CA2330027A1 - Technique de preparation et d'administration in vivo d'une composition a base de cellules presentant l'antigene - Google Patents
Technique de preparation et d'administration in vivo d'une composition a base de cellules presentant l'antigene Download PDFInfo
- Publication number
- CA2330027A1 CA2330027A1 CA002330027A CA2330027A CA2330027A1 CA 2330027 A1 CA2330027 A1 CA 2330027A1 CA 002330027 A CA002330027 A CA 002330027A CA 2330027 A CA2330027 A CA 2330027A CA 2330027 A1 CA2330027 A1 CA 2330027A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- antigen
- cell
- patient
- effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Cette invention a trait à une technique permettant d'obtenir une fraction de globule sanguin enrichie en cellules présentant l'antigène. Cette technique consiste à traiter un patient à l'aide d'un agent efficace pour mobiliser des cellules souches, à effectuer un prélèvement sanguin sur ce patient, à soumettre ce prélèvement à une centrifugation par densité sur un milieu à densité définie, à récolter les fractions de cellules enrichies dans des cellules présentant l'antigène précurseur et à cultiver ces cellules récoltées dans des conditions propres à produire des cellules ayant la morphologie, le phénotype et la fonction de cellules dendritiques. L'invention, qui concerne également une méthode d'utilisation de ces cellules présentant l'antigène aux fins d'une thérapie in vivo, porte, en outre, sur des compositions pharmaceutiques renfermant ces cellules présentant l'antigène.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8776498P | 1998-06-02 | 1998-06-02 | |
| US60/087,764 | 1998-06-02 | ||
| PCT/US1999/012142 WO1999063050A2 (fr) | 1998-06-02 | 1999-06-01 | Technique de preparation et d'administration in vivo d'une composition a base de cellules presentant l'antigene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2330027A1 true CA2330027A1 (fr) | 1999-12-09 |
Family
ID=22207115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002330027A Abandoned CA2330027A1 (fr) | 1998-06-02 | 1999-06-01 | Technique de preparation et d'administration in vivo d'une composition a base de cellules presentant l'antigene |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1082411A2 (fr) |
| JP (1) | JP2002517409A (fr) |
| AU (1) | AU4226999A (fr) |
| CA (1) | CA2330027A1 (fr) |
| NZ (1) | NZ508936A (fr) |
| WO (1) | WO1999063050A2 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7402307B2 (en) | 1998-03-31 | 2008-07-22 | Geron Corporation | Method for identifying and killing cancer cells |
| WO1999050392A1 (fr) | 1998-03-31 | 1999-10-07 | Geron Corporation | Techniques et compositions permettant de faire apparaitre une reponse immunitaire a un antigene de telomerase |
| US7030228B1 (en) | 1999-11-15 | 2006-04-18 | Miltenyi Biotec Gmbh | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
| EP4178678A1 (fr) | 2020-07-07 | 2023-05-17 | Cancure, LLC | Anticorps mic et agents de liaison et leurs procédés d'utilisation |
| CN119715070B (zh) * | 2025-02-18 | 2025-10-24 | 南方医科大学珠江医院 | 一种白血病骨髓染色体标本的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4412794A1 (de) * | 1994-04-14 | 1995-12-14 | Univ Ludwigs Albert | Verfahren zur Herstellung von dendritischen Zellen, so erhaltene Zellen und Behälter zur Durchführung dieses Verfahrens |
| JPH10504284A (ja) * | 1994-06-14 | 1998-04-28 | ザ ボード オブ トラスティーズ オブ レランド スタンフォード ジュニア ユニバーシティー | 抗原パルス化樹状細胞によるｉｎ ｖｉｖｏ Ｔ細胞活性化法 |
| US5474687A (en) * | 1994-08-31 | 1995-12-12 | Activated Cell Therapy, Inc. | Methods for enriching CD34+ human hematopoietic progenitor cells |
| US6121044A (en) * | 1995-07-12 | 2000-09-19 | Dendreon Corporation | Potent antigen presenting cell composition |
-
1999
- 1999-06-01 EP EP99926111A patent/EP1082411A2/fr not_active Withdrawn
- 1999-06-01 JP JP2000552246A patent/JP2002517409A/ja not_active Withdrawn
- 1999-06-01 NZ NZ508936A patent/NZ508936A/en unknown
- 1999-06-01 AU AU42269/99A patent/AU4226999A/en not_active Abandoned
- 1999-06-01 CA CA002330027A patent/CA2330027A1/fr not_active Abandoned
- 1999-06-01 WO PCT/US1999/012142 patent/WO1999063050A2/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1082411A2 (fr) | 2001-03-14 |
| AU4226999A (en) | 1999-12-20 |
| WO1999063050A3 (fr) | 2000-01-27 |
| NZ508936A (en) | 2005-01-28 |
| WO1999063050A2 (fr) | 1999-12-09 |
| JP2002517409A (ja) | 2002-06-18 |
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