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CA2352614A1 - Lak activity-screening materials containing lentinus extract of edodes mycelium and lak activity-screening methods using the extract - Google Patents

Lak activity-screening materials containing lentinus extract of edodes mycelium and lak activity-screening methods using the extract Download PDF

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Publication number
CA2352614A1
CA2352614A1 CA002352614A CA2352614A CA2352614A1 CA 2352614 A1 CA2352614 A1 CA 2352614A1 CA 002352614 A CA002352614 A CA 002352614A CA 2352614 A CA2352614 A CA 2352614A CA 2352614 A1 CA2352614 A1 CA 2352614A1
Authority
CA
Canada
Prior art keywords
extract
screening
lak
lak activity
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002352614A
Other languages
French (fr)
Other versions
CA2352614C (en
Inventor
Kenji Asano
Yukiko Matsuda
Yutaka Tajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kobayashi Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2352614A1 publication Critical patent/CA2352614A1/en
Application granted granted Critical
Publication of CA2352614C publication Critical patent/CA2352614C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

It is an object of the present invention to provide inexpensive materials and methods for screening immunotherapeutic agents exhibiting antitumor and/or anticancer activity.

The present invention provides a method for determining in vitro a material having an LAK
activity--enhancing effect suitable for a subject, comprising the steps of:

(a) collecting peripheral blood from the subject to prepare lymphocyte fractions, (b) preparing an LAK-induced sample and a control sample by adding or not a screening material of the present invention to said lymphocyte fractions, and (c) measuring the LAK activities of said induced sample and said control sample and comparing the results to determine the in vitro LAK activity-enhancing effect of the screening material for said subject.
CA002352614A 1998-11-27 1999-11-26 Lak activity-screening materials containing lentinus extract of edodes mycelium and lak activity-screening methods using the extract Expired - Fee Related CA2352614C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP35392698A JP4308350B2 (en) 1998-11-27 1998-11-27 LAK activity screening substance containing shiitake mycelium extract and LAK activity screening method using the same
JP10/353926 1998-11-27
PCT/JP1999/006615 WO2000033069A1 (en) 1998-11-27 1999-11-26 Substance containing shiitake mushroom hypha extract for screening lak activity and method for screening lak activity by using the same

Publications (2)

Publication Number Publication Date
CA2352614A1 true CA2352614A1 (en) 2000-06-08
CA2352614C CA2352614C (en) 2009-03-10

Family

ID=18434161

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002352614A Expired - Fee Related CA2352614C (en) 1998-11-27 1999-11-26 Lak activity-screening materials containing lentinus extract of edodes mycelium and lak activity-screening methods using the extract

Country Status (8)

Country Link
JP (1) JP4308350B2 (en)
KR (1) KR20010089498A (en)
CN (1) CN1314963C (en)
CA (1) CA2352614C (en)
GB (1) GB2360090B (en)
HK (2) HK1042745A1 (en)
TW (1) TWI222515B (en)
WO (1) WO2000033069A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101295444B1 (en) * 2011-12-22 2013-08-09 웅진식품주식회사 Novel microorganism for red ginseng fermenting, ferment solution and fermentative red ginseng drink using the same
EP2849737B1 (en) 2012-07-05 2019-09-11 Nutramax Laboratories, Inc. Compositions comprising sulforaphane or a sulforaphane precursor and a mushroom extract or powder
JP5847106B2 (en) 2013-03-25 2016-01-20 株式会社フジキン Pressure flow control device with flow monitor.
KR20240038929A (en) 2021-05-26 2024-03-26 뉴트라맥스 래보러토리즈, 인크. Composition comprising sulforaphane or sulforaphane precursor and moringa plant components

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2015294A1 (en) * 1989-04-28 1990-10-28 John J. Rinehart Generation and expansion of lak cells
US5198334A (en) * 1989-07-21 1993-03-30 Terumo Corporation Protection of natural killer cell cytolytic activity in peripheral blood mononuclear cells
US5108760A (en) * 1989-07-21 1992-04-28 Terumo Corporation Enhances lak cell activation by treatment of human peripheral blood mononuclear cells with amino acid amides
US5725855A (en) * 1991-04-05 1998-03-10 The United States Of America As Represented By The Department Of Health And Human Services Method of treating tumors with CD8+ -depleted or CD4+ T cell subpopulations
JP2002270532A (en) * 2001-03-14 2002-09-20 Tokyo Electron Ltd Heating device and thermal treatment apparatus

Also Published As

Publication number Publication date
GB2360090B (en) 2004-03-24
HK1041518B (en) 2005-03-24
HK1042745A1 (en) 2002-08-23
JP2000162204A (en) 2000-06-16
CA2352614C (en) 2009-03-10
GB2360090A (en) 2001-09-12
JP4308350B2 (en) 2009-08-05
CN1314963C (en) 2007-05-09
CN1332847A (en) 2002-01-23
KR20010089498A (en) 2001-10-06
WO2000033069A1 (en) 2000-06-08
GB0112999D0 (en) 2001-07-18
HK1041518A1 (en) 2002-07-12
TWI222515B (en) 2004-10-21

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed