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CA2303062A1 - Proteases aspartiques humaines - Google Patents

Proteases aspartiques humaines Download PDF

Info

Publication number
CA2303062A1
CA2303062A1 CA002303062A CA2303062A CA2303062A1 CA 2303062 A1 CA2303062 A1 CA 2303062A1 CA 002303062 A CA002303062 A CA 002303062A CA 2303062 A CA2303062 A CA 2303062A CA 2303062 A1 CA2303062 A1 CA 2303062A1
Authority
CA
Canada
Prior art keywords
nhap
polynucleotide
seq
sequence
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002303062A
Other languages
English (en)
Inventor
Hong Xu
Sandra A. Bruno
Laura A. Elsenboss
Michael Fogliano
Victoria L. Cohan
Olga Bandman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2303062A1 publication Critical patent/CA2303062A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention se rapporte à des protéases aspartiques humaines (NHAP) et à des polynucléotides qui identifient et codent ces NHAP. L'invention se rapporte également à des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes et des antagonistes associés. L'invention se rapporte enfin à des méthodes permettant de diagnostiquer, de traiter ou de prévenir les troubles associés à l'expression des NHAP.
CA002303062A 1998-07-16 1999-07-15 Proteases aspartiques humaines Abandoned CA2303062A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11664198A 1998-07-16 1998-07-16
US09/116,641 1998-07-16
PCT/US1999/015988 WO2000004137A1 (fr) 1998-07-16 1999-07-15 Proteases aspartiques humaines

Publications (1)

Publication Number Publication Date
CA2303062A1 true CA2303062A1 (fr) 2000-01-27

Family

ID=22368386

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002303062A Abandoned CA2303062A1 (fr) 1998-07-16 1999-07-15 Proteases aspartiques humaines

Country Status (5)

Country Link
EP (1) EP1030911A1 (fr)
JP (1) JP2002520048A (fr)
AU (1) AU5213199A (fr)
CA (1) CA2303062A1 (fr)
WO (1) WO2000004137A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0897986A3 (fr) * 1997-08-21 2000-07-05 Smithkline Beecham Corporation Protéinase aspartique 5
US7045333B1 (en) 1998-01-16 2006-05-16 Incyte Corporation Human protease molecules
US7160679B1 (en) 1998-05-21 2007-01-09 Diadexus, Inc. Method of diagnosing, monitoring, and staging lung cancer
AU2001267548A1 (en) * 2000-06-26 2002-01-08 Bayer Aktiengesellschaft Regulation of human napsin-like aspartyl protease
EP1500663A1 (fr) * 2000-09-28 2005-01-26 Eli Lilly And Company Protéines secrétées et leurs utilisations.
WO2004009797A2 (fr) * 2002-07-23 2004-01-29 Incyte Corporation Molecules de modification et d'entretien de proteines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9618966D0 (en) * 1996-09-11 1996-10-23 Smithkline Beecham Plc Novel compounds
ATE393227T1 (de) * 1996-11-20 2008-05-15 Oklahoma Med Res Found Klonierung und charakterisierung von napsin, einer aspartat-protease

Also Published As

Publication number Publication date
WO2000004137A9 (fr) 2000-06-08
JP2002520048A (ja) 2002-07-09
AU5213199A (en) 2000-02-07
EP1030911A1 (fr) 2000-08-30
WO2000004137A1 (fr) 2000-01-27

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Legal Events

Date Code Title Description
FZDE Dead