CA2391987A1 - Systeme et procede de recherche dans un espace combinatoire - Google Patents
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- CA2391987A1 CA2391987A1 CA002391987A CA2391987A CA2391987A1 CA 2391987 A1 CA2391987 A1 CA 2391987A1 CA 002391987 A CA002391987 A CA 002391987A CA 2391987 A CA2391987 A CA 2391987A CA 2391987 A1 CA2391987 A1 CA 2391987A1
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- 229940085991 phosphate ion Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
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- 238000005381 potential energy Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/60—In silico combinatorial chemistry
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/20—Protein or domain folding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Library & Information Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Computing Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Complex Calculations (AREA)
Abstract
L'invention concerne un système et un procédé de recherche dans un espace combinatoire, sans explosion combinatoire. La recherche est effectuée pour diverses combinaisons d'éléments de base, en fonction d'au moins une propriété voulue de combinaison, qui peut être traduite en une mesure quantitative du succès de la recherche. Comme le nombre de variables, et par conséquent le nombre de combinaisons, peut être très grand, on examine de préférence des échantillons de combinaisons. Les éléments de combinaisons qui permettent de maximiser et/ou de favoriser de manière cohérente la mesure quantitative sont ensuite gardés, et les autres éléments sont abandonnés. Le procédé est ensuite répété jusqu'à ce qu'un nombre minimum de combinaisons soit trouvé, celles-ci pouvant être éventuellement évaluées par la suite en fonction d'un paramètre similaire et/ou d'un autre paramètre ou d'une autre caractéristique.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16674499P | 1999-11-22 | 1999-11-22 | |
| US60/166,744 | 1999-11-22 | ||
| US20980600P | 2000-06-07 | 2000-06-07 | |
| US60/209,806 | 2000-06-07 | ||
| PCT/IL2000/000779 WO2001039098A2 (fr) | 1999-11-22 | 2000-11-22 | Systeme et procede de recherche dans un espace combinatoire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2391987A1 true CA2391987A1 (fr) | 2001-05-31 |
Family
ID=26862535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002391987A Abandoned CA2391987A1 (fr) | 1999-11-22 | 2000-11-22 | Systeme et procede de recherche dans un espace combinatoire |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1266337A2 (fr) |
| JP (1) | JP2003524831A (fr) |
| AU (1) | AU780941B2 (fr) |
| CA (1) | CA2391987A1 (fr) |
| WO (1) | WO2001039098A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014026296A1 (fr) * | 2012-08-17 | 2014-02-20 | Zymeworks Inc. | Systèmes et procédés pour l'échantillonnage et l'analyse de la dynamique conformationnelle d'un polymère |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020048772A1 (en) | 2000-02-10 | 2002-04-25 | Dahiyat Bassil I. | Protein design automation for protein libraries |
| US7315786B2 (en) | 1998-10-16 | 2008-01-01 | Xencor | Protein design automation for protein libraries |
| EP1510959A3 (fr) * | 2001-08-10 | 2006-07-26 | Xencor, Inc. | Automatisation de la conception des protéines pour l'élaboration de bibliothèques de protéines |
| US7451917B2 (en) | 2002-01-11 | 2008-11-18 | Hand Held Products, Inc. | Transaction terminal comprising imaging module |
| AU2003252355A1 (en) * | 2002-08-01 | 2004-02-23 | Mochida Pharmaceutical Co., Ltd. | Novel crystalline tryptase and utilization thereof |
| TWI413020B (zh) * | 2008-12-31 | 2013-10-21 | Ind Tech Res Inst | 全域極小值的搜尋方法及系統 |
| JP5691575B2 (ja) | 2011-02-03 | 2015-04-01 | 富士通株式会社 | 故障解析プログラム，故障解析装置および故障解析方法 |
| AU2014212430B2 (en) * | 2013-01-31 | 2019-06-20 | Codexis, Inc. | Methods, systems, and software for identifying bio-molecules with interacting components |
| JP7547799B2 (ja) * | 2020-06-05 | 2024-09-10 | 富士通株式会社 | 構造探索方法、構造探索装置、構造探索用プログラム、及び相互作用ポテンシャル特定方法 |
| CN112649802B (zh) * | 2020-12-01 | 2022-03-22 | 中国人民解放军海军航空大学 | 高分辨传感器弱小多目标检测前跟踪方法 |
| JP2022103481A (ja) | 2020-12-28 | 2022-07-08 | 富士通株式会社 | 環状ペプチドの安定構造探索方法、環状ペプチドの安定構造探索プログラム、及び環状ペプチドの安定構造探索装置 |
| JP2023047726A (ja) * | 2021-09-27 | 2023-04-06 | 富士通株式会社 | 初期構造生成装置、初期構造生成方法及び初期構造生成プログラム |
| WO2025059720A1 (fr) * | 2023-09-21 | 2025-03-27 | Burzin Bhavnagri | Système et procédé de création de composés de plomb et compositions associées |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2286262A1 (fr) * | 1997-04-11 | 1998-10-22 | California Institute Of Technology | Dispositif et methode permettant une mise au point informatisee de proteines |
-
2000
- 2000-11-22 EP EP00977840A patent/EP1266337A2/fr not_active Withdrawn
- 2000-11-22 AU AU15469/01A patent/AU780941B2/en not_active Ceased
- 2000-11-22 JP JP2001540691A patent/JP2003524831A/ja active Pending
- 2000-11-22 WO PCT/IL2000/000779 patent/WO2001039098A2/fr not_active Ceased
- 2000-11-22 CA CA002391987A patent/CA2391987A1/fr not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014026296A1 (fr) * | 2012-08-17 | 2014-02-20 | Zymeworks Inc. | Systèmes et procédés pour l'échantillonnage et l'analyse de la dynamique conformationnelle d'un polymère |
| AU2013302283B2 (en) * | 2012-08-17 | 2015-04-09 | Zymeworks Inc. | Systems and methods for sampling and analysis of polymer conformational dynamics |
| US10482991B2 (en) | 2012-08-17 | 2019-11-19 | Zymeworks Inc. | Systems and methods for sampling and analysis of polymer conformational dynamics |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1546901A (en) | 2001-06-04 |
| JP2003524831A (ja) | 2003-08-19 |
| EP1266337A2 (fr) | 2002-12-18 |
| WO2001039098A2 (fr) | 2001-05-31 |
| WO2001039098A3 (fr) | 2002-09-12 |
| WO2001039098A8 (fr) | 2004-04-29 |
| AU780941B2 (en) | 2005-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20071122 |