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CA2321302A1 - Synthese de 2-oxopiperazines sur support solide - Google Patents

Synthese de 2-oxopiperazines sur support solide Download PDF

Info

Publication number
CA2321302A1
CA2321302A1 CA002321302A CA2321302A CA2321302A1 CA 2321302 A1 CA2321302 A1 CA 2321302A1 CA 002321302 A CA002321302 A CA 002321302A CA 2321302 A CA2321302 A CA 2321302A CA 2321302 A1 CA2321302 A1 CA 2321302A1
Authority
CA
Canada
Prior art keywords
alkyl
aryl
resin
hydrogen
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002321302A
Other languages
English (en)
Inventor
Sean Rees Klopfenstein
Adam Golebiowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2321302A1 publication Critical patent/CA2321302A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cette invention se rapporte à des procédés servant à produire de la 2-oxopipérazine et des composés homologues, en utilisant une résine comme support solide, ce procédé consistant: (a) à éliminer le groupe protecteur de l'ester d'acide aminé N-protégé de la résine (le cas échéant), (b) à faire réagir l'ester de résine non protégé résultant avec un aldéhyde .alpha.-aminé N-protégé, (c) à modifier éventuellement l'intermédiaire résultant en substituant une fraction non hydrogène sur le résidu N de l'acide aminé, (d) à éliminer le groupe N-protecteur restant du résidu N de l'aldéhyde aminé, et (e) à effectuer le clivage/cyclisation du produit obtenu de la résine.
CA002321302A 1998-02-27 1999-02-08 Synthese de 2-oxopiperazines sur support solide Abandoned CA2321302A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7613098P 1998-02-27 1998-02-27
US60/076,130 1998-02-27
PCT/US1999/002734 WO1999043662A1 (fr) 1998-02-27 1999-02-08 Synthese de 2-oxopiperazines sur support solide

Publications (1)

Publication Number Publication Date
CA2321302A1 true CA2321302A1 (fr) 1999-09-02

Family

ID=22130102

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002321302A Abandoned CA2321302A1 (fr) 1998-02-27 1999-02-08 Synthese de 2-oxopiperazines sur support solide

Country Status (7)

Country Link
EP (1) EP1056727A1 (fr)
JP (1) JP2002504545A (fr)
AU (1) AU2593999A (fr)
CA (1) CA2321302A1 (fr)
IL (1) IL137918A0 (fr)
NO (1) NO20004278D0 (fr)
WO (1) WO1999043662A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964181B2 (en) * 2006-03-30 2011-06-21 Palatin Technologies, Inc. Amino acid surrogates for peptidic constructs
JP5424867B2 (ja) * 2006-03-30 2014-02-26 パラティン・テクノロジーズ・インコーポレーテッド ペプチド構築物のためのアミノ酸代用物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990112A (en) * 1996-06-18 1999-11-23 Affymax Technologies N.V. Inhibitors of metalloproteases pharmaceutical compositions comprising same and methods of their use
US5811241A (en) * 1995-09-13 1998-09-22 Cortech, Inc. Method for preparing and identifying N-substitued 1,4-piperazines and N-substituted 1,4-piperazinediones

Also Published As

Publication number Publication date
AU2593999A (en) 1999-09-15
WO1999043662A1 (fr) 1999-09-02
JP2002504545A (ja) 2002-02-12
IL137918A0 (en) 2001-10-31
EP1056727A1 (fr) 2000-12-06
NO20004278L (no) 2000-08-25
NO20004278D0 (no) 2000-08-25

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued