CA2337830A1 - Instrument mecanique electro-optique - Google Patents
Instrument mecanique electro-optique Download PDFInfo
- Publication number
- CA2337830A1 CA2337830A1 CA002337830A CA2337830A CA2337830A1 CA 2337830 A1 CA2337830 A1 CA 2337830A1 CA 002337830 A CA002337830 A CA 002337830A CA 2337830 A CA2337830 A CA 2337830A CA 2337830 A1 CA2337830 A1 CA 2337830A1
- Authority
- CA
- Canada
- Prior art keywords
- optical signal
- specimen
- optical
- path
- drive mechanism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000003287 optical effect Effects 0.000 claims abstract description 74
- 238000000018 DNA microarray Methods 0.000 abstract description 8
- 239000000975 dye Substances 0.000 description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 238000002493 microarray Methods 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000001712 DNA sequencing Methods 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002974 pharmacogenomic effect Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0036—Scanning details, e.g. scanning stages
- G02B21/0048—Scanning details, e.g. scanning stages scanning mirrors, e.g. rotating or galvanomirrors, MEMS mirrors
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Microscoopes, Condenser (AREA)
Abstract
L'invention concerne un microscope laser à balayage que l'on peut utiliser pour scanner des biopuces et qui comprend un émetteur, y compris des lasers (12A-C), qui émet un signal optique (14), un miroir diviseur de faisceau (20) comportant une ouverture (22), un réflecteur (36) qui dirige un signal optique (14) sur un échantillon (90), un ensemble détecteur, y compris les détecteurs (42A-C), qui détecte un signal optique (44) réfléchi depuis l'échantillon (90), un premier mécanisme d'entraînement destiné à modifier la position du signal optique (14) sur l'échantillon (90) et un deuxième mécanisme d'entraînement destiné à modifier la position de l'échantillon (90) par rapport au signal optique (14).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9388298P | 1998-07-23 | 1998-07-23 | |
| US60/093,882 | 1998-07-23 | ||
| PCT/US1999/016412 WO2000005739A1 (fr) | 1998-07-23 | 1999-07-20 | Instrument mecanique electro-optique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2337830A1 true CA2337830A1 (fr) | 2000-02-03 |
Family
ID=22241515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002337830A Abandoned CA2337830A1 (fr) | 1998-07-23 | 1999-07-20 | Instrument mecanique electro-optique |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1108262A1 (fr) |
| AU (1) | AU5115399A (fr) |
| CA (1) | CA2337830A1 (fr) |
| WO (1) | WO2000005739A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6899700B2 (en) | 2001-08-29 | 2005-05-31 | Kimberly-Clark Worldwide, Inc. | Therapeutic agent delivery tampon |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5736257A (en) * | 1995-04-25 | 1998-04-07 | Us Navy | Photoactivatable polymers for producing patterned biomolecular assemblies |
-
1999
- 1999-07-20 AU AU51153/99A patent/AU5115399A/en not_active Abandoned
- 1999-07-20 EP EP99935743A patent/EP1108262A1/fr not_active Withdrawn
- 1999-07-20 CA CA002337830A patent/CA2337830A1/fr not_active Abandoned
- 1999-07-20 WO PCT/US1999/016412 patent/WO2000005739A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000005739A1 (fr) | 2000-02-03 |
| AU5115399A (en) | 2000-02-14 |
| EP1108262A1 (fr) | 2001-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |