CA2356536A1 - Alleles de sequences d'adn mitochondrial - Google Patents
Alleles de sequences d'adn mitochondrial Download PDFInfo
- Publication number
- CA2356536A1 CA2356536A1 CA 2356536 CA2356536A CA2356536A1 CA 2356536 A1 CA2356536 A1 CA 2356536A1 CA 2356536 CA2356536 CA 2356536 CA 2356536 A CA2356536 A CA 2356536A CA 2356536 A1 CA2356536 A1 CA 2356536A1
- Authority
- CA
- Canada
- Prior art keywords
- haplogroup
- nucleotide
- sample
- group
- alleles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108700028369 Alleles Proteins 0.000 title claims abstract description 121
- 108020005196 Mitochondrial DNA Proteins 0.000 title claims abstract description 18
- 239000002773 nucleotide Substances 0.000 claims abstract description 117
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 117
- 238000000034 method Methods 0.000 claims abstract description 92
- 201000010099 disease Diseases 0.000 claims abstract description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 32
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 15
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 13
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 13
- 238000003499 nucleic acid array Methods 0.000 claims abstract description 5
- 239000000758 substrate Substances 0.000 claims description 23
- 238000009396 hybridization Methods 0.000 claims description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002438 mitochondrial effect Effects 0.000 claims 1
- 102000054765 polymorphisms of proteins Human genes 0.000 abstract description 16
- 238000003491 array Methods 0.000 abstract description 8
- 239000012634 fragment Substances 0.000 description 58
- 210000003470 mitochondria Anatomy 0.000 description 52
- 108091033319 polynucleotide Proteins 0.000 description 25
- 102000040430 polynucleotide Human genes 0.000 description 25
- 239000002157 polynucleotide Substances 0.000 description 25
- 239000000523 sample Substances 0.000 description 21
- 108020004414 DNA Proteins 0.000 description 19
- 238000012163 sequencing technique Methods 0.000 description 11
- 238000002372 labelling Methods 0.000 description 7
- 241000282412 Homo Species 0.000 description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 238000012217 deletion Methods 0.000 description 4
- 230000037430 deletion Effects 0.000 description 4
- 230000035772 mutation Effects 0.000 description 4
- 108091060210 Heavy strand Proteins 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 201000000639 Leber hereditary optic neuropathy Diseases 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000013081 phylogenetic analysis Methods 0.000 description 2
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 230000009946 DNA mutation Effects 0.000 description 1
- 208000032087 Hereditary Leber Optic Atrophy Diseases 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 210000002593 Y chromosome Anatomy 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 238000004374 forensic analysis Methods 0.000 description 1
- 238000010230 functional analysis Methods 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 102000054766 genetic haplotypes Human genes 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 230000010627 oxidative phosphorylation Effects 0.000 description 1
- 230000008775 paternal effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000012950 reanalysis Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
Landscapes
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02796465A EP1432831A4 (fr) | 2001-08-30 | 2002-08-30 | Polymorphismes d'adn mitochondrial humain, haplogroupes, associations avec des conditions physiologiques et reseaux de genotypage |
| CA002459127A CA2459127A1 (fr) | 2001-08-30 | 2002-08-30 | Polymorphismes d'adn mitochondrial humain, haplogroupes, associations avec des conditions physiologiques et reseaux de genotypage |
| JP2003523626A JP2005525082A (ja) | 2001-08-30 | 2002-08-30 | ヒトミトコンドリアｄｎａ多型、ハプログループ、生理学的状態との関連、および遺伝子型決定アレイ |
| PCT/US2002/028471 WO2003018775A2 (fr) | 2001-08-30 | 2002-08-30 | Polymorphismes d'adn mitochondrial humain, haplogroupes, associations avec des conditions physiologiques et reseaux de genotypage |
| US10/488,618 US20050123913A1 (en) | 2001-08-30 | 2002-08-30 | Human mitochondrial dna polymorphisms, haplogroups, associations with physiological conditions, and genotyping arrays |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31633301P | 2001-08-30 | 2001-08-30 | |
| US60/316,333 | 2001-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2356536A1 true CA2356536A1 (fr) | 2003-02-28 |
Family
ID=23228600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2356536 Abandoned CA2356536A1 (fr) | 2001-08-30 | 2001-08-31 | Alleles de sequences d'adn mitochondrial |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2356536A1 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006238390B2 (en) * | 2005-04-18 | 2011-07-28 | Mitomics Inc. | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers |
| US10308987B2 (en) | 2005-04-18 | 2019-06-04 | Mdna Life Sciences Inc. | 3.4 kb mitochondrial DNA deletion for use in the detection of cancer |
-
2001
- 2001-08-31 CA CA 2356536 patent/CA2356536A1/fr not_active Abandoned
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006238390B2 (en) * | 2005-04-18 | 2011-07-28 | Mitomics Inc. | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers |
| US8008008B2 (en) | 2005-04-18 | 2011-08-30 | Mitomics Inc. | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers |
| US9745632B2 (en) | 2005-04-18 | 2017-08-29 | Mdna Life Sciences Inc. | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers |
| US10308987B2 (en) | 2005-04-18 | 2019-06-04 | Mdna Life Sciences Inc. | 3.4 kb mitochondrial DNA deletion for use in the detection of cancer |
| US10907213B2 (en) | 2005-04-18 | 2021-02-02 | Mdna Life Sciences Inc. | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers |
| US11111546B2 (en) | 2005-04-18 | 2021-09-07 | Mdna Life Sciences, Inc. | 3.4 KB mitochondrial DNA deletion for use in the detection of cancer |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDC | Correction of dead application (reinstatement) | ||
| FZDE | Dead |