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CA2302036A1 - Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice - Google Patents

Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice Download PDF

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Publication number
CA2302036A1
CA2302036A1 CA002302036A CA2302036A CA2302036A1 CA 2302036 A1 CA2302036 A1 CA 2302036A1 CA 002302036 A CA002302036 A CA 002302036A CA 2302036 A CA2302036 A CA 2302036A CA 2302036 A1 CA2302036 A1 CA 2302036A1
Authority
CA
Canada
Prior art keywords
matrix
mass spectrometry
laser desorption
assisted laser
ionization mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002302036A
Other languages
English (en)
Other versions
CA2302036C (fr
Inventor
Joanna M. Hunter
Hua Lin
Christopher H. Becker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sequenom Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2302036A1 publication Critical patent/CA2302036A1/fr
Application granted granted Critical
Publication of CA2302036C publication Critical patent/CA2302036C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CA002302036A 1997-05-30 1998-05-29 Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice Expired - Fee Related CA2302036C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5093297P 1997-05-30 1997-05-30
US60/050,932 1997-05-30
PCT/US1998/011003 WO1998054751A1 (fr) 1997-05-30 1998-05-29 Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice

Publications (2)

Publication Number Publication Date
CA2302036A1 true CA2302036A1 (fr) 1998-12-03
CA2302036C CA2302036C (fr) 2003-09-02

Family

ID=21968407

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002302036A Expired - Fee Related CA2302036C (fr) 1997-05-30 1998-05-29 Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice

Country Status (4)

Country Link
EP (1) EP0998749A1 (fr)
AU (1) AU7804098A (fr)
CA (1) CA2302036C (fr)
WO (1) WO1998054751A1 (fr)

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* Cited by examiner, † Cited by third party
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US6436635B1 (en) 1992-11-06 2002-08-20 Boston University Solid phase sequencing of double-stranded nucleic acids
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US20030129589A1 (en) 1996-11-06 2003-07-10 Hubert Koster Dna diagnostics based on mass spectrometry
CA2274587A1 (fr) 1996-12-10 1998-06-18 Genetrace Systems Inc. Molecules d'etiquetage massique, non volatiles et liberables
DE10050632A1 (de) * 2000-10-12 2002-04-18 Stiftung Caesar Verfahren zum Nachweis biologischer Moleküle
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US20040121314A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in containers
US20040121311A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in livestock
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
CA2508726A1 (fr) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Procedes d'identification rapide de pathogenes chez l'homme et les betes
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8288523B2 (en) 2003-09-11 2012-10-16 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8163895B2 (en) 2003-12-05 2012-04-24 Ibis Biosciences, Inc. Compositions for use in identification of orthopoxviruses
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
WO2005117270A2 (fr) 2004-05-24 2005-12-08 Isis Pharmaceuticals, Inc. Spectrometrie de masse a filtration ionique selective par seuillage numerique
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US8182992B2 (en) 2005-03-03 2012-05-22 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
EP1904655A2 (fr) 2005-07-21 2008-04-02 Isis Pharmaceuticals, Inc. Procedes pour l'identification et la quantification rapide de variants d'acide nucleique
WO2007118222A2 (fr) 2006-04-06 2007-10-18 Ibis Biosciences, INC Compositions pour l'identification de champignons
CA2663029C (fr) 2006-09-14 2016-07-19 Ibis Biosciences, Inc. Procede d'amplification ciblee de genome entier pour l'identification d'agents pathogenes
US8871471B2 (en) 2007-02-23 2014-10-28 Ibis Biosciences, Inc. Methods for rapid forensic DNA analysis
WO2008151023A2 (fr) 2007-06-01 2008-12-11 Ibis Biosciences, Inc. Procédés et compositions pour l'amplification par déplacement multiple d'acides nucléiques
US8534447B2 (en) 2008-09-16 2013-09-17 Ibis Biosciences, Inc. Microplate handling systems and related computer program products and methods
EP2349549B1 (fr) 2008-09-16 2012-07-18 Ibis Biosciences, Inc. Cartouches de mélange, postes de mélange et kits, et système associé
EP2347254A2 (fr) 2008-09-16 2011-07-27 Ibis Biosciences, Inc. Unités de traitement d'échantillons, systèmes et procédés associés
WO2010080616A1 (fr) 2008-12-19 2010-07-15 Abbott Laboratories Dosage moléculaire pour le diagnostic du paludisme
EP2396803A4 (fr) 2009-02-12 2016-10-26 Ibis Biosciences Inc Ensembles sonde d'ionisation
WO2010104798A1 (fr) 2009-03-08 2010-09-16 Ibis Biosciences, Inc. Procédés de détection d'un bioagent
WO2010114842A1 (fr) 2009-03-30 2010-10-07 Ibis Biosciences, Inc. Systèmes, dispositifs et procédés de détection d'agent biologique
WO2011008971A1 (fr) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Appareil de levage et de montage
WO2011008972A1 (fr) 2009-07-17 2011-01-20 Ibis Biosciences, Inc. Systèmes pour l'identification d'un bioagent
US9416409B2 (en) 2009-07-31 2016-08-16 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
WO2011017656A2 (fr) 2009-08-06 2011-02-10 Ibis Biosciences, Inc. Compositions de base déterminées non massiques pour détection d'acide nucléique
EP3225695A1 (fr) 2009-10-15 2017-10-04 Ibis Biosciences, Inc. Amplification de déplacement multiple
US9758840B2 (en) 2010-03-14 2017-09-12 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
CN116297805A (zh) * 2023-02-28 2023-06-23 厦门金诺花生物技术有限公司 用于maldi-ms的核酸基质溶液及其制备

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920264A (en) * 1989-01-17 1990-04-24 Sri International Method for preparing samples for mass analysis by desorption from a frozen solution
GB2236186B (en) * 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
US5135870A (en) * 1990-06-01 1992-08-04 Arizona Board Of Regents Laser ablation/ionizaton and mass spectrometric analysis of massive polymers
US5700642A (en) * 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers

Also Published As

Publication number Publication date
EP0998749A1 (fr) 2000-05-10
CA2302036C (fr) 2003-09-02
WO1998054751A1 (fr) 1998-12-03
AU7804098A (en) 1998-12-30

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Effective date: 20160530