CA2351731A1 - Compositions et methodes de regulation de la pathogenese bacterienne - Google Patents
Compositions et methodes de regulation de la pathogenese bacterienne Download PDFInfo
- Publication number
- CA2351731A1 CA2351731A1 CA002351731A CA2351731A CA2351731A1 CA 2351731 A1 CA2351731 A1 CA 2351731A1 CA 002351731 A CA002351731 A CA 002351731A CA 2351731 A CA2351731 A CA 2351731A CA 2351731 A1 CA2351731 A1 CA 2351731A1
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- CA
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- Prior art keywords
- autoinducer
- harveyi
- alteration
- seq
- typhimurium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
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- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 229940081974 saccharin Drugs 0.000 description 1
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- 235000019515 salmon Nutrition 0.000 description 1
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- 239000013606 secretion vector Substances 0.000 description 1
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- 239000004208 shellac Substances 0.000 description 1
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- 229940113147 shellac Drugs 0.000 description 1
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/121—Ketones acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Cette invention concerne une molécule de signalisation, purifiée, extracellulaire, d'origine bactérienne, appelée autoinducteur 2 dont la production est régulée par des modifications environnementales accompagnant le passage d'une existence libre à une existence colonisatrice ou pathogène dans un organisme hôte. La molécule de signalisation stimule des gènes de luminescence LuxQ et, apparemment, divers gènes en rapport avec la pathogenèse dans l'espèce bactérienne qui produit ladite molécule. Cette invention concerne également une nouvelle classe de gènes bactériens intervenant dans la biosynthèse de la molécule de signalisation.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11057098P | 1998-12-02 | 1998-12-02 | |
| US60/110,570 | 1998-12-02 | ||
| PCT/US1999/028751 WO2000032152A2 (fr) | 1998-12-02 | 1999-12-02 | Compositions et methodes de regulation de la pathogenese bacterienne |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2351731A1 true CA2351731A1 (fr) | 2000-06-08 |
Family
ID=22333745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002351731A Abandoned CA2351731A1 (fr) | 1998-12-02 | 1999-12-02 | Compositions et methodes de regulation de la pathogenese bacterienne |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1135144A4 (fr) |
| JP (1) | JP2003526327A (fr) |
| KR (1) | KR20010093800A (fr) |
| AU (1) | AU1933800A (fr) |
| CA (1) | CA2351731A1 (fr) |
| WO (1) | WO2000032152A2 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7326542B2 (en) * | 1998-12-02 | 2008-02-05 | Princeton University | Compositions and methods for regulating bacterial pathogenesis |
| US6559176B1 (en) | 2000-05-10 | 2003-05-06 | Princeton University | Compounds and methods for regulating bacterial growth and pathogenesis |
| US6416785B1 (en) | 2000-08-23 | 2002-07-09 | Biolitec Ag | Molecular probes for targeting of cell density-indicating compounds |
| CA2445591A1 (fr) | 2001-04-27 | 2002-11-07 | The Procter & Gamble Company | Composes heterocycliques azotes et compositions connexes servant a reguler le comportement de films biologiques |
| AU2002322010A1 (en) * | 2001-05-21 | 2002-12-03 | Quorex Pharmaceuticals, Inc. | Methods for regulating bacteria |
| US6737415B2 (en) | 2001-08-24 | 2004-05-18 | Quorex Pharmaceuticals, Inc. | Anti-bacterial agents based upon oxoanion binding |
| WO2003018046A1 (fr) | 2001-08-24 | 2003-03-06 | Quorex Pharmaceuticals, Inc. | Cristaux de luxp et complexes associes |
| US20050187190A1 (en) * | 2004-01-23 | 2005-08-25 | Sanjay Vasu | Autoinducer-2 compounds as immunomodulatory agents |
| US7405050B2 (en) | 2004-04-12 | 2008-07-29 | The Trustees Of Princeton University | Small RNAs and bacterial strains involved in quorum sensing |
| WO2005100384A2 (fr) | 2004-04-12 | 2005-10-27 | The Trustees Of Princeton University | Composes ai-2 et analogues bases sur la structure lsrb de salmonella typhimurium |
| EP1789174B1 (fr) | 2004-09-01 | 2010-06-09 | Hatch Ltd. | Asperseur composite |
| GB0620715D0 (en) | 2006-10-18 | 2006-11-29 | Univ Durham | Ethanol production |
| US8846327B2 (en) | 2007-10-17 | 2014-09-30 | Kao Corporation | Method of quantifying autoinducer-2 |
| KR101222907B1 (ko) | 2010-09-08 | 2013-01-16 | 고려대학교 산학협력단 | 여시니아 엔테로콜리티카 랜덤 지노믹 ｄｎａ 단편을 이용한 유전자 칩 |
| CN106434843A (zh) * | 2016-10-27 | 2017-02-22 | 江南大学 | 一种选择性分离培养b群链球菌的培养基及其制备方法 |
| CN115135383B (zh) | 2020-02-18 | 2024-06-11 | 吉利德科学公司 | 抗病毒化合物 |
| TWI883391B (zh) | 2020-02-18 | 2025-05-11 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| JP7688152B2 (ja) | 2021-04-16 | 2025-06-03 | ギリアード サイエンシーズ， インコーポレイテッド | アミドを使用してカルバヌクレオシドを調製する方法 |
| KR20240049311A (ko) | 2021-08-18 | 2024-04-16 | 길리애드 사이언시즈, 인코포레이티드 | 인지질 화합물 및 이의 제조 및 사용 방법 |
| CN115820605A (zh) * | 2022-10-12 | 2023-03-21 | 河南师范大学 | 一种体外合成群体感应信号分子ai-2的方法 |
| CN117305155B (zh) * | 2023-08-28 | 2024-07-05 | 江苏省家禽科学研究所 | 一种抑制沙门氏菌毒力因子的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9108307D0 (en) * | 1991-04-18 | 1991-06-05 | Univ Nottingham | Autoinducer |
| WO1993003179A1 (fr) * | 1991-07-30 | 1993-02-18 | Bio-Technical Resources | Dispositif de detection de contaminants aqueux |
| FI96697C (fi) * | 1993-08-18 | 2001-05-16 | Valio Oy | Uudet Streptococcus thermophilus -kannat ja niiden käyttö antibioottie n määrittämiseen |
-
1999
- 1999-12-02 WO PCT/US1999/028751 patent/WO2000032152A2/fr not_active Ceased
- 1999-12-02 KR KR1020017006954A patent/KR20010093800A/ko not_active Withdrawn
- 1999-12-02 AU AU19338/00A patent/AU1933800A/en not_active Abandoned
- 1999-12-02 JP JP2000584850A patent/JP2003526327A/ja active Pending
- 1999-12-02 EP EP99963011A patent/EP1135144A4/fr not_active Withdrawn
- 1999-12-02 CA CA002351731A patent/CA2351731A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000032152A2 (fr) | 2000-06-08 |
| WO2000032152A3 (fr) | 2002-12-12 |
| AU1933800A (en) | 2000-06-19 |
| KR20010093800A (ko) | 2001-10-29 |
| JP2003526327A (ja) | 2003-09-09 |
| EP1135144A1 (fr) | 2001-09-26 |
| EP1135144A4 (fr) | 2005-07-20 |
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