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CA2307886A1 - Formulations ameliorees de soins personnels - Google Patents

Formulations ameliorees de soins personnels Download PDF

Info

Publication number
CA2307886A1
CA2307886A1 CA002307886A CA2307886A CA2307886A1 CA 2307886 A1 CA2307886 A1 CA 2307886A1 CA 002307886 A CA002307886 A CA 002307886A CA 2307886 A CA2307886 A CA 2307886A CA 2307886 A1 CA2307886 A1 CA 2307886A1
Authority
CA
Canada
Prior art keywords
lipid
formulation
group
agent
formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002307886A
Other languages
English (en)
Inventor
Elena Luriya
Leonid Luriya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LURIDENT Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2307886A1 publication Critical patent/CA2307886A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0291—Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/553—Phospholipids, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Medical Informatics (AREA)
  • Nutrition Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des formulations de soins et d'hygiène personnels destinées à une application topique sur des surfaces muqueuses. Ces formulations renferment un support lipidique amphiphyle sous forme de composition colloïde pouvant comporter un agrégat micellaire ou des micelles mélangées dispersées dans une phase aqueuse continue ou une émulsion de gouttelettes lipidiques suspendues dans une phase aqueuse continue et un agent actif qui est un agent antimicrobien. Le support lipidique présente une forte adhésivité aux membranes muqueuses telles que les tissus doux de la cavité orale. Le support lipidique présente aussi une capacité de charge élevée pour l'agent actif à véhiculer vers ces tissus. Ces formulations présentent les propriétés souhaitables pour transporter une grande quantité d'agent actif afin de le libérer de manière contrôlée et prolongée au niveau du site souhaité, tel que les surfaces membranaires muqueuses et le tissu enveloppant. L'invention concerne donc une formulation à application orale et topique renfermant un agent antimicrobien et un lipide. L'agent est maintenu par le support à travers une interaction hydrophobe et est libéré du support de manière contrôlée pendant une période prolongée. Le lipide est aussi caractérisé en ce qu'il présente une capacité adhésive à l'égard des surfaces membranaires muqueuses. Le lipide et l'agent sont présents, de préférence, dans un rapport allant d'environ 1:10 à environ 10:1, et de manière encore préférable allant de 1:5 à environ 5:1 et de manière encore préférable allant d'environ 1:3 à environ 3:1 dans la formulation.
CA002307886A 1997-10-31 1998-10-18 Formulations ameliorees de soins personnels Abandoned CA2307886A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL12208497A IL122084A (en) 1997-10-31 1997-10-31 Formulation for personal care with mucoadhesive properties
IL122084 1997-10-31
PCT/IL1998/000504 WO1999022703A1 (fr) 1997-10-31 1998-10-18 Formulations ameliorees de soins personnels

Publications (1)

Publication Number Publication Date
CA2307886A1 true CA2307886A1 (fr) 1999-05-14

Family

ID=11070803

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002307886A Abandoned CA2307886A1 (fr) 1997-10-31 1998-10-18 Formulations ameliorees de soins personnels

Country Status (8)

Country Link
EP (1) EP1027029A4 (fr)
JP (1) JP2001521882A (fr)
KR (1) KR20010031621A (fr)
CN (1) CN1283983A (fr)
AU (1) AU758188B2 (fr)
CA (1) CA2307886A1 (fr)
IL (1) IL122084A (fr)
WO (1) WO1999022703A1 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436369B2 (en) * 1998-12-17 2002-08-20 Wm. Wrigley Jr. Company Anti-plaque emulsions and products containing same
US6849263B2 (en) 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
US7087215B2 (en) 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
US6451286B1 (en) * 1998-12-21 2002-09-17 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US6375975B1 (en) * 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
DE19919770A1 (de) * 1999-04-30 2000-11-02 Henkel Kgaa Verwendung nanoskaliger antimikrobieller Wirkstoffe in der Mund- und/oder Zahnpflege
WO2001001962A1 (fr) 1999-07-05 2001-01-11 Idea Ag. Procede d'amelioration du transport a travers des barrieres semi-permeables compatibles
DE19931308A1 (de) * 1999-07-07 2001-01-11 Beiersdorf Ag Desodorierende und/oder antitranspirierend wirkende Zubereitungen mit einem Gehalt an Biochinonen
DE60032246T2 (de) * 1999-09-14 2007-06-21 Mucosal Therapeutics Llc, Wellesley Zusammensetzungen, welche tetracycline enthalten, zur behandlung oder verhinderung von mukositis
KR100343125B1 (ko) * 1999-09-14 2002-07-05 임정옥 도포용 리포좀형 혼합국소마취제 및 그 제조방법
EP1829546A1 (fr) * 1999-09-14 2007-09-05 Mucosal Therapeutics LLC Formulations pour traiter ou prévenir la mucosite
US6946118B1 (en) 1999-09-14 2005-09-20 Orapharma, Inc. Formulations for treating or preventing mucositis
JP2003026567A (ja) * 2001-05-10 2003-01-29 Kanegafuchi Chem Ind Co Ltd 補酵素ｑを有効成分とする粘膜投与用組成物
EP1388340B1 (fr) * 2001-05-10 2010-09-08 Kaneka Corporation Composition pour administration transmucosale contenant une coenzyme q en tant qu'ingredient actif
US8246969B2 (en) 2001-11-16 2012-08-21 Skinmedica, Inc. Compositions containing aromatic aldehydes and their use in treatments
US7473432B2 (en) 2002-10-11 2009-01-06 Idea Ag NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery
US9498454B2 (en) 2003-02-24 2016-11-22 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US9358296B2 (en) 2003-02-24 2016-06-07 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US8992974B2 (en) * 2003-02-24 2015-03-31 Pharmaceuticals Productions, Inc. Transmucosal drug delivery system
US10172810B2 (en) 2003-02-24 2019-01-08 Pharmaceutical Productions, Inc. Transmucosal ketamine delivery composition
US9254294B2 (en) 2003-02-24 2016-02-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
US8802116B2 (en) 2003-02-27 2014-08-12 Novasel Australia Pty. Ltd. Poloxamer emulsion preparations
EP1641427A1 (fr) * 2003-07-03 2006-04-05 Betafarma S.p.A. Bain de bouche antibacterien
US20050058673A1 (en) 2003-09-09 2005-03-17 3M Innovative Properties Company Antimicrobial compositions and methods
FR2861297B1 (fr) * 2003-10-23 2009-04-24 Oreal Emulsion h/e cosmetique ou dermatologique de ph stable
US9028852B2 (en) 2004-09-07 2015-05-12 3M Innovative Properties Company Cationic antiseptic compositions and methods of use
US8198326B2 (en) * 2004-09-07 2012-06-12 3M Innovative Properties Company Phenolic antiseptic compositions and methods of use
JP5642929B2 (ja) 2005-03-10 2014-12-17 スリーエム イノベイティブ プロパティズ カンパニー 微小生体汚染の低減方法
MX2007010908A (es) 2005-03-10 2007-12-05 3M Innovative Properties Co Composiciones antimicrobianas que comprenden esteres de acidos hidroxicarboxilicos.
JP4879539B2 (ja) * 2005-09-26 2012-02-22 株式会社ジーシー 口腔湿潤用組成物
EA200800979A1 (ru) * 2005-11-30 2008-10-30 Дженерекс Фармасьютикалз Инк. Перорально абсорбируемая фармацевтическая композиция и способ введения
ES2304103B1 (es) * 2007-02-22 2009-08-07 Biocosmetics S.L. Composicion para tratamiento de la xerostomia o boca seca.
HU227970B1 (en) 2007-07-10 2012-07-30 Egis Gyogyszergyar Nyrt Pharmaceutical compositions containing silicones of high volatility
CN107019686A (zh) 2007-12-31 2017-08-08 3M创新有限公司 抗微生物组合物
ES2335636B1 (es) * 2008-02-29 2011-05-11 Lipotec, S.A. Composicion cosmetica o dermofarmaceutica de micelas mixtas.
JP5771143B2 (ja) * 2008-07-09 2015-08-26 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ ネブラスカ 硬組織に標的化された化学物質送達用の機能的ミセル
DE102010013081A1 (de) * 2010-03-26 2011-09-29 B. Braun Melsungen Ag Antimikrobielle Öl in Wasser Emulsion
FR2958851B1 (fr) * 2010-04-16 2012-06-29 Xeda International Nouvelles formulations d'ingredient(s) actif(s) d'origine vegetale ou leurs analogues synthetiques ou d'extrait(s) d'origine vegetale les contenant, et de lecithine
DE102010023949A1 (de) * 2010-06-16 2011-12-22 F. Holzer Gmbh In-situ Lecithin-Mikroemulsionsgel-Formulierung
CN101926757B (zh) * 2010-09-01 2013-01-02 北京大学 一种难溶性药物的液体组合物及其制备方法
SG10202009963PA (en) 2011-01-07 2020-11-27 Allergan Inc Melanin modification compositions and methods of use
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
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PL3316856T3 (pl) 2015-06-30 2021-10-25 Sequessome Technology Holdings Limited Zmieszane formulacje
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FR2687314A1 (fr) * 1992-02-18 1993-08-20 Oreal Dispersion de vesicules lipidiques, composition cosmetique et/ou pharmaceutique la contenant et procede de preparation de ladite dispersion.
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
FR2714602B1 (fr) * 1993-12-30 1996-02-09 Oreal Composition antiacnéique pour le traitement simultané des couches superficielles et profondes de la peau, son utilisation.

Also Published As

Publication number Publication date
KR20010031621A (ko) 2001-04-16
AU758188B2 (en) 2003-03-20
AU9558798A (en) 1999-05-24
EP1027029A4 (fr) 2005-09-07
WO1999022703A1 (fr) 1999-05-14
IL122084A0 (en) 1998-03-10
JP2001521882A (ja) 2001-11-13
CN1283983A (zh) 2001-02-14
IL122084A (en) 1999-09-22
EP1027029A1 (fr) 2000-08-16

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued