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CA2375841A1 - Nouveaux composes de bispidine utiles dans le traitement des arythmies cardiaques - Google Patents

Nouveaux composes de bispidine utiles dans le traitement des arythmies cardiaques Download PDF

Info

Publication number
CA2375841A1
CA2375841A1 CA002375841A CA2375841A CA2375841A1 CA 2375841 A1 CA2375841 A1 CA 2375841A1 CA 002375841 A CA002375841 A CA 002375841A CA 2375841 A CA2375841 A CA 2375841A CA 2375841 A1 CA2375841 A1 CA 2375841A1
Authority
CA
Canada
Prior art keywords
formula
compound
alkyl
compounds
diazabicyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002375841A
Other languages
English (en)
Inventor
Eva-Lotte Lindstedt Alstermark
Annika Bjore
Magnus Bjorsne
Goran Nilsson
Gert Strandlund
Ylva Ortengren
Magnus Polla
Kjell Andersson
Christer Alstermark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2375841A1 publication Critical patent/CA2375841A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

On décrit des composés de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?41¿, R?42¿, R?43¿, R?44¿, R?45¿, R?46¿, A et B sont tels que définis dans le descriptif. Ces composés sont utiles pour la prophylaxie et le traitement des arythmies, plus particulièrement des arythmies atriale et ventriculaire.
CA002375841A 1999-06-16 2000-06-15 Nouveaux composes de bispidine utiles dans le traitement des arythmies cardiaques Abandoned CA2375841A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9902268A SE9902268D0 (sv) 1999-06-16 1999-06-16 Pharmaceutically active compounds
SE9902268-3 1999-06-16
PCT/SE2000/001254 WO2000077000A1 (fr) 1999-06-16 2000-06-15 Nouveaux composes de bispidine utiles dans le traitement des arythmies cardiaques

Publications (1)

Publication Number Publication Date
CA2375841A1 true CA2375841A1 (fr) 2000-12-21

Family

ID=20416100

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002375841A Abandoned CA2375841A1 (fr) 1999-06-16 2000-06-15 Nouveaux composes de bispidine utiles dans le traitement des arythmies cardiaques

Country Status (24)

Country Link
EP (1) EP1192157A1 (fr)
JP (1) JP2003502329A (fr)
KR (1) KR20020010713A (fr)
CN (1) CN1144805C (fr)
AR (1) AR024577A1 (fr)
AU (1) AU761576B2 (fr)
BR (1) BR0011660A (fr)
CA (1) CA2375841A1 (fr)
CZ (1) CZ20014495A3 (fr)
EE (1) EE200100675A (fr)
HK (1) HK1045520A1 (fr)
HU (1) HUP0203959A3 (fr)
IL (1) IL146754A0 (fr)
IS (1) IS6201A (fr)
MX (1) MXPA01012919A (fr)
NO (1) NO20016117L (fr)
NZ (1) NZ516013A (fr)
PL (1) PL354032A1 (fr)
RU (1) RU2250903C2 (fr)
SE (1) SE9902268D0 (fr)
SK (1) SK18272001A3 (fr)
TR (1) TR200103663T2 (fr)
WO (1) WO2000077000A1 (fr)
ZA (1) ZA200109796B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR030302A1 (es) * 2000-07-07 2003-08-20 Astrazeneca Ab Compuestos de bispidina, formulacion farmaceutica, uso para la fabricacion de medicamentos, proceso para la preparacion de estos compuestos y compuestos intermediarios
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
TWI499418B (zh) * 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl 異喹啉－１（２ｈ）－酮衍生物
US9169198B2 (en) * 2011-07-08 2015-10-27 Bayer Intellectual Property Gmbh Method for the production of 2-amino-5-cyano-N,3-dimethylbenzamide

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1107541A1 (ru) * 1982-12-03 1995-10-20 Институт Тонкой Органической Химии Им.А.Л.Мнджояна 10-нитро-1,6,8-триазатрицикло [6,3,1,1] тридекан-2,5-дион
PT88381B (pt) * 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
DE3732094A1 (de) * 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
DK588489D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Heterocykliske forbindelser, deres fremstilling og anvendelse
TW263504B (fr) * 1991-10-03 1995-11-21 Pfizer
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
AU6032400A (en) 2001-01-02
IL146754A0 (en) 2002-07-25
CZ20014495A3 (cs) 2002-05-15
CN1144805C (zh) 2004-04-07
KR20020010713A (ko) 2002-02-04
NO20016117D0 (no) 2001-12-14
AR024577A1 (es) 2002-10-16
HK1045520A1 (zh) 2002-11-29
WO2000077000A1 (fr) 2000-12-21
IS6201A (is) 2001-12-14
AU761576B2 (en) 2003-06-05
CN1370167A (zh) 2002-09-18
ZA200109796B (en) 2003-02-28
HUP0203959A3 (en) 2003-04-28
EP1192157A1 (fr) 2002-04-03
SE9902268D0 (sv) 1999-06-16
BR0011660A (pt) 2002-03-26
JP2003502329A (ja) 2003-01-21
RU2250903C2 (ru) 2005-04-27
EE200100675A (et) 2003-02-17
WO2000077000A9 (fr) 2003-06-19
TR200103663T2 (tr) 2002-05-21
NO20016117L (no) 2002-02-15
SK18272001A3 (sk) 2002-12-03
PL354032A1 (en) 2003-12-15
NZ516013A (en) 2003-06-30
HUP0203959A2 (hu) 2003-03-28
MXPA01012919A (es) 2002-07-30

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Legal Events

Date Code Title Description
FZDE Discontinued