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CA2375511A1 - (z)-styryl acetoxyphenyle sulfures comme inhibiteurs de la cyclo-oxygenase - Google Patents

(z)-styryl acetoxyphenyle sulfures comme inhibiteurs de la cyclo-oxygenase Download PDF

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Publication number
CA2375511A1
CA2375511A1 CA002375511A CA2375511A CA2375511A1 CA 2375511 A1 CA2375511 A1 CA 2375511A1 CA 002375511 A CA002375511 A CA 002375511A CA 2375511 A CA2375511 A CA 2375511A CA 2375511 A1 CA2375511 A1 CA 2375511A1
Authority
CA
Canada
Prior art keywords
compound according
pharmaceutically acceptable
formula
hydrogen
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002375511A
Other languages
English (en)
Inventor
E. Premkumar Reddy
M. V. Ramana Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple Univ School of Medicine
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2375511A1 publication Critical patent/CA2375511A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F228/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a bond to sulfur or by a heterocyclic ring containing sulfur
    • C08F228/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a bond to sulfur or by a heterocyclic ring containing sulfur by a bond to sulfur
    • C08F228/04—Thioethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de formule (I) dans laquelle R¿1?, R¿2?, R¿3? et R¿4? sont sélectionnés indépendamment l'un de l'autre dans un groupe comprenant hydrogène, halogène, hydroxyle, C¿1?-C¿8? alkyl, C¿1?-C¿6? alcoxy, nitro, cyano, acétoxy, amino, carboxy, sulfamyle, acylsulfamyle inférieur et trifluorométhyle. Ces composés sont des inhibiteurs de l'activité de la cyclo-oxygénase-2 qui servent à traiter les inflammations et les troubles induits par la cyclo-oxygénase.
CA002375511A 1999-06-16 2000-06-16 (z)-styryl acetoxyphenyle sulfures comme inhibiteurs de la cyclo-oxygenase Abandoned CA2375511A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13944599P 1999-06-16 1999-06-16
US60/139,445 1999-06-16
PCT/US2000/016725 WO2000077169A2 (fr) 1999-06-16 2000-06-16 (z)-styryl acetoxyphenyle sulfures comme inhibiteurs de la cyclo-oxygenase

Publications (1)

Publication Number Publication Date
CA2375511A1 true CA2375511A1 (fr) 2000-12-21

Family

ID=22486692

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002375511A Abandoned CA2375511A1 (fr) 1999-06-16 2000-06-16 (z)-styryl acetoxyphenyle sulfures comme inhibiteurs de la cyclo-oxygenase

Country Status (5)

Country Link
US (1) US6656968B1 (fr)
EP (1) EP1191929A4 (fr)
AU (1) AU778825B2 (fr)
CA (1) CA2375511A1 (fr)
WO (1) WO2000077169A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046599A2 (fr) * 2003-11-14 2005-05-26 Temple University - Of The Commonwealth System Of Higher Education Sulfoxydes alpha,beta-insatures destines a traiter des maladies a evolution chronique
DK1740530T3 (da) 2004-03-16 2017-01-09 Temple Univ - Of The Commonwealth System Of Higher Education Substituerede phenoxy- og phenylthioderivater til behandling af proliferative forstyrrelser
ES2452718T3 (es) * 2005-11-30 2014-04-02 Taimed Biologics, Inc. Profármacos a base de lisina de inhibidores de la aspartil proteasa y procesos para su preparación
WO2014047110A2 (fr) 2012-09-20 2014-03-27 Temple University - Of The Commonwealth System Of Higher Education Dérivés alkyl diaryles substitués, procédés de préparation et d'utilisations
WO2017023912A1 (fr) 2015-08-03 2017-02-09 Temple University - Of The Commonwealth System Of Higher Education 2,4,6-trialcoxystyrylarylsulfones, sulfonamides et carboxamides, et procédés de préparation et d'utilisation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3660395B2 (ja) * 1995-06-22 2005-06-15 大鵬薬品工業株式会社 フェニルスルホン誘導体及びその製造方法
US5973191A (en) * 1996-12-30 1999-10-26 Vanderbilt University Selective inhibitors of prostaglandin endoperoxide synthase-2
EP1027330B1 (fr) 1997-10-03 2004-12-08 Temple University of the Commonwealth System of Higher Education Agents anticancereux au styrylsulfone
US6025353A (en) * 1997-11-19 2000-02-15 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents

Also Published As

Publication number Publication date
AU5620700A (en) 2001-01-02
EP1191929A2 (fr) 2002-04-03
US6656968B1 (en) 2003-12-02
AU778825B2 (en) 2004-12-23
WO2000077169A2 (fr) 2000-12-21
EP1191929A4 (fr) 2005-02-16
WO2000077169A3 (fr) 2001-07-05

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Legal Events

Date Code Title Description
FZDE Discontinued