CA2474852A1 - Utilisation d'inhibiteurs pde5 dans le traitement de la cicatrisation et de la fibrose - Google Patents
Utilisation d'inhibiteurs pde5 dans le traitement de la cicatrisation et de la fibrose Download PDFInfo
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- CA2474852A1 CA2474852A1 CA002474852A CA2474852A CA2474852A1 CA 2474852 A1 CA2474852 A1 CA 2474852A1 CA 002474852 A CA002474852 A CA 002474852A CA 2474852 A CA2474852 A CA 2474852A CA 2474852 A1 CA2474852 A1 CA 2474852A1
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- fibrosis
- inhibitor
- scarring
- chronic
- ageing
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Abstract
L'invention concerne l'utilisation d'inhibiteurs sélectifs de la guanosine 3', 5'-monophosphate cyclique du type cinq (cGMP PDE5} (ci-après dénommés inhibiteurs de PDE5), comprenant notamment le composé sildénafil, pour le traitement ou la prévention de la formation de cicatrices et de la fibrose au niveau du tissu.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0202254.9A GB0202254D0 (en) | 2002-01-31 | 2002-01-31 | Prevention of scarring |
| GB0202254.9 | 2002-01-31 | ||
| PCT/IB2003/000134 WO2003063875A1 (fr) | 2002-01-31 | 2003-01-21 | Utilisation des inhibiteurs de pde5 dans le traitement de la formation de cicatrices et de la fibrose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2474852A1 true CA2474852A1 (fr) | 2003-08-07 |
Family
ID=9930135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002474852A Abandoned CA2474852A1 (fr) | 2002-01-31 | 2003-01-21 | Utilisation d'inhibiteurs pde5 dans le traitement de la cicatrisation et de la fibrose |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1469857A1 (fr) |
| JP (1) | JP2005523263A (fr) |
| BR (1) | BR0307410A (fr) |
| CA (1) | CA2474852A1 (fr) |
| GB (1) | GB0202254D0 (fr) |
| MX (1) | MXPA04007430A (fr) |
| TW (1) | TW200302105A (fr) |
| WO (1) | WO2003063875A1 (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA012279B1 (ru) * | 2003-05-22 | 2009-08-28 | Никомед Гмбх | Композиция, включающая ингибитор pde4 и ингибитор pde5 |
| EP1786428B1 (fr) | 2004-08-17 | 2012-05-16 | The Johns Hopkins University | Compositions d'inhibiteur pde5 et methodes de traitement des troubles cardiaques |
| EP1759700B1 (fr) * | 2004-08-19 | 2009-08-05 | Switch Biotech, LLC | Utilisation d'inhibiteurs de PDE5 pour traiter et prévenir les maladies liées à la hypopigmentation |
| AU2005274546B2 (en) * | 2004-08-19 | 2011-02-03 | Switch Biotech, Llc | Use of a PDE5 inhibitor for treating and preventing hypopigmentary disorders |
| US20090074796A1 (en) | 2005-01-07 | 2009-03-19 | The John Hopkins University | Pde5 inhibitor compositions and methods for immunotherapy |
| DE102005001989A1 (de) * | 2005-01-15 | 2006-07-20 | Bayer Healthcare Ag | Intravenöse Formulierungen von PDE-Inhibitoren |
| EP1874316A1 (fr) * | 2005-04-18 | 2008-01-09 | Associazione Foresta Per La Ricerca Nella Riproduzione Umana | Utilisation d'inhibiteurs pde-5 pour reparer des tissus endommages par un trauma ou par une maladie |
| MX2007015365A (es) | 2005-06-10 | 2008-02-12 | Dong A Pharm Co Ltd | Agente para la prevencion y tratamiento de enfermedades hepaticas que contienen el derivado de pirazolopirimidina. |
| AR079451A1 (es) | 2009-12-18 | 2012-01-25 | Nycomed Gmbh | Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina |
| CN102970965A (zh) * | 2010-04-05 | 2013-03-13 | Sk化学公司 | 含有pde5抑制剂的减少皮肤皱纹的合成物 |
| MA34249B1 (fr) | 2010-05-26 | 2013-05-02 | Bayer Ip Gmbh | Utilisation de stimulateurs de la sgc, d'activateurs de la sgc, seuls et en association avec des inhibiteurs de la pde5 en vue du traitement de la sclérodermie systémique |
| JP2014526461A (ja) * | 2011-09-09 | 2014-10-06 | エスケー ケミカルズ カンパニー，リミテッド | Ｐｄｅ５抑制剤を含む皮膚しわ改善用組成物 |
| AT512084A1 (de) | 2011-10-20 | 2013-05-15 | Univ Wien Tech | Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren |
| EP2938343B1 (fr) | 2012-12-21 | 2018-09-12 | Mayo Foundation For Medical Education And Research | Procédés et matériaux pour le traitement de la sténose valvulaire aortique calcifiée |
| EP2992885A3 (fr) * | 2014-09-02 | 2016-05-18 | Jansfat Biotechnology Co., Ltd. | Procédé d'inhibition d'une maladie du foie |
| US20200069549A1 (en) | 2017-03-14 | 2020-03-05 | Atir Holding S.A. | Topical formulation for the treatment of pigmented skin |
| CA3055881C (fr) | 2017-03-14 | 2021-04-06 | Atir Holding S.A. | Utilisation de composes heterocycliques dans le traitement de la peau pigmentee |
| MX2017016930A (es) * | 2017-12-19 | 2019-06-20 | Malesil Research & Tech Llc | Uso del maleato de sildenafil en el tratamiento de ulceras de pie diabetico. |
| CN114144229A (zh) | 2019-04-10 | 2022-03-04 | 梅约医学教育与研究基金会 | 心血管功能障碍的性别依赖性治疗方法和材料 |
| CN112773898A (zh) * | 2019-11-11 | 2021-05-11 | 广州华真医药科技有限公司 | 磷酸二酯酶5抑制剂在制备抗纤维化疾病药物中的应用 |
| EP4384176A1 (fr) * | 2021-08-13 | 2024-06-19 | Mezzion Pharma Co., Ltd. | Méthodes et compositions permettant de traiter des affections hépatiques fibrotiques, à l'aide de compositions d'udénafil |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| US5965501A (en) * | 1997-03-28 | 1999-10-12 | Lever Brothers Company, Division Of Conopco, Inc. | Personal washing bar compositions comprising emollient rich phase/stripe |
| WO1999026946A1 (fr) * | 1997-11-26 | 1999-06-03 | Mochida Pharmaceutical Co., Ltd. | DERIVES DE PYRIDOCARBAZOLE A ACTIVITE INHIBITRICE SUR LA cGMP-PDE |
| ZA9810766B (en) * | 1997-11-28 | 1999-05-25 | Mochida Pharm Co Ltd | Novel compounds having cgmp-pde inhibitory activity |
| GB9909135D0 (en) * | 1999-04-22 | 1999-06-16 | Univ Wales Medicine | Cystic fibrosis medicaments |
| US6503908B1 (en) * | 1999-10-11 | 2003-01-07 | Pfizer Inc | Pharmaceutically active compounds |
| GB9930570D0 (en) * | 1999-12-23 | 2000-02-16 | Pfizer Ltd | Therapy |
-
2002
- 2002-01-31 GB GBGB0202254.9A patent/GB0202254D0/en not_active Ceased
-
2003
- 2003-01-21 WO PCT/IB2003/000134 patent/WO2003063875A1/fr not_active Ceased
- 2003-01-21 EP EP20030734608 patent/EP1469857A1/fr not_active Withdrawn
- 2003-01-21 CA CA002474852A patent/CA2474852A1/fr not_active Abandoned
- 2003-01-21 JP JP2003563565A patent/JP2005523263A/ja active Pending
- 2003-01-21 BR BR0307410-2A patent/BR0307410A/pt not_active IP Right Cessation
- 2003-01-21 MX MXPA04007430A patent/MXPA04007430A/es unknown
- 2003-01-24 TW TW092101618A patent/TW200302105A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1469857A1 (fr) | 2004-10-27 |
| GB0202254D0 (en) | 2002-03-20 |
| TW200302105A (en) | 2003-08-01 |
| WO2003063875A1 (fr) | 2003-08-07 |
| BR0307410A (pt) | 2004-12-28 |
| JP2005523263A (ja) | 2005-08-04 |
| MXPA04007430A (es) | 2005-06-20 |
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