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CA2383177A1 - Recepteur humain couple a une proteine g - Google Patents

Recepteur humain couple a une proteine g Download PDF

Info

Publication number
CA2383177A1
CA2383177A1 CA002383177A CA2383177A CA2383177A1 CA 2383177 A1 CA2383177 A1 CA 2383177A1 CA 002383177 A CA002383177 A CA 002383177A CA 2383177 A CA2383177 A CA 2383177A CA 2383177 A1 CA2383177 A1 CA 2383177A1
Authority
CA
Canada
Prior art keywords
igs3
polypeptide
seq
nucleotide sequence
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002383177A
Other languages
English (en)
Inventor
Willy Deleersnijder
Guy Nys
Nicole D'heuvaert
Angelique Van Tetering
Jan Bart Sloothaak
Jurjen Frankena
Jakob Venema
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Healthcare Products BV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2383177A1 publication Critical patent/CA2383177A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)

Abstract

La présente invention concerne la famille des récepteurs couplés à la protéine G, IGS3, et les polynucléotides codant ces protéines IGS3. Cette invention concerne également l'inhibition ou l'activation l'action de ces polynucléotides et polypeptides, des vecteurs renfermant ces polynucléotides, une cellule hôte renfermant ce vecteur, ainsi que des animaux transgéniques non humains chez lesquels le gène IGS3 est surexprimé, mal exprimé, sousexprimé, ou supprimé (animaux à gène inactivé). Cette invention concerne par ailleurs un procédé servant à cribler des composés pouvant agir comme antagonistes ou un antagoniste de ladite famille des récepteurs couplés à la protéine G IGS3, et à utiliser ces polypeptides et ces polynucléotides IGS3, et des agonistes ou des antagonistes de la famille des récepteurs IGS3, pour le traitement d'un large éventail de troubles et des essais diagnostics pour les conditions précitées.
CA002383177A 1999-09-16 2000-09-15 Recepteur humain couple a une proteine g Abandoned CA2383177A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NL1013062 1999-09-16
NL1013062 1999-09-16
EP99203014 1999-09-16
EP99203014.8 1999-09-16
PCT/EP2000/009116 WO2001019983A1 (fr) 1999-09-16 2000-09-15 Recepteur humain couple a une proteine g

Publications (1)

Publication Number Publication Date
CA2383177A1 true CA2383177A1 (fr) 2001-03-22

Family

ID=26153370

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002383177A Abandoned CA2383177A1 (fr) 1999-09-16 2000-09-15 Recepteur humain couple a une proteine g

Country Status (8)

Country Link
EP (1) EP1220914A1 (fr)
JP (1) JP2004500039A (fr)
CN (1) CN1379816A (fr)
AU (1) AU7777400A (fr)
CA (1) CA2383177A1 (fr)
HK (1) HK1044567A1 (fr)
IL (1) IL148515A0 (fr)
WO (1) WO2001019983A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5787501A (en) * 1999-12-28 2001-07-09 Pharmacia & Upjohn Company Novel G protein-coupled receptors
AU2001247766A1 (en) * 2000-03-29 2001-10-08 Pe Corporation (Ny) Isolated human g-protein coupled receptors, nucleic acid molecules encoding human gpcr proteins, and uses thereof
US7510845B2 (en) 2000-05-04 2009-03-31 California Institute Of Technology Assay employing G protein-coupled receptor expressed in dorsal root ganglia
US20030092035A1 (en) 2000-05-04 2003-05-15 Anderson David J. Pain signaling molecules
US7691604B1 (en) 2000-05-04 2010-04-06 California Institute Of Technology MRG polypeptides and nucleic acids encoding the same
WO2001098330A2 (fr) * 2000-06-20 2001-12-27 Euroscreen S.A. Lignee cellulaire recombinee exprimant gpcrx11 en tant que recepteur fonctionnel valide par l'angiopeptine et utile dans le criblage d'agonistes et antagonistes
WO2002004641A1 (fr) * 2000-07-07 2002-01-17 Takeda Chemical Industries, Ltd. Nouvelle proteine receptrice couplee a la proteine g et son adn
AU2002317013B2 (en) 2001-06-27 2007-11-01 Janssen Pharmaceutica N.V. EPF receptor assays, compounds and therapeutic compositions
AU2002323179A1 (en) * 2001-08-20 2003-03-03 Bristol-Myers Squibb Company G-protein coupled receptor polynucleotides and methods of use thereof
EP1340979A3 (fr) * 2002-02-27 2004-02-04 Pfizer Limited Récepteur neuropeptidique et son utilisation
CN103172840B (zh) 2005-04-22 2016-03-02 三菱化学株式会社 来自生物质资源的聚酯及其制造方法
US20160333397A1 (en) * 2014-01-27 2016-11-17 Hitachi, Ltd. Method and device for analyzing reaction liquid after nucleic acid amplification reaction, and device for processing reaction liquid after nucleic acid amplification reaction
CA3104041A1 (fr) * 2018-06-22 2019-12-26 Somalogic, Inc. Dosages multiplex proteomiques ameliores

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9223084D0 (en) * 1992-11-04 1992-12-16 Imp Cancer Res Tech Compounds to target cells

Also Published As

Publication number Publication date
EP1220914A1 (fr) 2002-07-10
WO2001019983A1 (fr) 2001-03-22
HK1044567A1 (zh) 2002-10-25
JP2004500039A (ja) 2004-01-08
IL148515A0 (en) 2002-09-12
CN1379816A (zh) 2002-11-13
AU7777400A (en) 2001-04-17

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Legal Events

Date Code Title Description
FZDE Discontinued