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CA2364908A1 - Derives de pyrazol-3-one - Google Patents

Derives de pyrazol-3-one Download PDF

Info

Publication number
CA2364908A1
CA2364908A1 CA002364908A CA2364908A CA2364908A1 CA 2364908 A1 CA2364908 A1 CA 2364908A1 CA 002364908 A CA002364908 A CA 002364908A CA 2364908 A CA2364908 A CA 2364908A CA 2364908 A1 CA2364908 A1 CA 2364908A1
Authority
CA
Canada
Prior art keywords
formula
compounds
ylmethyl
group
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002364908A
Other languages
English (en)
Inventor
Dieter Dorsch
Horst Juraszyk
Werner Mederski
Christos Tsaklakidis
Hanns Wurziger
Sabine Bernotat-Danielowski
Guido Melzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2364908A1 publication Critical patent/CA2364908A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés de la formule (I) où R?1¿, R?2¿, R?3¿, R?4¿, X et Y, ayant la signification donnée dans la revendication 1, sont des inhibiteurs du facteur de coagulation Xa. Ils peuvent être utilisés pour prévenir et/ou traiter les maladies thromboemboliques.
CA002364908A 1999-03-03 2000-02-29 Derives de pyrazol-3-one Abandoned CA2364908A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19909237.0 1999-03-03
DE19909237A DE19909237A1 (de) 1999-03-03 1999-03-03 Pyrazol-3-on-derivate
PCT/EP2000/001695 WO2000051989A1 (fr) 1999-03-03 2000-02-29 Derives de pyrazol-3-one utilises comme inhibiteurs du facteur xa

Publications (1)

Publication Number Publication Date
CA2364908A1 true CA2364908A1 (fr) 2000-09-08

Family

ID=7899522

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002364908A Abandoned CA2364908A1 (fr) 1999-03-03 2000-02-29 Derives de pyrazol-3-one

Country Status (17)

Country Link
EP (1) EP1157010A1 (fr)
JP (1) JP2002538143A (fr)
KR (1) KR20010102428A (fr)
CN (1) CN1342148A (fr)
AU (1) AU2916500A (fr)
BR (1) BR0008608A (fr)
CA (1) CA2364908A1 (fr)
CZ (1) CZ20013164A3 (fr)
DE (1) DE19909237A1 (fr)
HU (1) HUP0200242A3 (fr)
MX (1) MXPA01008844A (fr)
NO (1) NO20014234L (fr)
PL (1) PL350941A1 (fr)
RU (1) RU2001126566A (fr)
SK (1) SK12152001A3 (fr)
WO (1) WO2000051989A1 (fr)
ZA (1) ZA200108064B (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067407B2 (en) 2008-04-23 2011-11-29 Bayer Pharma Aktiengesellschaft Substituted dihydropyrazolones and their use
US8252817B2 (en) 2005-04-28 2012-08-28 Bayer Intellectual Property Gmbh Dipyridyl-dihydropyrazolones and their use
US8389520B2 (en) 2006-10-26 2013-03-05 Bayer Intellectual Property Gmbh Substituted dihydropyrazolones for treating cardiovascular and hematological diseases
US8524699B2 (en) 2006-10-26 2013-09-03 Bayer Intellectual Property Gmbh Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors
US8609698B2 (en) 2006-10-26 2013-12-17 Bayer Intellectual Property Gmbh Substituted dipyridyl-dihydropyrazolones and use thereof
US8653074B2 (en) 2010-11-18 2014-02-18 Bayer Intellectual Property Gmbh Substituted sodium 1H-pyrazol-5-olate

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455525B1 (en) 1999-11-04 2002-09-24 Cephalon, Inc. Heterocyclic substituted pyrazolones
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
JPWO2005012255A1 (ja) * 2003-08-01 2006-09-14 三菱ウェルファーマ株式会社 炎症性関節疾患の治療剤
DE102007044032A1 (de) 2007-09-14 2009-03-19 Bayer Healthcare Ag Substituierte heterocyclische Verbindungen und ihre Verwendung
DE102007048447A1 (de) 2007-10-10 2009-04-16 Bayer Healthcare Ag Substituierte Dihydropyrazolthione und ihre Verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612353A (en) * 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
JP3994453B2 (ja) * 1995-10-13 2007-10-17 日産化学工業株式会社 ピラゾロン類

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252817B2 (en) 2005-04-28 2012-08-28 Bayer Intellectual Property Gmbh Dipyridyl-dihydropyrazolones and their use
US9085572B2 (en) 2005-04-28 2015-07-21 Bayer Intellectual Property Gmbh 4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases
US8389520B2 (en) 2006-10-26 2013-03-05 Bayer Intellectual Property Gmbh Substituted dihydropyrazolones for treating cardiovascular and hematological diseases
US8524699B2 (en) 2006-10-26 2013-09-03 Bayer Intellectual Property Gmbh Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors
US8609698B2 (en) 2006-10-26 2013-12-17 Bayer Intellectual Property Gmbh Substituted dipyridyl-dihydropyrazolones and use thereof
US20140031329A1 (en) * 2006-10-26 2014-01-30 Bayer Intellectual Property Gmbh Substituted dihydropyrazolones for treating cardiovascular and hematological diseases
US8987261B2 (en) 2006-10-26 2015-03-24 Bayer Intellectual Property Gmbh Substituted dihydropyrazolones for treating cardiovascular and hematological diseases
US20150148381A1 (en) * 2006-10-26 2015-05-28 Bayer Intellectual Property Gmbh Substituted dihydropyrazolones for treating cardiovascular and hematological diseases
US9168249B2 (en) * 2006-10-26 2015-10-27 Bayer Intellectual Property Gmbh Substituted dihydropyrazolones for treating cardiovascular and hematological diseases
US8067407B2 (en) 2008-04-23 2011-11-29 Bayer Pharma Aktiengesellschaft Substituted dihydropyrazolones and their use
US8653074B2 (en) 2010-11-18 2014-02-18 Bayer Intellectual Property Gmbh Substituted sodium 1H-pyrazol-5-olate
US9533972B2 (en) 2010-11-18 2017-01-03 Bayer Intellectual Property Gmbh Substituted sodium-1H-pyrazole-5-olate

Also Published As

Publication number Publication date
RU2001126566A (ru) 2004-02-27
SK12152001A3 (sk) 2002-03-05
HUP0200242A3 (en) 2002-12-28
PL350941A1 (en) 2003-02-24
WO2000051989A1 (fr) 2000-09-08
MXPA01008844A (es) 2002-05-14
NO20014234D0 (no) 2001-08-31
AU2916500A (en) 2000-09-21
NO20014234L (no) 2001-10-24
CN1342148A (zh) 2002-03-27
HUP0200242A2 (hu) 2002-11-28
EP1157010A1 (fr) 2001-11-28
KR20010102428A (ko) 2001-11-15
JP2002538143A (ja) 2002-11-12
CZ20013164A3 (cs) 2001-12-12
ZA200108064B (en) 2003-01-02
DE19909237A1 (de) 2000-09-07
BR0008608A (pt) 2002-01-02

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Legal Events

Date Code Title Description
FZDE Discontinued