CA2466032A1 - Methodes et formes posologiques permettant d'ameliorer la biodisponibilite d'agents therapeutiques - Google Patents
Methodes et formes posologiques permettant d'ameliorer la biodisponibilite d'agents therapeutiques Download PDFInfo
- Publication number
- CA2466032A1 CA2466032A1 CA002466032A CA2466032A CA2466032A1 CA 2466032 A1 CA2466032 A1 CA 2466032A1 CA 002466032 A CA002466032 A CA 002466032A CA 2466032 A CA2466032 A CA 2466032A CA 2466032 A1 CA2466032 A1 CA 2466032A1
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- OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 229960005249 misoprostol Drugs 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229960001085 piretanide Drugs 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- XHKUDCCTVQUHJQ-LCYSNFERSA-N quinidine D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 XHKUDCCTVQUHJQ-LCYSNFERSA-N 0.000 description 1
- 229960002454 quinidine gluconate Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000019231 riboflavin-5'-phosphate Nutrition 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 229960002370 sotalol Drugs 0.000 description 1
- ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229960000351 terfenadine Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- NZHGWWWHIYHZNX-CSKARUKUSA-N tranilast Chemical compound C1=C(OC)C(OC)=CC=C1\C=C\C(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-CSKARUKUSA-N 0.000 description 1
- 229960005342 tranilast Drugs 0.000 description 1
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 1
- 229960001661 ursodiol Drugs 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Physiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Vascular Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
La présente invention se rapporte à des formes posologiques à libération contrôlée destinées à une administration orale. Cette forme posologique comprend un agent thérapeutique qui est métabolisé dans le tractus gastro-intestinal supérieur en combinaison à un agent à libération contrôlée de manière à être hydrodynamiquement équilibrée afin que, lors du contact avec le fluide gastrique, ladite forme posologique possède une densité apparente inférieure à 1 g/ml et par conséquent s'avère susceptible de flotter dans le fluide gastrique. Cette forme posologique est retenue dans l'estomac pendant le laps de temps lui permettant de libérer sensiblement tous les médicaments qu'elle contient. En outre, cette forme posologique permet une libération du médicament pendant un laps de temps prolongé de sorte que l'administration de l'agent thérapeutique à l'intestin grêle se déroule de manière régulière plutôt que subite. Cette libération régulière dans le temps de l'agent thérapeutique au niveau du site de métabolisation et d'absorption permet d'empêcher une saturation enzymatique et favorise par conséquent une meilleure biodisponibilté de l'agent thérapeutique.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01125761.5 | 2001-10-29 | ||
| EP01125761 | 2001-10-29 | ||
| PCT/EP2002/012062 WO2003037296A2 (fr) | 2001-10-29 | 2002-10-29 | Methodes et formes posologiques permettant d'ameliorer la biodisponibilite d'agents therapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2466032A1 true CA2466032A1 (fr) | 2003-05-08 |
Family
ID=8179102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002466032A Abandoned CA2466032A1 (fr) | 2001-10-29 | 2002-10-29 | Methodes et formes posologiques permettant d'ameliorer la biodisponibilite d'agents therapeutiques |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1439820A2 (fr) |
| JP (1) | JP2005509643A (fr) |
| AU (1) | AU2002351798A1 (fr) |
| CA (1) | CA2466032A1 (fr) |
| MX (1) | MXPA04004035A (fr) |
| WO (1) | WO2003037296A2 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007048219A3 (fr) * | 2005-09-09 | 2007-07-19 | Labopharm Inc | Composition medicamenteuse a liberation prolongee |
| US7829120B2 (en) | 2005-09-09 | 2010-11-09 | Labopharm Inc. | Trazodone composition for once a day administration |
| US7988998B2 (en) | 2002-10-25 | 2011-08-02 | Labopharm Inc. | Sustained-release tramadol formulations with 24-hour efficacy |
| US8487002B2 (en) | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5355002B2 (ja) | 2008-09-10 | 2013-11-27 | オリンパスメディカルシステムズ株式会社 | 浮き量合否判定システム、浮き量合否判定用表示システム、浮き量合否判定方法および浮き量合否判定用表示方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0998271B3 (fr) * | 1997-06-06 | 2014-10-29 | Depomed, Inc. | Formes de dosage de medicaments administres par voie orale a retention gastrique pour liberation lente de medicaments hautement solubles |
| DK1107741T3 (da) * | 1998-09-14 | 2003-11-17 | Ranbaxy Lab Ltd | Oralt administreret reguleret administrationssystem, der tilvejebringer tidsmæssig og rumlig regulering |
| AU5060499A (en) * | 1999-08-04 | 2001-03-05 | Ranbaxy Laboratories Limited | Hydrodynamically balanced oral drug delivery system |
| WO2001058424A1 (fr) * | 2000-02-09 | 2001-08-16 | West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited | Composition flottante de liberation de medicament |
-
2002
- 2002-10-29 WO PCT/EP2002/012062 patent/WO2003037296A2/fr not_active Ceased
- 2002-10-29 MX MXPA04004035A patent/MXPA04004035A/es unknown
- 2002-10-29 JP JP2003539640A patent/JP2005509643A/ja not_active Withdrawn
- 2002-10-29 EP EP02787522A patent/EP1439820A2/fr not_active Withdrawn
- 2002-10-29 CA CA002466032A patent/CA2466032A1/fr not_active Abandoned
- 2002-10-29 AU AU2002351798A patent/AU2002351798A1/en not_active Abandoned
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7988998B2 (en) | 2002-10-25 | 2011-08-02 | Labopharm Inc. | Sustained-release tramadol formulations with 24-hour efficacy |
| US8487002B2 (en) | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
| WO2007048219A3 (fr) * | 2005-09-09 | 2007-07-19 | Labopharm Inc | Composition medicamenteuse a liberation prolongee |
| US7829120B2 (en) | 2005-09-09 | 2010-11-09 | Labopharm Inc. | Trazodone composition for once a day administration |
| US8795723B2 (en) | 2005-09-09 | 2014-08-05 | Angelini Pharma Inc. | Sustained drug release compositions |
| US9439866B2 (en) | 2005-09-09 | 2016-09-13 | Angelini Pharma, Inc. | Trazodone composition for once a day administration |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003037296A3 (fr) | 2003-12-24 |
| MXPA04004035A (es) | 2004-10-29 |
| EP1439820A2 (fr) | 2004-07-28 |
| JP2005509643A (ja) | 2005-04-14 |
| WO2003037296A2 (fr) | 2003-05-08 |
| AU2002351798A1 (en) | 2003-05-12 |
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