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CA2360724A1 - Serine racemase de mammifere - Google Patents

Serine racemase de mammifere Download PDF

Info

Publication number
CA2360724A1
CA2360724A1 CA002360724A CA2360724A CA2360724A1 CA 2360724 A1 CA2360724 A1 CA 2360724A1 CA 002360724 A CA002360724 A CA 002360724A CA 2360724 A CA2360724 A CA 2360724A CA 2360724 A1 CA2360724 A1 CA 2360724A1
Authority
CA
Canada
Prior art keywords
racemase
serine
mammalian
serine racemase
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002360724A
Other languages
English (en)
Inventor
Solomon H. Snyder
Herman Wolosker
Kevin Sheth
Takahashi Masaaki
Jean-Pierre Mothet
Roscoe O. Brady, Jr.
Christopher D. Ferris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2360724A1 publication Critical patent/CA2360724A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La D-sérine se trouve à concentration élevé dans le cerveau des mammifères, où elle constitue un ligand endogène du <=site glycine>= des récepteurs NMDA. Nous avons purifié à partir du cerveau de rat une enzyme soluble qui catalyse la racémisation directe de la L-sérine en D-sérine. La sérine racémase purifiée a un poids moléculaire de 37 kDa et nécessite du pyridoxal 5'-phosphate pour son activité. L'enzyme est très sélective envers la L-sérine et ne peut réaliser la racémisation d'aucun autre acide aminé testé. Nous avons également identifié des séquences de polynucléotides qui codent pour la sérine racémase de mammifère, y compris de l'homme. Des composition qui modulent l'activité de la sérine racémase de mammifère permettent de traiter des pathologies et des maladies liées à une stimulation excessive des récepteurs NMDA, telles que les accidents vasculaires cérébraux et diverses maladies neurodégénératives.
CA002360724A 1999-01-19 2000-01-18 Serine racemase de mammifere Abandoned CA2360724A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11633399P 1999-01-19 1999-01-19
US60/116,333 1999-01-19
US14483999P 1999-07-21 1999-07-21
US60/144,839 1999-07-21
US14595399P 1999-07-28 1999-07-28
US60/145,953 1999-07-28
PCT/US2000/000938 WO2000043526A1 (fr) 1999-01-19 2000-01-18 Serine racemase de mammifere

Publications (1)

Publication Number Publication Date
CA2360724A1 true CA2360724A1 (fr) 2000-07-27

Family

ID=27381812

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002360724A Abandoned CA2360724A1 (fr) 1999-01-19 2000-01-18 Serine racemase de mammifere

Country Status (13)

Country Link
EP (1) EP1147203A1 (fr)
JP (1) JP2002534984A (fr)
KR (1) KR20010103740A (fr)
AU (1) AU2413500A (fr)
BR (1) BR0007592A (fr)
CA (1) CA2360724A1 (fr)
HU (1) HUP0105035A2 (fr)
IL (1) IL144102A0 (fr)
MX (1) MXPA01007310A (fr)
NO (1) NO20013557L (fr)
PL (1) PL364984A1 (fr)
TR (1) TR200102081T2 (fr)
WO (1) WO2000043526A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458576B1 (en) 2000-02-17 2002-10-01 Millennium Pharmaceuticals, Inc. 22406, a novel human pyridoxal-phosphate dependent enzyme family member and uses therefor
WO2001073077A2 (fr) * 2000-03-31 2001-10-04 Bayer Aktiengesellschaft Regulation de serine racemase humaine
JP2003529371A (ja) * 2000-04-04 2003-10-07 メルク エンド カムパニー インコーポレーテッド ヒトセリンラセマーゼ
JP4857071B2 (ja) * 2006-10-12 2012-01-18 潤平 笹部 筋萎縮性側策硬化症（ａｌｓ）の検出方法
CN109251923B (zh) * 2018-10-22 2021-06-15 天津博瑞威生物医药科技有限公司 丝氨酸消旋酶突变体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048266B (en) * 1979-05-09 1983-11-30 Mitsui Toatsu Chemicals Enzymatic preparation of l-tryptophan

Also Published As

Publication number Publication date
NO20013557D0 (no) 2001-07-18
PL364984A1 (en) 2004-12-27
AU2413500A (en) 2000-08-07
KR20010103740A (ko) 2001-11-23
EP1147203A1 (fr) 2001-10-24
WO2000043526A1 (fr) 2000-07-27
MXPA01007310A (es) 2002-04-24
HUP0105035A2 (hu) 2002-04-29
IL144102A0 (en) 2002-05-23
NO20013557L (no) 2001-09-19
JP2002534984A (ja) 2002-10-22
TR200102081T2 (tr) 2001-11-21
BR0007592A (pt) 2001-11-06

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued