CA2461631A1 - Methodes et compositions de prevention, de diagnostic, et de traitement du cancer au moyen de molecules bispecifiques - Google Patents
Methodes et compositions de prevention, de diagnostic, et de traitement du cancer au moyen de molecules bispecifiques Download PDFInfo
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- CA2461631A1 CA2461631A1 CA002461631A CA2461631A CA2461631A1 CA 2461631 A1 CA2461631 A1 CA 2461631A1 CA 002461631 A CA002461631 A CA 002461631A CA 2461631 A CA2461631 A CA 2461631A CA 2461631 A1 CA2461631 A1 CA 2461631A1
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
L'invention se rapporte à des molécules bispécifiques présentant une première partie de reconnaissance de l'antigène qui fixe un récepteur de type C3b (connu comme récepteur de complément 1 (CR1) ou CD35 chez les primates), et une seconde partie de reconnaissance de l'antigène qui fixe un antigène associé à une tumeur et présent dans la circulation d'un mammifère. L'invention se rapporte également à des méthodes d'utilisation des molécules bispécifiques pour éliminer de la circulation d'un mammifère les antigènes associés à une tumeur libérés. En outre, l'invention se rapporte à des méthodes d'utilisation de molécules bispécifiques pour le diagnostic et le traitement du cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32573201P | 2001-09-28 | 2001-09-28 | |
| US60/325,732 | 2001-09-28 | ||
| PCT/US2002/031020 WO2003026490A2 (fr) | 2001-09-28 | 2002-09-27 | Methodes et compositions de prevention, de diagnostic, et de traitement du cancer au moyen de molecules bispecifiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2461631A1 true CA2461631A1 (fr) | 2003-04-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002461631A Abandoned CA2461631A1 (fr) | 2001-09-28 | 2002-09-27 | Methodes et compositions de prevention, de diagnostic, et de traitement du cancer au moyen de molecules bispecifiques |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1487487A2 (fr) |
| JP (1) | JP2005510470A (fr) |
| CA (1) | CA2461631A1 (fr) |
| WO (1) | WO2003026490A2 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20060147457A1 (en) * | 2002-05-13 | 2006-07-06 | Porter James P | Purified composition of bispecific molecules and methods of production |
| CA2543830A1 (fr) * | 2003-10-27 | 2005-05-19 | Monogram Biosciences, Inc. | Detection d'anticorps anti-therapeutique humain |
| AU2005302312A1 (en) * | 2004-10-29 | 2006-05-11 | Elusys Therapeutics, Inc. | Use of CR1-binding molecules in clearance and induction of immune responses |
| EP1846558A2 (fr) * | 2005-02-09 | 2007-10-24 | Genentech, Inc. | Inhibition d'excretion de her2 au moyen d'antagonistes de metalloprotease matricielle |
| PT1912675E (pt) | 2005-07-25 | 2014-05-09 | Emergent Product Dev Seattle | Moléculas de ligaçao especificas para cd37 e especificas para cd20 |
| MX380352B (es) | 2006-06-12 | 2025-03-12 | Aptevo Res & Development Llc | Proteinas de union multivalentes monocatenarias con funcion efectora. |
| RS51975B (sr) | 2008-04-11 | 2012-02-29 | Emergent Product Development Seattle Llc. | Cd37 imunoterapeutski proizvod i njegova kombinacija sa bifunkcionalnim hemoterapeutskim sredstvom |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| PT3221359T (pt) | 2014-11-17 | 2020-06-23 | Regeneron Pharma | Métodos para o tratamento de tumores usando anticorpos biespecíficos cd3xcd20 |
| JP6773679B2 (ja) | 2015-03-30 | 2020-10-21 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｆｃガンマ受容体に対する結合が低下した重鎖定常領域 |
| BR112018005573A2 (pt) | 2015-09-21 | 2019-01-22 | Aptevo Research And Development Llc | ?polipeptídeos de ligação a cd3? |
| DK3353212T3 (da) * | 2015-09-23 | 2021-12-20 | Regeneron Pharma | Optimerede bispecifikke anti-CD3-antistoffer og anvendelser deraf |
| IL280875B2 (en) | 2018-08-31 | 2024-12-01 | Regeneron Pharma | Dosing strategy that mitigates cytokine release syndrome for cd3/c20 bispecific antibodies |
-
2002
- 2002-09-27 EP EP02778405A patent/EP1487487A2/fr not_active Withdrawn
- 2002-09-27 WO PCT/US2002/031020 patent/WO2003026490A2/fr not_active Ceased
- 2002-09-27 JP JP2003530136A patent/JP2005510470A/ja active Pending
- 2002-09-27 CA CA002461631A patent/CA2461631A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1487487A2 (fr) | 2004-12-22 |
| WO2003026490A2 (fr) | 2003-04-03 |
| JP2005510470A (ja) | 2005-04-21 |
| WO2003026490A3 (fr) | 2004-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20060927 |