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CA2306960A1 - Nouveaux derives de benzodiazepine s'utilisant comme agents anti-arythmisants - Google Patents

Nouveaux derives de benzodiazepine s'utilisant comme agents anti-arythmisants Download PDF

Info

Publication number
CA2306960A1
CA2306960A1 CA002306960A CA2306960A CA2306960A1 CA 2306960 A1 CA2306960 A1 CA 2306960A1 CA 002306960 A CA002306960 A CA 002306960A CA 2306960 A CA2306960 A CA 2306960A CA 2306960 A1 CA2306960 A1 CA 2306960A1
Authority
CA
Canada
Prior art keywords
compounds
compound
pharmaceutically acceptable
phenyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002306960A
Other languages
English (en)
Inventor
Nigel J. Liverton
John W. Butcher
David A. Claremon
Harold G. Selnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806686.3A external-priority patent/GB9806686D0/en
Application filed by Individual filed Critical Individual
Publication of CA2306960A1 publication Critical patent/CA2306960A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés de la formule structurale (I) qui sont efficaces dans le traitement de l'arythmie.
CA002306960A 1997-10-17 1998-10-13 Nouveaux derives de benzodiazepine s'utilisant comme agents anti-arythmisants Abandoned CA2306960A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6283397P 1997-10-17 1997-10-17
US60/062,833 1997-10-17
GB9806686.3 1998-03-27
GBGB9806686.3A GB9806686D0 (en) 1998-03-27 1998-03-27 Novel benzodiazepine derivatives as antiarrhythmic agents
PCT/US1998/021597 WO1999020281A1 (fr) 1997-10-17 1998-10-13 Nouveaux derives de benzodiazepine s'utilisant comme agents anti-arythmisants

Publications (1)

Publication Number Publication Date
CA2306960A1 true CA2306960A1 (fr) 1999-04-29

Family

ID=26313382

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002306960A Abandoned CA2306960A1 (fr) 1997-10-17 1998-10-13 Nouveaux derives de benzodiazepine s'utilisant comme agents anti-arythmisants

Country Status (5)

Country Link
EP (1) EP1024811A4 (fr)
JP (1) JP2001520197A (fr)
AU (1) AU1082799A (fr)
CA (1) CA2306960A1 (fr)
WO (1) WO1999020281A1 (fr)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004741A (en) * 1984-06-26 1991-04-02 Merck & Co., Inc. Methods of antagonizing CCK or gastrin with benzodiazepine analogs
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines
US4994258A (en) * 1990-03-05 1991-02-19 Merck & Co., Inc. Gamma emitting, CCK-A antagonists for pancreatic imaging
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5426185A (en) * 1993-11-22 1995-06-20 Merck & Co., Inc. Antiarrhythmic benzodiazepines
EP0776203A4 (fr) * 1994-08-18 1997-12-29 Merck & Co Inc N-2,3-dihydro-1-(2-propyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines
WO1997048686A1 (fr) * 1996-06-21 1997-12-24 Merck & Co., Inc. Nouveaux n-1 alkyl-2-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amides
US5776930A (en) * 1996-06-28 1998-07-07 Merck & Company, Inc. Pharmaceutical preparation
US5817658A (en) * 1997-03-14 1998-10-06 Merck & Company, Inc. Method for treating Meniere's disease

Also Published As

Publication number Publication date
AU1082799A (en) 1999-05-10
WO1999020281A1 (fr) 1999-04-29
EP1024811A4 (fr) 2002-11-13
JP2001520197A (ja) 2001-10-30
EP1024811A1 (fr) 2000-08-09

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Legal Events

Date Code Title Description
FZDE Dead