CA2369820A1 - Acides nucleiques codant pour des polypeptides chimeres cd40/cd40l, leurs procedes de production et leurs utilisations - Google Patents
Acides nucleiques codant pour des polypeptides chimeres cd40/cd40l, leurs procedes de production et leurs utilisations Download PDFInfo
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- CA2369820A1 CA2369820A1 CA002369820A CA2369820A CA2369820A1 CA 2369820 A1 CA2369820 A1 CA 2369820A1 CA 002369820 A CA002369820 A CA 002369820A CA 2369820 A CA2369820 A CA 2369820A CA 2369820 A1 CA2369820 A1 CA 2369820A1
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- cd40l
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Cette invention concerne un acide nucléique codant pour un polypeptide chimère comprenant des fragments d'acide nucléique codant pour: i) un peptide signal mammifère et ce qui en découle; ii) le domaine de liaison et de trimérisation de CD40L et ce qui en découle; iii) un espaceur de 50 à 100 acides aminés et ce qui en découle; iv) les domaines transmembranaires et de transduction de signal de CD40. Cet acide nucléique est utile comme agent de thérapie génique pour le traitement local des tumeurs solides.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99107611A EP1067194A1 (fr) | 1999-04-16 | 1999-04-16 | Vecteurs contenant des gènes codant pour CD40 et/ou CD40L, sous le contrôle du promoteur inductibles à cytokine, qui est un promoteur d'amyloide sérique à phase aigue humaine. Procédés de leur fabrication et leurs utilisations |
| EP99107611.8 | 1999-04-16 | ||
| EP99113967 | 1999-07-17 | ||
| EP99113967.6 | 1999-07-17 | ||
| PCT/EP2000/003318 WO2000063395A1 (fr) | 1999-04-16 | 2000-04-13 | Acides nucleiques codant pour des polypeptides chimeres cd40/cd40l, leurs procedes de production et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2369820A1 true CA2369820A1 (fr) | 2000-10-26 |
Family
ID=26152970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002369820A Abandoned CA2369820A1 (fr) | 1999-04-16 | 2000-04-13 | Acides nucleiques codant pour des polypeptides chimeres cd40/cd40l, leurs procedes de production et leurs utilisations |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1173589A1 (fr) |
| JP (1) | JP2003508016A (fr) |
| AR (1) | AR023482A1 (fr) |
| AU (1) | AU3966200A (fr) |
| CA (1) | CA2369820A1 (fr) |
| IL (1) | IL144952A0 (fr) |
| NO (1) | NO20015003D0 (fr) |
| WO (1) | WO2000063395A1 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002028481A2 (fr) | 2000-10-02 | 2002-04-11 | Chiron Corporation | Methodes therapeutiques pour lutter contre les cellules b malignes |
| WO2002036769A2 (fr) * | 2000-10-31 | 2002-05-10 | F. Hoffmann-La Roche Ag | Acides nucleiques codant des polypeptides chimeriques cd40/cd40l, procedes de production et utilisations de ces acides nucleiques |
| PT1684869E (pt) | 2003-11-04 | 2011-09-16 | Novartis Vaccines & Diagnostic | Métodos de terapêutica para cancros relacionados com células b |
| EP2301575A1 (fr) | 2003-11-04 | 2011-03-30 | Novartis Vaccines and Diagnostics, Inc. | Procédé de thérapie pour tumeurs solides exprimant l'antigène de la surface de cellule CD40 |
| DK1684805T3 (da) | 2003-11-04 | 2010-10-04 | Novartis Vaccines & Diagnostic | Anvendelse af antagonist anti-CD40-monoklonale antistoffer til behandling af multipel myeloma |
| SI1682177T1 (sl) | 2003-11-04 | 2010-12-31 | Novartis Vaccines & Diagnostic | Uporaba antagonističnih anti-CD40 protiteles za zdravljenje kronične limfocitne levkemije |
| RS53073B (sr) | 2003-11-04 | 2014-04-30 | Novartis Vaccines And Diagnostics Inc. | Upotreba antagonističkih anti-cd40 monoklonska antitela |
| JP5421590B2 (ja) | 2005-05-18 | 2014-02-19 | ノバルティス アーゲー | 自己免疫および／または炎症性成分を有する疾患の診断および治療のための方法 |
| GEP20125628B (en) | 2006-04-21 | 2012-09-10 | Novartis Ag | Pharmaceutical compositions containing antagonist anti-cd40 antibody |
| ES2520026T3 (es) | 2006-09-18 | 2014-11-11 | The Board Of Trustees Of The University Of Arkansas | Composiciones y métodos para potenciar respuestas inmunitarias |
| BRPI0818736A2 (pt) | 2007-10-30 | 2017-06-13 | Univ Arkansas | composições e métodos para intensificar imunorrepostas à bactéria flagelada |
| CN101969990B (zh) | 2007-11-01 | 2014-07-09 | 阿肯色大学评议会 | 增强针对艾美球虫属的免疫反应的组合物和方法 |
| JP5568807B2 (ja) * | 2008-06-06 | 2014-08-13 | 静岡県 | プロテオミクス解析を用いたメラノーママーカーの同定 |
| CN102811734B (zh) | 2010-01-21 | 2016-02-10 | 阿肯色大学评议会 | 增强免疫应答的疫苗载体和方法 |
| CN102971008B (zh) | 2010-06-09 | 2015-11-25 | 阿肯色大学评议会 | 降低弯曲菌属感染的疫苗和方法 |
| WO2012075111A1 (fr) | 2010-11-30 | 2012-06-07 | Novartis Ag | Utilisation d'anticorps anti-cd40 en thérapie combinée contre des cancers associés aux cellules b |
| US9603915B2 (en) | 2013-02-14 | 2017-03-28 | The Board of Trustees of the University of Akansas | Compositions and methods of enhancing immune responses to Eimeria or limiting Eimeria infection |
| BR112015023024B1 (pt) | 2013-03-15 | 2022-04-19 | The Board Of Trustees Of The University Of Arkansas | Vetor de vacina e composições farmacêuticas compreendendo o mesmo |
| KR102767638B1 (ko) | 2016-05-03 | 2025-02-20 | 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 | 면역자극 및 항원 폴리펩티드를 포함하는 효모 백신 벡터, 및 그를 이용하는 방법 |
| US11564944B2 (en) | 2016-11-21 | 2023-01-31 | Nant Holdings Ip, Llc | Fractal combination therapy |
| US20200024326A1 (en) * | 2018-06-14 | 2020-01-23 | Nantbio, Inc. | Tnf-type receptor-ligand fusion proteins and methods |
| CN113056479A (zh) * | 2018-10-05 | 2021-06-29 | 南特细胞公司 | 腺病毒疫苗媒介物中的cd40和cd40l结合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5716805A (en) * | 1991-10-25 | 1998-02-10 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
| CA2121798C (fr) * | 1991-10-25 | 2007-07-24 | Richard J. Armitage | Nouvelle cytokine |
| US7070771B1 (en) * | 1996-12-09 | 2006-07-04 | Regents Of The University Of California | Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells |
-
2000
- 2000-04-13 JP JP2000612474A patent/JP2003508016A/ja active Pending
- 2000-04-13 AU AU39662/00A patent/AU3966200A/en not_active Abandoned
- 2000-04-13 IL IL14495200A patent/IL144952A0/xx unknown
- 2000-04-13 EP EP00918873A patent/EP1173589A1/fr not_active Withdrawn
- 2000-04-13 CA CA002369820A patent/CA2369820A1/fr not_active Abandoned
- 2000-04-13 WO PCT/EP2000/003318 patent/WO2000063395A1/fr not_active Ceased
- 2000-04-13 AR ARP000101716A patent/AR023482A1/es unknown
-
2001
- 2001-10-15 NO NO20015003A patent/NO20015003D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR023482A1 (es) | 2002-09-04 |
| NO20015003L (no) | 2001-10-15 |
| EP1173589A1 (fr) | 2002-01-23 |
| NO20015003D0 (no) | 2001-10-15 |
| WO2000063395A1 (fr) | 2000-10-26 |
| JP2003508016A (ja) | 2003-03-04 |
| AU3966200A (en) | 2000-11-02 |
| IL144952A0 (en) | 2002-06-30 |
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| FZDE | Discontinued |