CA2390438A1 - Nouvelles proteines 19 secretees par l'homme - Google Patents
Nouvelles proteines 19 secretees par l'homme Download PDFInfo
- Publication number
- CA2390438A1 CA2390438A1 CA002390438A CA2390438A CA2390438A1 CA 2390438 A1 CA2390438 A1 CA 2390438A1 CA 002390438 A CA002390438 A CA 002390438A CA 2390438 A CA2390438 A CA 2390438A CA 2390438 A1 CA2390438 A1 CA 2390438A1
- Authority
- CA
- Canada
- Prior art keywords
- human
- polypeptide
- seq
- sequence
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 321
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 165
- 241000282414 Homo sapiens Species 0.000 title abstract description 562
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 29
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 24
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 24
- 239000013598 vector Substances 0.000 claims abstract description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 406
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 395
- 229920001184 polypeptide Polymers 0.000 claims description 391
- 102000040430 polynucleotide Human genes 0.000 claims description 189
- 108091033319 polynucleotide Proteins 0.000 claims description 189
- 239000002157 polynucleotide Substances 0.000 claims description 188
- 230000014509 gene expression Effects 0.000 claims description 94
- 238000000034 method Methods 0.000 claims description 91
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 85
- 239000012634 fragment Substances 0.000 claims description 83
- 239000002299 complementary DNA Substances 0.000 claims description 76
- 125000003729 nucleotide group Chemical group 0.000 claims description 57
- 239000002773 nucleotide Substances 0.000 claims description 55
- 230000027455 binding Effects 0.000 claims description 39
- 230000000694 effects Effects 0.000 claims description 37
- 150000001413 amino acids Chemical class 0.000 claims description 35
- 239000000047 product Substances 0.000 claims description 35
- 230000004071 biological effect Effects 0.000 claims description 32
- 239000012472 biological sample Substances 0.000 claims description 22
- 238000012217 deletion Methods 0.000 claims description 21
- 230000037430 deletion Effects 0.000 claims description 21
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000035772 mutation Effects 0.000 claims description 5
- 238000004166 bioassay Methods 0.000 claims description 3
- 238000012258 culturing Methods 0.000 claims description 2
- 230000001575 pathological effect Effects 0.000 claims 8
- 239000006228 supernatant Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 181
- 208000035475 disorder Diseases 0.000 abstract description 84
- 201000010099 disease Diseases 0.000 abstract description 68
- 108091026890 Coding region Proteins 0.000 abstract description 6
- 238000002405 diagnostic procedure Methods 0.000 abstract description 4
- 238000002560 therapeutic procedure Methods 0.000 abstract description 3
- 238000010188 recombinant method Methods 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 217
- 210000004027 cell Anatomy 0.000 description 205
- 235000018102 proteins Nutrition 0.000 description 155
- 206010028980 Neoplasm Diseases 0.000 description 112
- 210000001744 T-lymphocyte Anatomy 0.000 description 87
- 230000001605 fetal effect Effects 0.000 description 80
- 235000001014 amino acid Nutrition 0.000 description 60
- 210000004185 liver Anatomy 0.000 description 59
- 201000011510 cancer Diseases 0.000 description 58
- 210000004556 brain Anatomy 0.000 description 50
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 47
- 239000000523 sample Substances 0.000 description 45
- 238000003745 diagnosis Methods 0.000 description 41
- 238000011282 treatment Methods 0.000 description 39
- 210000001124 body fluid Anatomy 0.000 description 38
- 210000001072 colon Anatomy 0.000 description 37
- 229940024606 amino acid Drugs 0.000 description 36
- 210000002826 placenta Anatomy 0.000 description 34
- 210000004072 lung Anatomy 0.000 description 33
- 210000002536 stromal cell Anatomy 0.000 description 31
- 102000005962 receptors Human genes 0.000 description 30
- 108020003175 receptors Proteins 0.000 description 30
- 210000000952 spleen Anatomy 0.000 description 30
- 210000000481 breast Anatomy 0.000 description 29
- 210000002966 serum Anatomy 0.000 description 29
- 210000001672 ovary Anatomy 0.000 description 28
- 210000001550 testis Anatomy 0.000 description 28
- 208000026278 immune system disease Diseases 0.000 description 27
- 208000027418 Wounds and injury Diseases 0.000 description 26
- 239000003446 ligand Substances 0.000 description 26
- 210000001185 bone marrow Anatomy 0.000 description 25
- 210000004443 dendritic cell Anatomy 0.000 description 25
- 230000004069 differentiation Effects 0.000 description 25
- 210000002458 fetal heart Anatomy 0.000 description 25
- 108020004414 DNA Proteins 0.000 description 24
- 206010061535 Ovarian neoplasm Diseases 0.000 description 24
- 239000000427 antigen Substances 0.000 description 24
- 239000002585 base Substances 0.000 description 24
- 239000003153 chemical reaction reagent Substances 0.000 description 24
- 108091007433 antigens Proteins 0.000 description 23
- 102000036639 antigens Human genes 0.000 description 23
- 208000029742 colonic neoplasm Diseases 0.000 description 23
- 238000006467 substitution reaction Methods 0.000 description 23
- 206010009944 Colon cancer Diseases 0.000 description 22
- 239000003795 chemical substances by application Substances 0.000 description 21
- 238000009826 distribution Methods 0.000 description 21
- 210000000130 stem cell Anatomy 0.000 description 21
- 230000000890 antigenic effect Effects 0.000 description 20
- 210000002889 endothelial cell Anatomy 0.000 description 20
- 239000012530 fluid Substances 0.000 description 20
- 210000004369 blood Anatomy 0.000 description 19
- 239000008280 blood Substances 0.000 description 19
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 19
- 230000001900 immune effect Effects 0.000 description 19
- 210000002381 plasma Anatomy 0.000 description 19
- 210000001179 synovial fluid Anatomy 0.000 description 19
- 210000002700 urine Anatomy 0.000 description 19
- 108010076504 Protein Sorting Signals Proteins 0.000 description 18
- 230000035755 proliferation Effects 0.000 description 18
- 210000003606 umbilical vein Anatomy 0.000 description 18
- 108060003951 Immunoglobulin Proteins 0.000 description 17
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 17
- 102000018358 immunoglobulin Human genes 0.000 description 17
- 210000002460 smooth muscle Anatomy 0.000 description 17
- 238000012360 testing method Methods 0.000 description 17
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 16
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 16
- 206010052428 Wound Diseases 0.000 description 16
- 210000000987 immune system Anatomy 0.000 description 16
- 230000002163 immunogen Effects 0.000 description 16
- 206010039073 rheumatoid arthritis Diseases 0.000 description 16
- 206010006187 Breast cancer Diseases 0.000 description 15
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 15
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 15
- 108091028043 Nucleic acid sequence Proteins 0.000 description 15
- 230000035876 healing Effects 0.000 description 15
- 210000000440 neutrophil Anatomy 0.000 description 15
- 230000004913 activation Effects 0.000 description 14
- 238000003556 assay Methods 0.000 description 14
- 210000003719 b-lymphocyte Anatomy 0.000 description 14
- 238000009396 hybridization Methods 0.000 description 14
- 208000032839 leukemia Diseases 0.000 description 14
- 210000000496 pancreas Anatomy 0.000 description 14
- 208000002966 Giant Cell Tumor of Bone Diseases 0.000 description 13
- 208000009956 adenocarcinoma Diseases 0.000 description 13
- 210000000349 chromosome Anatomy 0.000 description 13
- 230000000295 complement effect Effects 0.000 description 13
- 210000005153 frontal cortex Anatomy 0.000 description 13
- 230000003993 interaction Effects 0.000 description 13
- 210000003734 kidney Anatomy 0.000 description 13
- 208000026310 Breast neoplasm Diseases 0.000 description 12
- 108700026244 Open Reading Frames Proteins 0.000 description 12
- 210000001638 cerebellum Anatomy 0.000 description 12
- 210000003754 fetus Anatomy 0.000 description 12
- 210000004013 groin Anatomy 0.000 description 12
- 210000004408 hybridoma Anatomy 0.000 description 12
- 238000009169 immunotherapy Methods 0.000 description 12
- 208000014674 injury Diseases 0.000 description 12
- 210000001161 mammalian embryo Anatomy 0.000 description 12
- 230000008569 process Effects 0.000 description 12
- 210000000813 small intestine Anatomy 0.000 description 12
- 206010020751 Hypersensitivity Diseases 0.000 description 11
- 206010033128 Ovarian cancer Diseases 0.000 description 11
- 235000015872 dietary supplement Nutrition 0.000 description 11
- 230000002357 endometrial effect Effects 0.000 description 11
- 210000002216 heart Anatomy 0.000 description 11
- 230000028993 immune response Effects 0.000 description 11
- 208000015181 infectious disease Diseases 0.000 description 11
- 239000000439 tumor marker Substances 0.000 description 11
- 208000016192 Demyelinating disease Diseases 0.000 description 10
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 10
- 241000699666 Mus <mouse, genus> Species 0.000 description 10
- 125000000539 amino acid group Chemical group 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 10
- 208000006673 asthma Diseases 0.000 description 10
- 230000006399 behavior Effects 0.000 description 10
- 238000003776 cleavage reaction Methods 0.000 description 10
- 230000006378 damage Effects 0.000 description 10
- 230000003511 endothelial effect Effects 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 210000002307 prostate Anatomy 0.000 description 10
- 230000007017 scission Effects 0.000 description 10
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 9
- 201000009030 Carcinoma Diseases 0.000 description 9
- 208000035473 Communicable disease Diseases 0.000 description 9
- 101001063991 Homo sapiens Leptin Proteins 0.000 description 9
- 208000029462 Immunodeficiency disease Diseases 0.000 description 9
- 102000000589 Interleukin-1 Human genes 0.000 description 9
- 108010002352 Interleukin-1 Proteins 0.000 description 9
- 210000004899 c-terminal region Anatomy 0.000 description 9
- 238000001514 detection method Methods 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 239000003814 drug Substances 0.000 description 9
- 208000023965 endometrium neoplasm Diseases 0.000 description 9
- 210000002950 fibroblast Anatomy 0.000 description 9
- 102000049953 human LEP Human genes 0.000 description 9
- 230000005965 immune activity Effects 0.000 description 9
- 230000004048 modification Effects 0.000 description 9
- 238000012986 modification Methods 0.000 description 9
- 201000006417 multiple sclerosis Diseases 0.000 description 9
- 210000000056 organ Anatomy 0.000 description 9
- 210000002741 palatine tonsil Anatomy 0.000 description 9
- 201000000980 schizophrenia Diseases 0.000 description 9
- 208000002874 Acne Vulgaris Diseases 0.000 description 8
- 206010012305 Demyelination Diseases 0.000 description 8
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 8
- 208000009329 Graft vs Host Disease Diseases 0.000 description 8
- 206010018691 Granuloma Diseases 0.000 description 8
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 8
- 206010029379 Neutrophilia Diseases 0.000 description 8
- 201000004681 Psoriasis Diseases 0.000 description 8
- 206010039710 Scleroderma Diseases 0.000 description 8
- 206010040047 Sepsis Diseases 0.000 description 8
- 208000021386 Sjogren Syndrome Diseases 0.000 description 8
- 230000010782 T cell mediated cytotoxicity Effects 0.000 description 8
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 8
- 206010000496 acne Diseases 0.000 description 8
- 230000030741 antigen processing and presentation Effects 0.000 description 8
- 206010003246 arthritis Diseases 0.000 description 8
- 230000001363 autoimmune Effects 0.000 description 8
- 230000005784 autoimmunity Effects 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 8
- 210000000601 blood cell Anatomy 0.000 description 8
- 210000002798 bone marrow cell Anatomy 0.000 description 8
- 210000004700 fetal blood Anatomy 0.000 description 8
- 208000007475 hemolytic anemia Diseases 0.000 description 8
- 230000009610 hypersensitivity Effects 0.000 description 8
- 230000036737 immune function Effects 0.000 description 8
- 230000008105 immune reaction Effects 0.000 description 8
- 238000003018 immunoassay Methods 0.000 description 8
- 230000036512 infertility Effects 0.000 description 8
- 208000000509 infertility Diseases 0.000 description 8
- 231100000535 infertility Toxicity 0.000 description 8
- 210000004379 membrane Anatomy 0.000 description 8
- 239000012528 membrane Substances 0.000 description 8
- 208000004235 neutropenia Diseases 0.000 description 8
- 210000000963 osteoblast Anatomy 0.000 description 8
- 230000024833 regulation of cytokine production Effects 0.000 description 8
- 230000001105 regulatory effect Effects 0.000 description 8
- 210000001525 retina Anatomy 0.000 description 8
- 230000004083 survival effect Effects 0.000 description 8
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 8
- 210000001541 thymus gland Anatomy 0.000 description 8
- 208000037816 tissue injury Diseases 0.000 description 8
- 210000004291 uterus Anatomy 0.000 description 8
- 208000030507 AIDS Diseases 0.000 description 7
- 208000017604 Hodgkin disease Diseases 0.000 description 7
- 208000008383 Wilms tumor Diseases 0.000 description 7
- 230000001640 apoptogenic effect Effects 0.000 description 7
- 239000002158 endotoxin Substances 0.000 description 7
- 210000001723 extracellular space Anatomy 0.000 description 7
- 108020001507 fusion proteins Proteins 0.000 description 7
- 102000037865 fusion proteins Human genes 0.000 description 7
- 210000003246 kidney medulla Anatomy 0.000 description 7
- 230000000670 limiting effect Effects 0.000 description 7
- 210000001577 neostriatum Anatomy 0.000 description 7
- 239000002243 precursor Substances 0.000 description 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 7
- 230000002685 pulmonary effect Effects 0.000 description 7
- 230000001850 reproductive effect Effects 0.000 description 7
- 241000894007 species Species 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 230000014616 translation Effects 0.000 description 7
- 238000013519 translation Methods 0.000 description 7
- 208000003950 B-cell lymphoma Diseases 0.000 description 6
- 206010009900 Colitis ulcerative Diseases 0.000 description 6
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 6
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 206010060862 Prostate cancer Diseases 0.000 description 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 description 6
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 6
- 201000006704 Ulcerative Colitis Diseases 0.000 description 6
- 210000000577 adipose tissue Anatomy 0.000 description 6
- 230000001037 epileptic effect Effects 0.000 description 6
- 238000005755 formation reaction Methods 0.000 description 6
- 206010017758 gastric cancer Diseases 0.000 description 6
- 230000003394 haemopoietic effect Effects 0.000 description 6
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 6
- 230000003054 hormonal effect Effects 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- 201000005202 lung cancer Diseases 0.000 description 6
- 210000004924 lung microvascular endothelial cell Anatomy 0.000 description 6
- 208000020816 lung neoplasm Diseases 0.000 description 6
- 210000001165 lymph node Anatomy 0.000 description 6
- 239000003550 marker Substances 0.000 description 6
- 230000002503 metabolic effect Effects 0.000 description 6
- 210000003463 organelle Anatomy 0.000 description 6
- 230000036961 partial effect Effects 0.000 description 6
- 238000002823 phage display Methods 0.000 description 6
- 230000001817 pituitary effect Effects 0.000 description 6
- 210000005267 prostate cell Anatomy 0.000 description 6
- 201000011549 stomach cancer Diseases 0.000 description 6
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 5
- ZLOIGESWDJYCTF-XVFCMESISA-N 4-thiouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=S)C=C1 ZLOIGESWDJYCTF-XVFCMESISA-N 0.000 description 5
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 5
- 108010088751 Albumins Proteins 0.000 description 5
- 102000009027 Albumins Human genes 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 208000006050 Hemangiopericytoma Diseases 0.000 description 5
- 240000001304 Hippeastrum striatum Species 0.000 description 5
- 208000009164 Islet Cell Adenoma Diseases 0.000 description 5
- 108010052285 Membrane Proteins Proteins 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 206010033963 Parathyroid tumour Diseases 0.000 description 5
- 241000700159 Rattus Species 0.000 description 5
- 208000002495 Uterine Neoplasms Diseases 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 5
- 239000000556 agonist Substances 0.000 description 5
- 230000004075 alteration Effects 0.000 description 5
- 230000000903 blocking effect Effects 0.000 description 5
- 238000004590 computer program Methods 0.000 description 5
- YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 5
- 210000003038 endothelium Anatomy 0.000 description 5
- 229940088598 enzyme Drugs 0.000 description 5
- 229930182833 estradiol Natural products 0.000 description 5
- 229960005309 estradiol Drugs 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 230000005714 functional activity Effects 0.000 description 5
- 230000004927 fusion Effects 0.000 description 5
- 210000003016 hypothalamus Anatomy 0.000 description 5
- 210000002865 immune cell Anatomy 0.000 description 5
- 230000002757 inflammatory effect Effects 0.000 description 5
- 201000002529 islet cell tumor Diseases 0.000 description 5
- 201000005249 lung adenocarcinoma Diseases 0.000 description 5
- 210000002540 macrophage Anatomy 0.000 description 5
- 210000002752 melanocyte Anatomy 0.000 description 5
- 210000001616 monocyte Anatomy 0.000 description 5
- 230000001537 neural effect Effects 0.000 description 5
- 208000022102 pancreatic neuroendocrine neoplasm Diseases 0.000 description 5
- 201000008752 progressive muscular atrophy Diseases 0.000 description 5
- 108020003519 protein disulfide isomerase Proteins 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 238000013456 study Methods 0.000 description 5
- 210000003523 substantia nigra Anatomy 0.000 description 5
- 208000017997 tumor of parathyroid gland Diseases 0.000 description 5
- 206010046766 uterine cancer Diseases 0.000 description 5
- 208000024827 Alzheimer disease Diseases 0.000 description 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 4
- 206010012289 Dementia Diseases 0.000 description 4
- 208000012239 Developmental disease Diseases 0.000 description 4
- 206010023825 Laryngeal cancer Diseases 0.000 description 4
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 4
- 241001529936 Murinae Species 0.000 description 4
- 208000018737 Parkinson disease Diseases 0.000 description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- 102000006010 Protein Disulfide-Isomerase Human genes 0.000 description 4
- 206010039491 Sarcoma Diseases 0.000 description 4
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 4
- -1 allelic variants Proteins 0.000 description 4
- 230000002788 anti-peptide Effects 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 4
- 238000012937 correction Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000028023 exocytosis Effects 0.000 description 4
- 238000002873 global sequence alignment Methods 0.000 description 4
- 210000001320 hippocampus Anatomy 0.000 description 4
- 210000005260 human cell Anatomy 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- 229940072221 immunoglobulins Drugs 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 210000002510 keratinocyte Anatomy 0.000 description 4
- 201000005264 laryngeal carcinoma Diseases 0.000 description 4
- 210000000265 leukocyte Anatomy 0.000 description 4
- 201000005296 lung carcinoma Diseases 0.000 description 4
- 210000004962 mammalian cell Anatomy 0.000 description 4
- 230000000926 neurological effect Effects 0.000 description 4
- 201000010198 papillary carcinoma Diseases 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 230000006337 proteolytic cleavage Effects 0.000 description 4
- 229930002330 retinoic acid Natural products 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 210000004739 secretory vesicle Anatomy 0.000 description 4
- 238000002864 sequence alignment Methods 0.000 description 4
- 238000012163 sequencing technique Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 210000000278 spinal cord Anatomy 0.000 description 4
- 206010042863 synovial sarcoma Diseases 0.000 description 4
- 229960001727 tretinoin Drugs 0.000 description 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 3
- 102100025672 Angiopoietin-related protein 2 Human genes 0.000 description 3
- 101710085851 Angiopoietin-related protein 2 Proteins 0.000 description 3
- 241000972773 Aulopiformes Species 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 3
- 102000016942 Elastin Human genes 0.000 description 3
- 108010014258 Elastin Proteins 0.000 description 3
- 206010021143 Hypoxia Diseases 0.000 description 3
- 108700005091 Immunoglobulin Genes Proteins 0.000 description 3
- 102000004388 Interleukin-4 Human genes 0.000 description 3
- 108090000978 Interleukin-4 Proteins 0.000 description 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 3
- 241000699660 Mus musculus Species 0.000 description 3
- 206010029098 Neoplasm skin Diseases 0.000 description 3
- 241000235347 Schizosaccharomyces pombe Species 0.000 description 3
- 102100038583 Secreted Ly-6/uPAR-related protein 1 Human genes 0.000 description 3
- 101710127389 Secreted Ly-6/uPAR-related protein 1 Proteins 0.000 description 3
- 208000000453 Skin Neoplasms Diseases 0.000 description 3
- 230000021736 acetylation Effects 0.000 description 3
- 238000006640 acetylation reaction Methods 0.000 description 3
- 238000007792 addition Methods 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- 210000004727 amygdala Anatomy 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000009260 cross reactivity Effects 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 210000001951 dura mater Anatomy 0.000 description 3
- 230000004064 dysfunction Effects 0.000 description 3
- 229920002549 elastin Polymers 0.000 description 3
- 210000001671 embryonic stem cell Anatomy 0.000 description 3
- 210000004696 endometrium Anatomy 0.000 description 3
- 210000003979 eosinophil Anatomy 0.000 description 3
- 208000005017 glioblastoma Diseases 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 210000000231 kidney cortex Anatomy 0.000 description 3
- 210000000867 larynx Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 230000009826 neoplastic cell growth Effects 0.000 description 3
- 201000008026 nephroblastoma Diseases 0.000 description 3
- 208000015122 neurodegenerative disease Diseases 0.000 description 3
- 210000002569 neuron Anatomy 0.000 description 3
- 201000008968 osteosarcoma Diseases 0.000 description 3
- 210000003254 palate Anatomy 0.000 description 3
- 201000002528 pancreatic cancer Diseases 0.000 description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 description 3
- 210000004560 pineal gland Anatomy 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 230000004853 protein function Effects 0.000 description 3
- 230000006798 recombination Effects 0.000 description 3
- 238000005215 recombination Methods 0.000 description 3
- 230000000284 resting effect Effects 0.000 description 3
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 3
- 235000019515 salmon Nutrition 0.000 description 3
- 230000003248 secreting effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000004988 splenocyte Anatomy 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- 206010002329 Aneurysm Diseases 0.000 description 2
- 206010003805 Autism Diseases 0.000 description 2
- 208000020706 Autistic disease Diseases 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 208000019838 Blood disease Diseases 0.000 description 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 description 2
- 101150013553 CD40 gene Proteins 0.000 description 2
- 102000014914 Carrier Proteins Human genes 0.000 description 2
- 108010078791 Carrier Proteins Proteins 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102000053602 DNA Human genes 0.000 description 2
- 208000008334 Dermatofibrosarcoma Diseases 0.000 description 2
- 206010057070 Dermatofibrosarcoma protuberans Diseases 0.000 description 2
- 241000255601 Drosophila melanogaster Species 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 201000005231 Epithelioid sarcoma Diseases 0.000 description 2
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 101000958041 Homo sapiens Musculin Proteins 0.000 description 2
- 101001109689 Homo sapiens Nuclear receptor subfamily 4 group A member 3 Proteins 0.000 description 2
- 208000023105 Huntington disease Diseases 0.000 description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 206010026749 Mania Diseases 0.000 description 2
- 201000009906 Meningitis Diseases 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 101100534514 Mus musculus Stmn1 gene Proteins 0.000 description 2
- 101100324954 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) oli gene Proteins 0.000 description 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 description 2
- 206010033864 Paranoia Diseases 0.000 description 2
- 208000027099 Paranoid disease Diseases 0.000 description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 description 2
- 208000028017 Psychotic disease Diseases 0.000 description 2
- 102400001051 Restin Human genes 0.000 description 2
- 230000018199 S phase Effects 0.000 description 2
- 206010058571 Spinal cord infarction Diseases 0.000 description 2
- 208000036982 Spinal cord ischaemia Diseases 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 2
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 2
- 108010092262 T-Cell Antigen Receptors Proteins 0.000 description 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 2
- 206010042971 T-cell lymphoma Diseases 0.000 description 2
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 2
- 208000000728 Thymus Neoplasms Diseases 0.000 description 2
- 208000000323 Tourette Syndrome Diseases 0.000 description 2
- 208000016620 Tourette disease Diseases 0.000 description 2
- 102100040247 Tumor necrosis factor Human genes 0.000 description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 2
- 229910052770 Uranium Inorganic materials 0.000 description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 244000130402 Waltheria indica Species 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 210000001789 adipocyte Anatomy 0.000 description 2
- 210000000593 adipose tissue white Anatomy 0.000 description 2
- 210000004100 adrenal gland Anatomy 0.000 description 2
- 208000024447 adrenal gland neoplasm Diseases 0.000 description 2
- 238000007818 agglutination assay Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 230000009435 amidation Effects 0.000 description 2
- 238000007112 amidation reaction Methods 0.000 description 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 2
- 230000002491 angiogenic effect Effects 0.000 description 2
- 230000005875 antibody response Effects 0.000 description 2
- 210000000709 aorta Anatomy 0.000 description 2
- 230000003542 behavioural effect Effects 0.000 description 2
- 230000008827 biological function Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 208000025434 cerebellar degeneration Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000007385 chemical modification Methods 0.000 description 2
- 230000019771 cognition Effects 0.000 description 2
- 208000012106 cystic neoplasm Diseases 0.000 description 2
- 108010038764 cytoplasmic linker protein 170 Proteins 0.000 description 2
- 210000005220 cytoplasmic tail Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 206010014599 encephalitis Diseases 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 208000021045 exocrine pancreatic carcinoma Diseases 0.000 description 2
- 230000022244 formylation Effects 0.000 description 2
- 238000006170 formylation reaction Methods 0.000 description 2
- 210000001652 frontal lobe Anatomy 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 230000013595 glycosylation Effects 0.000 description 2
- 238000006206 glycosylation reaction Methods 0.000 description 2
- 208000014951 hematologic disease Diseases 0.000 description 2
- 210000000777 hematopoietic system Anatomy 0.000 description 2
- 208000018706 hematopoietic system disease Diseases 0.000 description 2
- 230000002607 hemopoietic effect Effects 0.000 description 2
- 208000008675 hereditary spastic paraplegia Diseases 0.000 description 2
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 2
- 230000013632 homeostatic process Effects 0.000 description 2
- 238000002744 homologous recombination Methods 0.000 description 2
- 230000006801 homologous recombination Effects 0.000 description 2
- 102000046949 human MSC Human genes 0.000 description 2
- 102000047217 human NR4A3 Human genes 0.000 description 2
- 230000003463 hyperproliferative effect Effects 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 208000015446 immunoglobulin a vasculitis Diseases 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 230000004968 inflammatory condition Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 2
- 208000017169 kidney disease Diseases 0.000 description 2
- 230000013016 learning Effects 0.000 description 2
- 201000003723 learning disability Diseases 0.000 description 2
- 125000005647 linker group Chemical group 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000036244 malformation Effects 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 210000000716 merkel cell Anatomy 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 2
- 208000016055 micropapillary serous carcinoma Diseases 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 201000000050 myeloid neoplasm Diseases 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 230000004770 neurodegeneration Effects 0.000 description 2
- 230000004031 neuronal differentiation Effects 0.000 description 2
- 230000006576 neuronal survival Effects 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 208000019906 panic disease Diseases 0.000 description 2
- 201000005163 papillary serous adenocarcinoma Diseases 0.000 description 2
- 208000024641 papillary serous cystadenocarcinoma Diseases 0.000 description 2
- 230000006320 pegylation Effects 0.000 description 2
- 230000008447 perception Effects 0.000 description 2
- 208000027232 peripheral nervous system disease Diseases 0.000 description 2
- 208000033808 peripheral neuropathy Diseases 0.000 description 2
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 2
- 230000026731 phosphorylation Effects 0.000 description 2
- 238000006366 phosphorylation reaction Methods 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 230000001323 posttranslational effect Effects 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000000186 progesterone Substances 0.000 description 2
- 229960003387 progesterone Drugs 0.000 description 2
- 210000004765 promyelocyte Anatomy 0.000 description 2
- 238000002708 random mutagenesis Methods 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 210000004994 reproductive system Anatomy 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 230000007958 sleep Effects 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 208000020431 spinal cord injury Diseases 0.000 description 2
- 210000000225 synapse Anatomy 0.000 description 2
- 230000005062 synaptic transmission Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000010189 synthetic method Methods 0.000 description 2
- 210000000538 tail Anatomy 0.000 description 2
- 208000001608 teratocarcinoma Diseases 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 238000010798 ubiquitination Methods 0.000 description 2
- 230000034512 ubiquitination Effects 0.000 description 2
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 2
- 235000005282 vitamin D3 Nutrition 0.000 description 2
- 239000011647 vitamin D3 Substances 0.000 description 2
- 229940021056 vitamin d3 Drugs 0.000 description 2
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
- ZNAIHAPCDVUWRX-DUCUPYJCSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;4-amino-n-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide;(2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-t Chemical compound CC1=CC(C)=NC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1.N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1.C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O ZNAIHAPCDVUWRX-DUCUPYJCSA-N 0.000 description 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 101150028074 2 gene Proteins 0.000 description 1
- UFBJCMHMOXMLKC-UHFFFAOYSA-N 2,4-dinitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O UFBJCMHMOXMLKC-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- 230000005730 ADP ribosylation Effects 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 102000009840 Angiopoietins Human genes 0.000 description 1
- 108010009906 Angiopoietins Proteins 0.000 description 1
- 101100279855 Arabidopsis thaliana EPFL5 gene Proteins 0.000 description 1
- 101000825903 Arabidopsis thaliana Structural maintenance of chromosomes protein 6B Proteins 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 208000020925 Bipolar disease Diseases 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 101150031358 COLEC10 gene Proteins 0.000 description 1
- 101100291031 Caenorhabditis elegans gly-13 gene Proteins 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 102100024206 Collectin-10 Human genes 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 101150030061 Eloc gene Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- 241000206602 Eukaryota Species 0.000 description 1
- 102100028071 Fibroblast growth factor 7 Human genes 0.000 description 1
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 description 1
- 241000724791 Filamentous phage Species 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 230000010190 G1 phase Effects 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 230000010556 Heparin Binding Activity Effects 0.000 description 1
- 206010019695 Hepatic neoplasm Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101100496086 Homo sapiens CLEC12A gene Proteins 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 description 1
- 101000801195 Homo sapiens TLE family member 5 Proteins 0.000 description 1
- 239000000854 Human Growth Hormone Substances 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 description 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 1
- 229930010555 Inosine Natural products 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102100020873 Interleukin-2 Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000004195 Isomerases Human genes 0.000 description 1
- 108090000769 Isomerases Proteins 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 241000283986 Lepus Species 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 241000408529 Libra Species 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 241000294754 Macroptilium atropurpureum Species 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 101100348047 Mus musculus Ncam2 gene Proteins 0.000 description 1
- 101500006448 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) Endonuclease PI-MboI Proteins 0.000 description 1
- DPUYCSDGMSDKKV-MKBYFEBXSA-N N-Acetyl-L-leucyl-L-isoleucylglycyl-L-valyl-N-methyl-L-prolinamide Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC DPUYCSDGMSDKKV-MKBYFEBXSA-N 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000029726 Neurodevelopmental disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 101100109397 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) arg-8 gene Proteins 0.000 description 1
- 201000010133 Oligodendroglioma Diseases 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 206010033661 Pancytopenia Diseases 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 241000237988 Patellidae Species 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 241001503951 Phoma Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 description 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 102100036352 Protein disulfide-isomerase Human genes 0.000 description 1
- 101150076768 Ptp4a2 gene Proteins 0.000 description 1
- 108091034057 RNA (poly(A)) Proteins 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- 101000702564 Schizosaccharomyces pombe (strain 972 / ATCC 24843) Structural maintenance of chromosomes protein 6 Proteins 0.000 description 1
- 108091058545 Secretory proteins Proteins 0.000 description 1
- 102000040739 Secretory proteins Human genes 0.000 description 1
- 208000020764 Sensation disease Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 1
- 208000026062 Tissue disease Diseases 0.000 description 1
- 108020004566 Transfer RNA Proteins 0.000 description 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 1
- YJQCOFNZVFGCAF-UHFFFAOYSA-N Tunicamycin II Natural products O1C(CC(O)C2C(C(O)C(O2)N2C(NC(=O)C=C2)=O)O)C(O)C(O)C(NC(=O)C=CCCCCCCCCC(C)C)C1OC1OC(CO)C(O)C(O)C1NC(C)=O YJQCOFNZVFGCAF-UHFFFAOYSA-N 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000012867 alanine scanning Methods 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 150000001408 amides Chemical group 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000010516 arginylation Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 208000028683 bipolar I disease Diseases 0.000 description 1
- 210000002459 blastocyst Anatomy 0.000 description 1
- 238000006664 bond formation reaction Methods 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 238000010322 bone marrow transplantation Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 208000025188 carcinoma of pharynx Diseases 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 210000003477 cochlea Anatomy 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 238000012875 competitive assay Methods 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229960000633 dextran sulfate Drugs 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000011124 ex vivo culture Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000037433 frameshift Effects 0.000 description 1
- 230000006251 gamma-carboxylation Effects 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 238000012817 gel-diffusion technique Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 210000002288 golgi apparatus Anatomy 0.000 description 1
- 208000024908 graft versus host disease Diseases 0.000 description 1
- 150000003278 haem Chemical group 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 102000057593 human F8 Human genes 0.000 description 1
- 102000056245 human TLE5 Human genes 0.000 description 1
- 229960000900 human factor viii Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000033444 hydroxylation Effects 0.000 description 1
- 238000005805 hydroxylation reaction Methods 0.000 description 1
- 230000008073 immune recognition Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 238000000760 immunoelectrophoresis Methods 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 238000001114 immunoprecipitation Methods 0.000 description 1
- 238000003017 in situ immunoassay Methods 0.000 description 1
- 230000001965 increasing effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 230000026045 iodination Effects 0.000 description 1
- 238000006192 iodination reaction Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 206010023841 laryngeal neoplasm Diseases 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000001823 molecular biology technique Methods 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- 230000007498 myristoylation Effects 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 230000000626 neurodegenerative effect Effects 0.000 description 1
- 230000007472 neurodevelopment Effects 0.000 description 1
- 230000001123 neurodevelopmental effect Effects 0.000 description 1
- 230000007514 neuronal growth Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000036963 noncompetitive effect Effects 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 210000001706 olfactory mucosa Anatomy 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 108010039177 polyphenylalanine Proteins 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000013823 prenylation Effects 0.000 description 1
- 201000005825 prostate adenocarcinoma Diseases 0.000 description 1
- 238000013197 protein A assay Methods 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 229940043131 pyroglutamate Drugs 0.000 description 1
- 208000037826 rabdomyosarcoma Diseases 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000003660 reticulum Anatomy 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 210000003935 rough endoplasmic reticulum Anatomy 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 208000004548 serous cystadenocarcinoma Diseases 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 208000021550 spleen neoplasm Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000019635 sulfation Effects 0.000 description 1
- 238000005670 sulfation reaction Methods 0.000 description 1
- 201000004595 synovitis Diseases 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 108010030159 thrombin receptor peptide 14 Proteins 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 206010043778 thyroiditis Diseases 0.000 description 1
- 229960000187 tissue plasminogen activator Drugs 0.000 description 1
- 208000025358 tongue carcinoma Diseases 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 108091008578 transmembrane receptors Proteins 0.000 description 1
- 102000027257 transmembrane receptors Human genes 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
- ZHSGGJXRNHWHRS-VIDYELAYSA-N tunicamycin Chemical compound O([C@H]1[C@@H]([C@H]([C@@H](O)[C@@H](CC(O)[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C(NC(=O)C=C2)=O)O)O1)O)NC(=O)/C=C/CC(C)C)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O ZHSGGJXRNHWHRS-VIDYELAYSA-N 0.000 description 1
- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
Abstract
La présente invention concerne de nouvelles protéines sécrétées par l'homme et des acides nucléiques isolés contenant les zones de codage des gènes codant lesdites protéines. En outre, l'invention traite de vecteurs, de cellules hôtes, d'anticorps, et de procédés de recombinaison permettant de produire les protéines sécrétées par l'homme. L'invention a aussi pour objet des procédés diagnostiques et thérapeutiques permettant de diagnostiquer et de traiter les maladies, les troubles et/ou états liés à ces nouvelles protéines sécrétées par l'homme.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16475099P | 1999-11-12 | 1999-11-12 | |
| US60/164,750 | 1999-11-12 | ||
| US21512800P | 2000-06-30 | 2000-06-30 | |
| US60/215,128 | 2000-06-30 | ||
| PCT/US2000/030674 WO2001034800A1 (fr) | 1999-11-12 | 2000-11-08 | Nouvelles proteines 19 secretees par l'homme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2390438A1 true CA2390438A1 (fr) | 2001-05-17 |
Family
ID=26860817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002390438A Abandoned CA2390438A1 (fr) | 1999-11-12 | 2000-11-08 | Nouvelles proteines 19 secretees par l'homme |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1230367A4 (fr) |
| JP (1) | JP2003521242A (fr) |
| AU (1) | AU1916101A (fr) |
| CA (1) | CA2390438A1 (fr) |
| WO (1) | WO2001034800A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030199436A1 (en) * | 1997-10-17 | 2003-10-23 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6391311B1 (en) * | 1998-03-17 | 2002-05-21 | Genentech, Inc. | Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1 |
| US7081521B2 (en) | 1998-05-06 | 2006-07-25 | Genentech, Inc. | Anti-PRO788 antibodies |
| DK1623989T3 (da) * | 1999-03-08 | 2007-10-15 | Genentech Inc | Sammensætninger og fremgangsmåder til diagnosticering af tumorer |
| WO2002026957A2 (fr) * | 2000-09-28 | 2002-04-04 | Bayer Aktiengesellschaft | Regulation de la serine protease humaine |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| EP1314784A1 (fr) * | 2001-11-27 | 2003-05-28 | Bayer Ag | LUSTR2, récepteur couplé à la protéine G et utilisations de celui-ci |
| EP2383278A1 (fr) * | 2002-07-08 | 2011-11-02 | Genentech, Inc. | Méthode pour déterminer B cellulaire maladies |
| JP2010151800A (ja) * | 2008-11-06 | 2010-07-08 | Kumamoto Univ | 生活習慣病及び/又は癌の診断剤 |
| US20110189097A1 (en) * | 2009-11-09 | 2011-08-04 | Dritan Agalliu | Use of WNT inhibitor to inhibit angiogenesis in the CNS |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057435A (en) * | 1997-09-19 | 2000-05-02 | Genentech, Inc. | Tie ligand homologues |
| EP1053245A4 (fr) * | 1998-02-09 | 2002-04-17 | Human Genome Sciences Inc | 45 proteines humaines secretees |
| CA2321105A1 (fr) * | 1998-02-17 | 1999-08-19 | Incyte Pharmaceuticals, Inc. | Proteine de la famille des recepteurs a chaine courte humains du tnf |
| EP1074617A3 (fr) * | 1999-07-29 | 2004-04-21 | Research Association for Biotechnology | Amorces pour la synthèse de cADN de pleine longueur et leur utilisation |
-
2000
- 2000-11-08 WO PCT/US2000/030674 patent/WO2001034800A1/fr not_active Ceased
- 2000-11-08 AU AU19161/01A patent/AU1916101A/en not_active Abandoned
- 2000-11-08 CA CA002390438A patent/CA2390438A1/fr not_active Abandoned
- 2000-11-08 EP EP00982089A patent/EP1230367A4/fr not_active Withdrawn
- 2000-11-08 JP JP2001537496A patent/JP2003521242A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1230367A4 (fr) | 2003-10-22 |
| JP2003521242A (ja) | 2003-07-15 |
| AU1916101A (en) | 2001-06-06 |
| WO2001034800A1 (fr) | 2001-05-17 |
| EP1230367A1 (fr) | 2002-08-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20050239099A1 (en) | 27 human secreted proteins | |
| CA2389722A1 (fr) | 15 proteines secretees humaines | |
| US6936691B2 (en) | Secreted protein HCE3C63 | |
| EP1224285A2 (fr) | 27 proteines humaines secretees | |
| WO2001036432A2 (fr) | 18 proteines secretees humaines | |
| US7078186B2 (en) | Apoptosis related polynucleotides, polypeptides, and antibodies | |
| CA2390438A1 (fr) | Nouvelles proteines 19 secretees par l'homme | |
| US20030036646A1 (en) | Uncoupling protein polynucleotides, polypeptides, and antibodies | |
| US20050010042A1 (en) | 26 human secreted proteins | |
| US7247442B1 (en) | Antibodies to HHPEN62 polypeptide | |
| CA2385884A1 (fr) | 26 proteines secretees humaines | |
| CA2389305A1 (fr) | 28 proteines secretees humaines | |
| CA2390421A1 (fr) | 24 proteines humaines secretees | |
| WO2001023402A1 (fr) | 43 proteines secretees humaines | |
| CA2384584A1 (fr) | 38 proteines secretees humaines | |
| WO2001034627A1 (fr) | 28 proteines humaines secretees | |
| EP1230255A1 (fr) | 25 proteines secretes par l'homme | |
| US20060099575A9 (en) | 67 human secreted proteins | |
| EP1556401A2 (fr) | 22 proteines humaines secretees | |
| CA2387754A1 (fr) | 10 proteines humaines secretees | |
| CA2395815A1 (fr) | Acides nucleiques, proteines et anticorps | |
| WO2001034623A1 (fr) | 29 proteines humaines secretees | |
| WO2001023598A1 (fr) | 41 proteines humaines secretees |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |