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CA2373198A1 - Cartridge for conducting a chemical reaction - Google Patents

Cartridge for conducting a chemical reaction Download PDF

Info

Publication number
CA2373198A1
CA2373198A1 CA002373198A CA2373198A CA2373198A1 CA 2373198 A1 CA2373198 A1 CA 2373198A1 CA 002373198 A CA002373198 A CA 002373198A CA 2373198 A CA2373198 A CA 2373198A CA 2373198 A1 CA2373198 A1 CA 2373198A1
Authority
CA
Canada
Prior art keywords
chamber
cartridge
flow path
side walls
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002373198A
Other languages
French (fr)
Other versions
CA2373198C (en
Inventor
Kurt E. Petersen
William A. Mcmillan
Frazad Pourahmadi
Ronald Chang
Douglas B. Dority
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cepheid
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26834561&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2373198(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/469,724 external-priority patent/US6431476B1/en
Application filed by Individual filed Critical Individual
Publication of CA2373198A1 publication Critical patent/CA2373198A1/en
Application granted granted Critical
Publication of CA2373198C publication Critical patent/CA2373198C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Materials For Medical Uses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Optical Measuring Cells (AREA)

Abstract

A cartridge (20) for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel (40) extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel (40) comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber.

Claims (18)

1. A cartridge for conducting a chemical reaction, the cartridge comprising:
a) a body having at least one flow path formed therein;
and b) a reaction vessel extending from the body, the vessel comprising:
i) a rigid frame defining the side walls of a reaction chamber, wherein the frame includes at least one channel connecting the flow path to the chamber; and ii) at least one sheet attached to the rigid frame to form a major wall of the chamber, wherein the major wall is sufficiently flexible to conform to a thermal surface.
2. The cartridge of claim 1, wherein the vessel includes first and second flexible sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber.
3. The cartridge of claim 1, wherein at least two of the side walls are optically transmissive and angularly offset from each other by about 90°.
4. The cartridge of claim 3, wherein at least two additional side walls have retro-reflective faces.
5. The cartridge of claim 1, wherein the ratio of the width of the chamber to the thickness of the chamber is at least 4:1, and wherein the chamber has a thickness in the range of 0.5 to 2 mm.
6. The cartridge of claim 1, wherein the vessel includes at least two separate ports in fluid communication with the reaction chamber, and wherein the body includes at least a first channel in fluid communication with the first port and at least a second channel in fluid communication with the second port.
7. The cartridge of claim 1, wherein the body has formed therein:
i) a sample flow path;
ii) a separation region in the sample flow path for separating a desired analyte from a fluid sample;
and iii) an analyte flow path extending from the separation region, wherein the channel in the vessel connects the analyte flow path to the reaction chamber.
8. The cartridge of claim 7, wherein the separation region in the body comprises:
a) a lysing chamber in the sample flow path for lysing cells or viruses in the sample to release material therefrom; and b) at least one solid support positioned in the lysing chamber for capturing the cells or viruses to be lysed.
9. The cartridge of claim 1, wherein the cartridge is in combination with an instrument having:
a) at least one thermal surface for contacting the major wall of the reaction chamber;
b) means for increasing the pressure in the reaction chamber, wherein the pressure increase in the chamber is sufficient to force the major wall to contact and conform to the thermal surface; and c) at least one thermal element for heating or cooling the surface to induce a temperature change within the chamber.
10. The cartridge of claim 9, wherein the vessel includes first and second flexible sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber, the instrument includes first and second thermal surfaces formed by opposing plates positioned to receive the chamber between them, and the pressure increase in the chamber is sufficient to force the major walls to contact and conform to the inner surfaces of the plates.
11. The cartridge of claim 1, wherein at least two of the side walls of the reaction chamber are optically transmissive and angularly offset from each other, and wherein the cartridge is in combination with an optics system having at least one light source for exciting a reaction mixture in the chamber through a first one of the optically transmissive side walls and having at least one detector for detecting light emitted from the chamber through a second one of the optically transmissive side walls.
12. A cartridge for conducting a chemical reaction, the cartridge comprising:
a) a body having at least one flow path formed therein;
and b) a reaction vessel extending from the body, the vessel comprising:
i) two opposing major walls;
ii) side walls connecting the major walls to each other to define a reaction chamber, wherein at least two of the side walls are optically transmissive and angularly offset from each other; and iii) at least one channel connecting the reaction chamber to the flow path in the body.
13. The cartridge of claim 12, wherein the vessel includes:
a) a rigid frame defining the side walls of the chamber; and b) first and second flexible sheets attached to opposite sides of the rigid frame to form the major walls of the chamber.
14. The cartridge of claim 12, wherein the optically transmissive side walls are angularly offset from each other by about 90°.
15. The cartridge of claim 12, wherein at least two additional side walls of the chamber have retro-reflective faces.
16. The cartridge of claim 12, wherein the ratio of the width of the chamber to the thickness of the chamber is at least 4:1, and wherein the chamber has a thickness in the range of 0.5 to 2 mm.
17. The cartridge of claim 12, wherein the vessel includes at least two separate ports in fluid communication with the reaction chamber, and wherein the body includes at least a first channel in fluid communication with the first port and at least a second channel in fluid communication with the second port.
18. The cartridge of claim 12, wherein the body has:
i) a sample flow path;
ii) a separation region in the sample flow path for separating a desired analyte from a fluid sample;
and iii) an analyte flow path extending from the separation region, wherein the channel in the vessel connects the analyte flow path to the reaction chamber.

The cartridge of claim 18, wherein the separation region comprises:
a) a lysing chamber in the sample flow path for lysing cells or viruses in the sample to release material therefrom; and b) at least one solid support positioned in the lysing chamber for capturing the cells or viruses to be lysed.

The cartridge of claim 12, wherein the cartridge is in combination with an instrument having:
a) opposing plates positioned to receive the chamber of the vessel between them;
b) means for increasing the pressure in the chamber, wherein the pressure increase in the chamber is sufficient to force the major walls to contact and conform to the inner surfaces of the plates; and c) at least one thermal element for heating or cooling the surfaces of the plates to induce a temperature change within the chamber.

The cartridge of claim 12, wherein the cartridge is in combination with an optics system having at least one light source for exciting a reaction mixture in the chamber through a first one of the optically transmissive side walls and having at least one detector for detecting light emitted from the chamber through a second one of the optically transmissive side walls.
CA2373198A 1999-05-28 2000-05-30 Cartridge for conducting a chemical reaction Expired - Lifetime CA2373198C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13670399P 1999-05-28 1999-05-28
US60/136,703 1999-05-28
US09/469,724 US6431476B1 (en) 1999-12-21 1999-12-21 Apparatus and method for rapid ultrasonic disruption of cells or viruses
US09/469,724 1999-12-21
PCT/US2000/014739 WO2000072970A1 (en) 1999-05-28 2000-05-30 Cartridge for conducting a chemical reaction

Publications (2)

Publication Number Publication Date
CA2373198A1 true CA2373198A1 (en) 2000-12-07
CA2373198C CA2373198C (en) 2011-10-11

Family

ID=26834561

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2373198A Expired - Lifetime CA2373198C (en) 1999-05-28 2000-05-30 Cartridge for conducting a chemical reaction

Country Status (9)

Country Link
EP (1) EP1181098B2 (en)
JP (2) JP4495866B2 (en)
AT (1) ATE333938T1 (en)
AU (1) AU781122B2 (en)
CA (1) CA2373198C (en)
DE (1) DE60029582T3 (en)
DK (1) DK1181098T4 (en)
ES (1) ES2272289T5 (en)
WO (1) WO2000072970A1 (en)

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DK1181098T3 (en) 2006-12-27
JP4495866B2 (en) 2010-07-07
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EP1181098B1 (en) 2006-07-26
ES2272289T5 (en) 2011-10-21
DE60029582D1 (en) 2006-09-07
JP2009282041A (en) 2009-12-03
JP2003500674A (en) 2003-01-07
AU781122B2 (en) 2005-05-05
DE60029582T3 (en) 2012-03-08
EP1181098A1 (en) 2002-02-27
WO2000072970A1 (en) 2000-12-07
CA2373198C (en) 2011-10-11
JP4800412B2 (en) 2011-10-26
ATE333938T1 (en) 2006-08-15

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