CA2368638A1 - Methode de stimulation de l'angiogenese regulee par peptides pr-39 - Google Patents
Methode de stimulation de l'angiogenese regulee par peptides pr-39 Download PDFInfo
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- CA2368638A1 CA2368638A1 CA002368638A CA2368638A CA2368638A1 CA 2368638 A1 CA2368638 A1 CA 2368638A1 CA 002368638 A CA002368638 A CA 002368638A CA 2368638 A CA2368638 A CA 2368638A CA 2368638 A1 CA2368638 A1 CA 2368638A1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne à la fois une méthode et un moyen de régulation de l'angiogénèse dans des cellules vivantes, des tissus ainsi que des organes in situ. La régulation est exécutée à l'aide d'un peptide PR-39 natif ou d'un de ses homologues de longueur plus courte, afin d'avoir une interaction avec des protéasomes tels que ceux présents dans le cytoplasme de cellules viables. Le résultat de l'interaction du peptide PR-39 avec les protéasomes est une diminution de la dégradation intracellulaire de peptides actifs tels que HIF-1.alpha. et par conséquent une stimulation de l'angiogénèse in situ.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/276,868 | 1999-03-26 | ||
| US09/276,868 US7202217B1 (en) | 1998-10-13 | 1999-03-26 | Method for PR-39 peptide regulated stimulation of angiogenesis |
| PCT/US2000/007050 WO2000057895A1 (fr) | 1999-03-26 | 2000-03-16 | Methode de stimulation de l'angiogenese regulee par peptides pr-39 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2368638A1 true CA2368638A1 (fr) | 2000-10-05 |
Family
ID=23058406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002368638A Abandoned CA2368638A1 (fr) | 1999-03-26 | 2000-03-16 | Methode de stimulation de l'angiogenese regulee par peptides pr-39 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1165111A4 (fr) |
| AU (1) | AU4013200A (fr) |
| CA (1) | CA2368638A1 (fr) |
| WO (1) | WO2000057895A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7147633B2 (en) | 1999-06-02 | 2006-12-12 | Boston Scientific Scimed, Inc. | Method and apparatus for treatment of atrial fibrillation |
| US6676679B1 (en) | 1999-11-05 | 2004-01-13 | Boston Scientific Corporation | Method and apparatus for recurrent demand injury in stimulating angiogenesis |
| US6748258B1 (en) | 1999-11-05 | 2004-06-08 | Scimed Life Systems, Inc. | Method and devices for heart treatment |
| AU2599001A (en) * | 1999-12-29 | 2001-07-09 | Beth Israel Deaconess Medical Center | Method for pr-39 peptide mediated selective inhibition of ikappabalpha degradation |
| US20010034501A1 (en) | 2000-03-23 | 2001-10-25 | Tom Curtis P. | Pressure sensor for therapeutic delivery device and method |
| US7214223B2 (en) | 2000-03-24 | 2007-05-08 | Boston Scientific Scimed, Inc. | Photoatherolytic catheter apparatus and method |
| WO2002000278A2 (fr) | 2000-06-26 | 2002-01-03 | Microheart, Inc. | Procedes et dispositifs pour le traitement de tissus ischemiques |
| EP1313327A1 (fr) | 2001-11-14 | 2003-05-21 | Deutsche Thomson-Brandt Gmbh | Appareil d'enregistrement numérique et procédés d'enregistrement numérique |
| SE0300207D0 (sv) | 2003-01-29 | 2003-01-29 | Karolinska Innovations Ab | New use and composition |
| US8044028B2 (en) | 2004-10-18 | 2011-10-25 | Cognis France S.A.S. | Oligopeptides and their use in cosmetics |
| WO2006119183A2 (fr) * | 2005-05-03 | 2006-11-09 | Trustees Of Dartmouth College | Procede pouvant augmenter la masse et la performance cardiaques |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5654273A (en) * | 1994-09-22 | 1997-08-05 | Children's Medical Center Corporation | Synducin mediated modulation of tissue repair |
| US5830993A (en) * | 1995-04-10 | 1998-11-03 | Kansas State University Research Foundation | Synthetic antimicrobial peptide |
-
2000
- 2000-03-16 CA CA002368638A patent/CA2368638A1/fr not_active Abandoned
- 2000-03-16 WO PCT/US2000/007050 patent/WO2000057895A1/fr not_active Ceased
- 2000-03-16 AU AU40132/00A patent/AU4013200A/en not_active Abandoned
- 2000-03-16 EP EP00919442A patent/EP1165111A4/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU4013200A (en) | 2000-10-16 |
| EP1165111A1 (fr) | 2002-01-02 |
| WO2000057895A1 (fr) | 2000-10-05 |
| EP1165111A4 (fr) | 2004-11-03 |
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