient which comprises an anti-inflammatory agent exhibiting an anti-inflammatory function, wherein said anti-inflammatory agent includes an extract extracted from Perilla leaf, Cacao and Fennel.
31. Food and drink as claimed in claim 30, wherein said extract comprises a liquid-state extract extracted by a hot water.
32. Food and drink as claimed in claim 31, wherein said extraction by said hot water is made from a set of dried substances of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed.
33. Food and drink as claimed in claim 32, wherein said extraction is made at a temperature in the range of 90-100°C and for a time in the range of 30-50 minutes.
34. Food and drink as claimed in claim 33, wherein a weight ratio of said hot water with reference to said set of dried substances is in the range of 10-100.
35. Food and drink as claimed in claim 30, wherein said extract comprises a dry-state extract obtained by drying a liquid state-extract extracted by a hot water.
36. Food and drink as claimed in claim 30, wherein said effective ingredient is included in the range of 1-20 percents by weight.
37. Food and drink as claimed in claim 30, wherein said anti-inflammatory agent includes an extract extracted from Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed.
38. Food and drink as claimed in claim 37, wherein said extract comprises a liquid-state extract extracted by a hot water.
39. Food and drink as claimed in claim 38, wherein said extraction by said hot water is made from a set of dried substances of Perilla leaf, Cacao, Fennel, Fenugreek seed, Rosemary, Juniper berry and Celery seed.
40, Food and drink as claimed in claim 39, wherein said extraction is made at a temperature in the range of 90-100°C and for a time in the range of 30-50 minutes.
41. Food and drink as claimed in claim 40, wherein a weight ratio of said hot water with reference to said set of dried substances is in the range of 10-100.
42. Food and drink as claimed in claim 39, wherein said extract comprises a dry-state extract obtained by drying a liquid state-extract extracted by a hot water.
43. Food and drink as claimed in claim 39, wherein said effective ingredient is included in the range of 1-20 percents by weight.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001-329049 | 2001-10-26 | ||
| JP2001329049 | 2001-10-26 | ||
| JP2002-244913 | 2002-08-26 | ||
| JP2002244913A JP2003201246A (en) | 2001-10-26 | 2002-08-26 | Antiinflammatory agent, and food and drink containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2409084A1 true CA2409084A1 (en) | 2003-04-26 |
Family
ID=26624130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2409084 Abandoned CA2409084A1 (en) | 2001-10-26 | 2002-10-21 | Anti-inflammatory agent and foods and drinks containing the same |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2003201246A (en) |
| CA (1) | CA2409084A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7384654B2 (en) | 2004-02-05 | 2008-06-10 | Access Business Group International Llc | Anti-Allergy composition and related method |
| US20060134025A1 (en) * | 2004-12-17 | 2006-06-22 | Colgate-Palmolive Company | Oral compositions containing extracts of Rosmarinus and related methods |
| WO2007007958A1 (en) * | 2005-07-08 | 2007-01-18 | Yuhan Corporation | Herbal pharmaceutical composition for regenerative agent of cartilaginous tissue and treatment of osteoarthritis |
| JP5372358B2 (en) * | 2007-01-20 | 2013-12-18 | 美智士 谷 | Bioactive therapeutic substance |
| JP7617709B2 (en) | 2020-04-02 | 2025-01-20 | ヱスビー食品株式会社 | Nitric oxide production inhibitor and food composition for inhibiting nitric oxide production |
-
2002
- 2002-08-26 JP JP2002244913A patent/JP2003201246A/en active Pending
- 2002-10-21 CA CA 2409084 patent/CA2409084A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003201246A (en) | 2003-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103005095B (en) | Heat-clearing, detoxifying and blood-pressure-reducing tea and preparation method | |
| CN106975069A (en) | A kind of liver protecting composition and preparation method thereof | |
| Mekala et al. | Phytochemical screening and pharmacological update on Kabasura Kudineer choornam and Nilavembu Kudineer Choornam | |
| CN104147385B (en) | A kind of formula of Chinese medicine for lowering blood pressure preparation and preparation method | |
| KR20190045057A (en) | Dietary herbal composition for improving obesity and method for producing the same | |
| RU2604787C1 (en) | Phytotea "avan" | |
| CN103417682B (en) | Traditional Chinese medicine preparation for reducing blood pressure and preparation method thereof | |
| CA2409084A1 (en) | Anti-inflammatory agent and foods and drinks containing the same | |
| US6884442B2 (en) | Anti-inflammatory agent and foods and drinks containing the same | |
| US20030082245A1 (en) | Anti-inflammatory agent and foods and drinks containing the same | |
| RU2435450C1 (en) | Biologically active dietary supplement origitea® ochischeniye vecher | |
| US20190160126A1 (en) | Compositions and methods for treating reproductive indicators symptomatic of male infertility | |
| RU2097994C1 (en) | Composition for preparing curative-and-prophylactic drink | |
| US20050031712A1 (en) | Agent for suppressing or preventing gastralgia, and composition for food or beverage | |
| KR20190045073A (en) | Dietary herbal composition for improving obesity and method for producing the same | |
| RU2074244C1 (en) | Component composition for balsam | |
| CN101829181A (en) | Extract of the effective-part of Gynostemma pentaphyllum and preparation method thereof | |
| RU2164802C1 (en) | Agent for treatment of patients with hepatitis and fibrosis symptoms | |
| RU2673042C2 (en) | Health-improvement drink powder | |
| CN104323388A (en) | Beverage stock solution, chrysanthemum seedling composite plant beverage and preparation method of beverage | |
| KR102222174B1 (en) | Pills using a concentrate of acori graminei rhizoma and a method of manufaturing the same | |
| CN103784600B (en) | Strengthen the Chinese herbal medicament oral liquid of recoon dog immunity | |
| JP7777895B2 (en) | Food composition containing bitterness suppressant | |
| WO2021221577A2 (en) | Formulations of food supplement comprising natural sweetener | |
| EP3509430B1 (en) | Herbal beverage and method of its preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |