CA2331370A1 - Compositions a base d'oligomeres proteiniques renfermant la proteine endostatine et procedes d'utilisation - Google Patents
Compositions a base d'oligomeres proteiniques renfermant la proteine endostatine et procedes d'utilisation Download PDFInfo
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- CA2331370A1 CA2331370A1 CA002331370A CA2331370A CA2331370A1 CA 2331370 A1 CA2331370 A1 CA 2331370A1 CA 002331370 A CA002331370 A CA 002331370A CA 2331370 A CA2331370 A CA 2331370A CA 2331370 A1 CA2331370 A1 CA 2331370A1
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- endostatin
- oligomer
- protein
- zinc
- oligomers
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne des compositions à base d'oligomères protéiniques renfermant la protéine endostatine, ainsi que des procédés relatifs à l'utilisation desdites compositions, pour interrompre la formation de tubules et inhiber la tumorigenèse. Ces compositions représentent une nouvelle classe de facteurs de dispersion et comprennent spécifiquement les dimères et les trimères de la protéine endostatine, s'étendant éventuellement à des ions métalliques du type zinc.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8789098P | 1998-06-03 | 1998-06-03 | |
| US60/087,890 | 1998-06-03 | ||
| US9239398P | 1998-07-10 | 1998-07-10 | |
| US60/092,393 | 1998-07-10 | ||
| US9879098P | 1998-09-01 | 1998-09-01 | |
| US60/7098,790 | 1998-09-01 | ||
| PCT/US1999/012278 WO1999062944A2 (fr) | 1998-06-03 | 1999-06-03 | Compositions a base d'oligomeres proteiniques renfermant la proteine endostatine et procedes d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2331370A1 true CA2331370A1 (fr) | 1999-12-09 |
Family
ID=27375776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002331370A Abandoned CA2331370A1 (fr) | 1998-06-03 | 1999-06-03 | Compositions a base d'oligomeres proteiniques renfermant la proteine endostatine et procedes d'utilisation |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2002517186A (fr) |
| KR (1) | KR20010052566A (fr) |
| AU (1) | AU4414099A (fr) |
| CA (1) | CA2331370A1 (fr) |
| WO (1) | WO1999062944A2 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6358735B1 (en) | 1995-06-30 | 2002-03-19 | University Of Kansas Medical Center | Method for inhibiting angiogenesis and tumors with the isolated NC1 α3 chain monomer of type IV collagen |
| US6440729B1 (en) | 1995-06-30 | 2002-08-27 | University Of Kansas Medical Center | Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen |
| ES2590912T3 (es) | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
| PL202057B1 (pl) * | 1998-08-25 | 2009-05-29 | Merck Patent Gmbh | Homodimeryczne białko fuzyjne będące inhibitorem angiogenezy, sposób jego otrzymywania oraz cząsteczka DNA i wektor ekspresyjny zawierający to DNA |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| AU778611B2 (en) | 1999-08-09 | 2004-12-16 | Merck Patent Gmbh | Multiple cytokine-antibody complexes |
| CA2391080A1 (fr) | 1999-11-12 | 2001-05-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Formes d'erythropoietine dotees de proprietes ameliorees |
| ATE336514T1 (de) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
| ATE368475T1 (de) | 2000-06-29 | 2007-08-15 | Emd Lexigen Res Ct Corp | Steigerung von durch antikörper-zytokin- fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
| BR0207854A (pt) | 2001-03-07 | 2004-08-24 | Merck Patent Gmbh | Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido |
| WO2002079415A2 (fr) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reduction de l'immunogenicite de proteines de fusion |
| DK1383785T3 (da) | 2001-05-03 | 2011-05-23 | Merck Patent Gmbh | Rekombinant tumorspecifikt antistof og anvendelse deraf |
| PT1454138E (pt) | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
| DK1572748T3 (da) | 2002-12-17 | 2010-08-23 | Merck Patent Gmbh | Humaniseret antistof (H14.18) af muse-14.18-antistof der binder til GD2 og dets fusionsprotein med IL-2 |
| US7524811B2 (en) | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
| JP2007529410A (ja) * | 2003-08-29 | 2007-10-25 | チルドレンズ メディカル センター コーポレーション | 子宮内膜症を治療又は防止するためのペプチド |
| FR2898895B1 (fr) * | 2006-03-23 | 2012-04-06 | Univ Reims Champagne Ardenne | Cyclopeptide a activite anti-cancereuse derive du collagene de type iv |
| BRPI0605212B8 (pt) * | 2006-12-12 | 2021-05-25 | Univ Rio De Janeiro | processo de produção de endostatina dimerizada ou oligomerizada, endostatina dimerizada ou oligomerizada e composição farmacêutica |
| WO2009145489A2 (fr) * | 2008-04-04 | 2009-12-03 | 주식회사 프로셀제약 | Protéine recombinante d'endostatine à cellules perméables |
| EP2561888A1 (fr) * | 2011-08-23 | 2013-02-27 | Deutsches Krebsforschungszentrum | Protéine comprenant NC-1 pour traiter des maladies liées à l'angiogenèse |
| CN105765063B (zh) | 2013-09-30 | 2021-05-07 | 中外制药株式会社 | 应用改变的辅助噬菌体制备抗原结合分子的方法 |
| JP6952685B2 (ja) | 2015-06-05 | 2021-10-20 | アイバイオ・インコーポレイテッドＩｂｉｏ， Ｉｎｃ． | 線維症の治療において使用するためのエンドスタチン断片およびバリアント |
| EP4316502A3 (fr) | 2018-04-17 | 2024-08-07 | Heidelberg Biotech GmbH | Moyens et procédés pour le traitement de maladies liées à l'angiogenèse, à la fibrose et au cancer avec des oligomères de protéines comprenant nc-1-fc |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0857210B1 (fr) * | 1995-10-23 | 2003-09-03 | The Children's Medical Center Corporation | Compositions therapeutiques anti-angiogenese et procedes associes |
-
1999
- 1999-06-03 WO PCT/US1999/012278 patent/WO1999062944A2/fr not_active Ceased
- 1999-06-03 KR KR1020007013734A patent/KR20010052566A/ko not_active Ceased
- 1999-06-03 AU AU44140/99A patent/AU4414099A/en not_active Abandoned
- 1999-06-03 JP JP2000552154A patent/JP2002517186A/ja active Pending
- 1999-06-03 CA CA002331370A patent/CA2331370A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002517186A (ja) | 2002-06-18 |
| AU4414099A (en) | 1999-12-20 |
| WO1999062944A2 (fr) | 1999-12-09 |
| KR20010052566A (ko) | 2001-06-25 |
| WO1999062944A3 (fr) | 2000-04-06 |
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