CA2325050A1 - Nitroreductase nouvelle et usages therapeutiques associes - Google Patents
Nitroreductase nouvelle et usages therapeutiques associes Download PDFInfo
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- CA2325050A1 CA2325050A1 CA002325050A CA2325050A CA2325050A1 CA 2325050 A1 CA2325050 A1 CA 2325050A1 CA 002325050 A CA002325050 A CA 002325050A CA 2325050 A CA2325050 A CA 2325050A CA 2325050 A1 CA2325050 A1 CA 2325050A1
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- Prior art keywords
- nitroreductase
- rdxa
- cells
- pylori
- conjugate according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6815—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Selon la présente invention, le gène responsable de la sensibilité au métronidazole chez H. pylori a été identifié. L'inactivation mutationnelle du gène, qui code pour une NADPH nitroréductase insensible à l'oxygène, appelée ici RdxA (désignée par HP0954 dans la séquence du génome entier) (Tomb et al.,1997), est la cause de Mtz?R¿ naturellement acquis dans H. pylori. Selon une des réalisations, la présente invention concerne un procédé d'utilisation de RdxA et de composés associés, éventuellement conjointement avec des composés de ciblage, destiné à convertir des composés aromatiques nitrés en cytotoxines pour les utiliser dans la destruction sélective ou l'inhibition de croissance de populations de cellules cibles. Selon une autre réalisation, la présente invention concerne un procédé d'utilisation de RdxA et de composés associés destiné à convertir des composés aromatiques nitrés en cytotoxines pour les utiliser dans l'élimination, par sélection, des cellules qui expriment RdxA.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8091798P | 1998-04-06 | 1998-04-06 | |
| US60/080,917 | 1998-04-06 | ||
| US8177898P | 1998-04-14 | 1998-04-14 | |
| US60/081,778 | 1998-04-14 | ||
| PCT/US1999/007546 WO1999051270A1 (fr) | 1998-04-06 | 1999-04-06 | Nitroreductase nouvelle et usages therapeutiques associes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2325050A1 true CA2325050A1 (fr) | 1999-10-14 |
Family
ID=26764132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002325050A Abandoned CA2325050A1 (fr) | 1998-04-06 | 1999-04-06 | Nitroreductase nouvelle et usages therapeutiques associes |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1069911A1 (fr) |
| CA (1) | CA2325050A1 (fr) |
| WO (1) | WO1999051270A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0002261D0 (en) * | 2000-02-02 | 2000-03-22 | Amersham Pharm Biotech Uk Ltd | Fluorescent detection method & reagent |
| US7906106B2 (en) | 2007-06-27 | 2011-03-15 | General Electric Company | In vivo cell trafficking |
| US8021647B2 (en) | 2007-06-29 | 2011-09-20 | General Electric Company | In vivo optical imaging |
| WO2012008860A2 (fr) | 2010-07-16 | 2012-01-19 | Auckland Uniservices Limited | Enzymes nitroréductases bactériennes et procédés associés |
| US20150010474A1 (en) * | 2011-12-23 | 2015-01-08 | Auckland Uniservices Limited | Compounds And Methods For Selective Imaging And/Or Ablation |
| CN109593842B (zh) * | 2018-12-21 | 2021-01-01 | 上海芯超生物科技有限公司 | 一种检测和判定幽门螺旋杆菌耐药性的试剂盒和方法 |
| CN110613687A (zh) * | 2019-10-30 | 2019-12-27 | 北京利普松生物科技有限公司 | 一种复方呋喃西林纳米脂质体及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5633158A (en) * | 1991-10-23 | 1997-05-27 | Cancer Research Campaign Technology Limited | Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form |
| US5387598A (en) * | 1994-04-13 | 1995-02-07 | Rossignol; Jean-Francois | Composition and galenic formulation suitable for combatting affections of the lower abdomen |
| US5945124A (en) * | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
-
1999
- 1999-04-06 WO PCT/US1999/007546 patent/WO1999051270A1/fr not_active Ceased
- 1999-04-06 CA CA002325050A patent/CA2325050A1/fr not_active Abandoned
- 1999-04-06 EP EP99917349A patent/EP1069911A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1069911A1 (fr) | 2001-01-24 |
| WO1999051270A1 (fr) | 1999-10-14 |
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