CA2477842A1 - Inhibition de la kinase jun - Google Patents
Inhibition de la kinase jun Download PDFInfo
- Publication number
- CA2477842A1 CA2477842A1 CA002477842A CA2477842A CA2477842A1 CA 2477842 A1 CA2477842 A1 CA 2477842A1 CA 002477842 A CA002477842 A CA 002477842A CA 2477842 A CA2477842 A CA 2477842A CA 2477842 A1 CA2477842 A1 CA 2477842A1
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- Prior art keywords
- jnk
- mice
- jnkl
- insulin resistance
- jnk1
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne un procédé permettant de traiter un trouble métabolique associé à la résistance à l'insuline. Ce procédé consiste à administrer à un mammifère un inhibiteur d'une kinase JNK (NH2-terminal Jun Kinase), par exemple, un composé ou un peptide qui inhibe l'expression de JNK1 ou l'activité enzymatique.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28596601P | 2001-04-24 | 2001-04-24 | |
| US60/285,966 | 2001-04-24 | ||
| PCT/US2002/012687 WO2002085396A1 (fr) | 2001-04-24 | 2002-04-24 | Inhibition de la kinase jun |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2477842A1 true CA2477842A1 (fr) | 2002-10-31 |
Family
ID=23096452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002477842A Abandoned CA2477842A1 (fr) | 2001-04-24 | 2002-04-24 | Inhibition de la kinase jun |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1390052A4 (fr) |
| CA (1) | CA2477842A1 (fr) |
| WO (1) | WO2002085396A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7119114B1 (en) | 1999-08-19 | 2006-10-10 | Signal Pharmaceuticals, Llc | Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto |
| US20040072888A1 (en) | 1999-08-19 | 2004-04-15 | Bennett Brydon L. | Methods for treating inflammatory conditions or inhibiting JNK |
| US7211594B2 (en) | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
| US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| US7429599B2 (en) | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
| US6987184B2 (en) | 2001-02-15 | 2006-01-17 | Signal Pharmaceuticals, Llc | Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related |
| US7351729B2 (en) | 2002-03-08 | 2008-04-01 | Signal Pharmaceuticals, Llc | JNK inhibitors for use in combination therapy for treating or managing proliferative disorders and cancers |
| EP2065383A1 (fr) | 2003-11-19 | 2009-06-03 | Signal Pharmaceuticals, Inc. | Composés d'indazoles et procédés d'utilisation associés en tant qu'inhibiteurs de kinase de protéine |
| JP4686704B2 (ja) | 2004-08-24 | 2011-05-25 | 国立大学法人山口大学 | 動脈瘤予防および／または治療剤 |
| EP1799263A4 (fr) * | 2004-09-15 | 2009-07-29 | Harvard College | Reduction du stress du re dans le traitement de l'obesite et du diabete |
| US20060223807A1 (en) | 2005-03-29 | 2006-10-05 | University Of Massachusetts Medical School, A Massachusetts Corporation | Therapeutic methods for type I diabetes |
| WO2008016995A2 (fr) * | 2006-08-01 | 2008-02-07 | Joslin Diabetes Center, Inc. | Procédés d'identification de modulateurs de la signalisation de l'insuline |
| US20080194575A1 (en) * | 2006-10-04 | 2008-08-14 | Naiara Beraza | Treatment for non-alcoholic-steatohepatitis |
| US9956236B2 (en) | 2011-02-07 | 2018-05-01 | Cornell University | Methods for increasing immune responses using agents that directly bind to and activate IRE-1 |
| CN102676466A (zh) * | 2011-03-17 | 2012-09-19 | 南京大学 | 一种突变型jnk1序列及其质粒的应用 |
| EP3521431A1 (fr) | 2013-09-25 | 2019-08-07 | Cornell University | Composés pour induire l'immunité antitumorale et procédés associés |
| WO2015138426A1 (fr) * | 2014-03-10 | 2015-09-17 | Croce Carlo M | Compositions et méthodes permettant de traiter la cachexie |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6635994A (en) * | 1993-04-16 | 1994-11-08 | Tufts University School Of Medicine | Method for treatment of menopausal and premenstrual symptoms |
| US5506211A (en) * | 1994-05-09 | 1996-04-09 | The Uab Research Foundation | Genistein for use in inhibiting osteroclasts |
| ATE212552T1 (de) * | 1998-04-17 | 2002-02-15 | Tufts College | Map kinase-inhibitoren zur behandlung von durch tnf-alpha induzierte lipolyse- verursachte krankheiten |
-
2002
- 2002-04-24 WO PCT/US2002/012687 patent/WO2002085396A1/fr not_active Ceased
- 2002-04-24 CA CA002477842A patent/CA2477842A1/fr not_active Abandoned
- 2002-04-24 EP EP02764295A patent/EP1390052A4/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1390052A4 (fr) | 2008-10-08 |
| EP1390052A1 (fr) | 2004-02-25 |
| WO2002085396A1 (fr) | 2002-10-31 |
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