CA2377513A1 - Peptides bispirales a hetero-association - Google Patents
Peptides bispirales a hetero-association Download PDFInfo
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- CA2377513A1 CA2377513A1 CA002377513A CA2377513A CA2377513A1 CA 2377513 A1 CA2377513 A1 CA 2377513A1 CA 002377513 A CA002377513 A CA 002377513A CA 2377513 A CA2377513 A CA 2377513A CA 2377513 A1 CA2377513 A1 CA 2377513A1
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- poly
- peptide
- hetero
- associating
- peptides
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000010512 thermal transition Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
L'invention concerne des procédés relatifs à l'identification de peptides bispiralés à hétéro-association et les utilisations de ces peptides pour l'hétérodimérisation de protéines de fusion. L'invention concerne en outre des vecteurs et des cellules hôtes utiles pour l'élaboration des peptides considérés, ainsi que des (poly)peptides/protéines renfermant lesdits peptides.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34409699A | 1999-06-25 | 1999-06-25 | |
| US09/344,096 | 1999-06-25 | ||
| PCT/EP2000/005922 WO2001000814A2 (fr) | 1999-06-25 | 2000-06-26 | Peptides bispirales a hetero-association |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2377513A1 true CA2377513A1 (fr) | 2001-01-04 |
Family
ID=23349034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002377513A Abandoned CA2377513A1 (fr) | 1999-06-25 | 2000-06-26 | Peptides bispirales a hetero-association |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1194539A2 (fr) |
| CA (1) | CA2377513A1 (fr) |
| WO (1) | WO2001000814A2 (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192596B2 (en) | 1996-08-23 | 2007-03-20 | The Health Protection Agency Ipsen Limited | Recombinant toxin fragments |
| US20030035798A1 (en) | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
| JP2003503067A (ja) * | 1999-06-26 | 2003-01-28 | オデュッセイ・ファーマシューティカルズ，インコーポレイテッド | 最適化された蛋白質−蛋白質相互作用のインビボライブラリー対ライブラリー選択 |
| US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| ATE517917T1 (de) | 2005-06-03 | 2011-08-15 | Ares Trading Sa | Herstellung eines rekombinanten il-18-bindenden proteins |
| ES2395969T3 (es) | 2006-03-24 | 2013-02-18 | Merck Patent Gmbh | Dominios de proteínas heterodiméricas genéticamente modificados |
| US7989173B2 (en) | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
| MX2011002250A (es) | 2008-08-25 | 2011-08-17 | Amplimmune Inc | Antagonistas de muerte celular programada-1 y métodos de uso de los mismos. |
| FR2948940B1 (fr) | 2009-08-04 | 2011-07-22 | Servier Lab | Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA2772204A1 (fr) | 2009-08-31 | 2011-03-03 | Amplimmune, Inc. | Methodes et compositions permettant d'inhiber les rejets de greffe |
| CA3079122A1 (fr) | 2010-03-26 | 2011-09-29 | Trustees Of Dartmouth College | Vista, une proteine mediatrice regulatrice des lymphocytes t, agents de liaison a vista et utilisation associee |
| US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
| US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
| WO2012001647A2 (fr) | 2010-06-30 | 2012-01-05 | Compugen Ltd. | Polypeptides et utilisations de ceux-ci comme médicament pour le traitement de la sclérose en plaques, de l'arthrite rhumatoïde et d'autres maladies auto-immunes |
| WO2016030888A1 (fr) | 2014-08-26 | 2016-03-03 | Compugen Ltd. | Polypeptides et leurs utilisations en tant que médicament pour le traitement de troubles auto-immuns |
| US8999335B2 (en) | 2010-09-17 | 2015-04-07 | Compugen Ltd. | Compositions and methods for treatment of drug resistant multiple myeloma |
| US9409987B2 (en) | 2011-04-15 | 2016-08-09 | Compugen Ltd | Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer |
| US9428574B2 (en) | 2011-06-30 | 2016-08-30 | Compugen Ltd. | Polypeptides and uses thereof for treatment of autoimmune disorders and infection |
| US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
| BR112014032276A2 (pt) | 2012-06-22 | 2017-11-28 | King S College London | construtos de vista-ig e o uso de vista-ig para o tratamento de distúrbios autoimunes, alérgicos e inflamatórios |
| EP3578660A1 (fr) | 2012-07-05 | 2019-12-11 | F. Hoffmann-La Roche AG | Système d'expression et de sécrétion |
| EP3552628A1 (fr) | 2012-09-07 | 2019-10-16 | The Trustees Of Dartmouth College | Modulateurs de la vue pour le diagnostic et le traitement du cancer |
| MY170528A (en) | 2013-02-18 | 2019-08-09 | Vegenics Pty Ltd | Vegfr-3 ligand binding molecules and uses thereof |
| US20160146806A1 (en) | 2013-05-17 | 2016-05-26 | Amplimmune, Inc. | Receptors for b7-h4 |
| US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| AU2014372309C1 (en) | 2013-12-24 | 2017-12-14 | Janssen Pharmaceutica Nv | Anti-VISTA antibodies and fragments |
| MX389695B (es) | 2014-06-11 | 2025-03-20 | Kathy A Green | Uso de agonistas y antagonistas vista para suprimir o aumentar la inmunidad humoral. |
| JP2016002009A (ja) * | 2014-06-13 | 2016-01-12 | 国立大学法人名古屋大学 | タグ付抗体 |
| CN107405398A (zh) | 2014-12-05 | 2017-11-28 | 伊穆奈克斯特股份有限公司 | 鉴定vsig8作为推定vista受体及其用以产生vista/vsig8激动剂和拮抗剂的用途 |
| CN107922497B (zh) | 2015-06-24 | 2022-04-12 | 詹森药业有限公司 | 抗vista抗体和片段 |
| DK3322733T3 (da) | 2015-07-13 | 2021-10-18 | Compugen Ltd | Hide1-sammensætninger og fremgangsmåder |
| TWI756204B (zh) | 2016-02-12 | 2022-03-01 | 比利時商楊森製藥公司 | 抗ｖｉｓｔａ抗體及片段、其用途及鑑定其之方法 |
| BR112018071153A2 (pt) | 2016-04-15 | 2019-04-16 | Immunext, Inc. | anticorpos anti-vista humano e uso dos mesmos |
| US11649285B2 (en) | 2016-08-03 | 2023-05-16 | Bio-Techne Corporation | Identification of VSIG3/VISTA as a novel immune checkpoint and use thereof for immunotherapy |
| EP3551667A4 (fr) * | 2016-12-09 | 2020-06-17 | Seattle Genetics, Inc. | Anticorps bivalents masqués par des bobines enroulées |
| US11787857B2 (en) | 2018-02-02 | 2023-10-17 | Bio-Techne Corporation | Compounds that modulate the interaction of VISTA and VSIG3 and methods of making and using |
| MA52571A (fr) * | 2018-05-08 | 2021-03-17 | Amgen Inc | Anticorps bispécifiques ayant des étiquettes appairées à des charges c-terminales clivables |
| JP6744670B2 (ja) * | 2019-03-15 | 2020-08-19 | 国立大学法人東海国立大学機構 | タグ付抗体 |
| WO2022227066A1 (fr) * | 2021-04-30 | 2022-11-03 | 深圳普瑞金生物药业有限公司 | PROCÉDÉ POUR LE CRIBLAGE DE MUTANTS D'HETERODIMÈRES αβ-TCR |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2196496A1 (fr) * | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Epreuve de complementation de fragments de proteines pour la detection d'interactions entre proteines |
-
2000
- 2000-06-26 CA CA002377513A patent/CA2377513A1/fr not_active Abandoned
- 2000-06-26 WO PCT/EP2000/005922 patent/WO2001000814A2/fr not_active Ceased
- 2000-06-26 EP EP00943898A patent/EP1194539A2/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001000814A2 (fr) | 2001-01-04 |
| EP1194539A2 (fr) | 2002-04-10 |
| WO2001000814A3 (fr) | 2001-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20050627 |