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CA2463595A1 - Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina) - Google Patents

Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina) Download PDF

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Publication number
CA2463595A1
CA2463595A1 CA002463595A CA2463595A CA2463595A1 CA 2463595 A1 CA2463595 A1 CA 2463595A1 CA 002463595 A CA002463595 A CA 002463595A CA 2463595 A CA2463595 A CA 2463595A CA 2463595 A1 CA2463595 A1 CA 2463595A1
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Canada
Prior art keywords
sina
nucleotides
sina molecule
molecule
bcl2
Prior art date
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Abandoned
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CA002463595A
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English (en)
Inventor
James Mcswiggen
Leonid Beigelman
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Sirna Therapeutics Inc
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Individual
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Publication of CA2463595A1 publication Critical patent/CA2463595A1/fr
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C12N2310/53—Physical structure partially self-complementary or closed

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Abstract

La présente invention concerne des techniques et des réactifs qui conviennent pour moduler l'expression du gène BCL2 dans diverses applications comprenant l'utilisation de ces techniques et de ces réactifs dans une validation de cible thérapeutique et diagnostique et dans des applications de recherche génomique. Cette invention concerne spécifiquement de petites molécules d'acide nucléique telles que de petites molécules d'acide nucléique interférent (siNA), de petites molécules d'ARN interférent (siRNA), des molécules d'ARN double brin (dsRNA), des micro-ARN (miRNA),et de petites molécules d'ARN en épingle à cheveux (shRNA) capables d'induire une interférence ARN (RNAi) contre l'expression des gènes BCL2, BCL-XL, MCL-1, BCL2-Ll, CED-9, BAG-1, ElB-194 et/ou BCL-A. Ces petites molécules conviennent pour le traitement du cancer et d'autres pathologies qui répondent à la modulation de l'expression de BCL2, BCL-XL, MCL-1, BCL2-Ll, CED-9, BAG-1, E1B-194 et/ou BCL-A1.
CA002463595A 2002-02-20 2003-02-18 Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina) Abandoned CA2463595A1 (fr)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US35858002P 2002-02-20 2002-02-20
US60/358,580 2002-02-20
US36312402P 2002-03-11 2002-03-11
US60/363,124 2002-03-11
US38678202P 2002-06-06 2002-06-06
US60/386,782 2002-06-06
US39690502P 2002-07-18 2002-07-18
US60/396,905 2002-07-18
US40678402P 2002-08-29 2002-08-29
US60/406,784 2002-08-29
US40837802P 2002-09-05 2002-09-05
US60/408,378 2002-09-05
US40929302P 2002-09-09 2002-09-09
US60/409,293 2002-09-09
US44012903P 2003-01-15 2003-01-15
US60/440,129 2003-01-15
PCT/US2003/004908 WO2003070969A2 (fr) 2002-02-20 2003-02-18 Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina)

Publications (1)

Publication Number Publication Date
CA2463595A1 true CA2463595A1 (fr) 2003-08-28

Family

ID=27761716

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Application Number Title Priority Date Filing Date
CA002463595A Abandoned CA2463595A1 (fr) 2002-02-20 2003-02-18 Inhibition de l'expression du gene bcl2 induite par interference arn au moyen de petits acides nucleiques interferents (sina)

Country Status (5)

Country Link
EP (1) EP1442143A4 (fr)
JP (1) JP2005517452A (fr)
AU (1) AU2003213119A1 (fr)
CA (1) CA2463595A1 (fr)
WO (1) WO2003070969A2 (fr)

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