CA2349837A1 - Traitement d'infections au moyen de proteines de fusion lysozyme - Google Patents
Traitement d'infections au moyen de proteines de fusion lysozyme Download PDFInfo
- Publication number
- CA2349837A1 CA2349837A1 CA002349837A CA2349837A CA2349837A1 CA 2349837 A1 CA2349837 A1 CA 2349837A1 CA 002349837 A CA002349837 A CA 002349837A CA 2349837 A CA2349837 A CA 2349837A CA 2349837 A1 CA2349837 A1 CA 2349837A1
- Authority
- CA
- Canada
- Prior art keywords
- leu
- lysozyme
- ala
- seq
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2462—Lysozyme (3.2.1.17)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne une méthode et une composition destinées au traitement prophylactique et curatif d'infections bactériennes, en particulier au niveau des voies respiratoires. Une protéine de fusion de lysozyme et du propeptide C-terminal de la protéine tensioactive B (SP-B) avec les dix acides aminés précédents du peptide SP-B mature, ou le lysozyme recombinant seul, est administré à un patient via un support acceptable au plan pharmaceutique. La protéine de fusion seule ou le lysoszyme recombinant peut être sélectionné de manière à pouvoir être administré sur un site d'infection cible, tel que les poumons ou l'appareil gastro-intestinal. Ce procédé et cette composition permettent d'éviter certains problèmes associés à des traitements antibiotiques classiques, tels que la perte d'efficacité ou le développement de souches bactériennes résistant aux antibiotiques.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/193,877 US5993809A (en) | 1998-11-18 | 1998-11-18 | Lysozyme fusion proteins in infections |
| US09/193,877 | 1998-11-18 | ||
| US44074299A | 1999-11-16 | 1999-11-16 | |
| US09/440,742 | 1999-11-16 | ||
| PCT/US1999/027403 WO2000029588A1 (fr) | 1998-11-18 | 1999-11-18 | Traitement d'infections au moyen de proteines de fusion lysozyme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2349837A1 true CA2349837A1 (fr) | 2000-05-25 |
Family
ID=26889453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002349837A Abandoned CA2349837A1 (fr) | 1998-11-18 | 1999-11-18 | Traitement d'infections au moyen de proteines de fusion lysozyme |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1129201A1 (fr) |
| JP (1) | JP2002530083A (fr) |
| AU (1) | AU759743B2 (fr) |
| BR (1) | BR9915218A (fr) |
| CA (1) | CA2349837A1 (fr) |
| WO (1) | WO2000029588A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1194570A1 (fr) | 1999-06-23 | 2002-04-10 | PPL Therapeutics (Scotland) Limited | Proteines de fusion incorporant un lysozyme |
| EP1694848B1 (fr) | 2003-12-18 | 2010-03-03 | Justus-Liebig-Universität Giessen | Nouveaux activateurs chimeres du plasminogene et leur utilisation a des fins pharmaceutiques |
| WO2005108563A2 (fr) * | 2004-04-19 | 2005-11-17 | University Of Chicago | Proteine hydrolysant le peptidoglycane encodée par bacteriophage n4 |
| AU2006207998A1 (en) | 2005-01-27 | 2006-08-03 | Novartis Vaccines And Diagnostics Inc. | A method for characterizing the efficacy of an agent targeting a primary cystic fibrosis defect |
| EP2697387B1 (fr) * | 2011-04-12 | 2021-09-15 | Bactoclear Holdings PTE. LTD. | Polypeptides chimères antibactériens |
| CN104817618B (zh) * | 2014-01-30 | 2018-07-03 | 陈光健 | 寡肽cd01及其制备方法和应用 |
| CN104817616A (zh) * | 2014-01-30 | 2015-08-05 | 陈光健 | 寡肽cd02及其制备方法和应用 |
| CN114149986B (zh) * | 2022-02-08 | 2022-05-06 | 中国科学院天津工业生物技术研究所 | 一种地衣芽孢杆菌溶菌酶突变体及其在虹鳟鱼保鲜中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3540075A1 (de) * | 1985-11-12 | 1987-05-14 | Boehringer Ingelheim Int | Human-lysozym |
| DE3818094C1 (fr) * | 1988-05-27 | 1989-07-20 | Medichemie Ag, Ettingen, Ch | |
| US5006343A (en) * | 1988-12-29 | 1991-04-09 | Benson Bradley J | Pulmonary administration of pharmaceutically active substances |
-
1999
- 1999-11-18 WO PCT/US1999/027403 patent/WO2000029588A1/fr not_active Ceased
- 1999-11-18 AU AU23459/00A patent/AU759743B2/en not_active Ceased
- 1999-11-18 EP EP99967112A patent/EP1129201A1/fr not_active Withdrawn
- 1999-11-18 CA CA002349837A patent/CA2349837A1/fr not_active Abandoned
- 1999-11-18 JP JP2000582571A patent/JP2002530083A/ja active Pending
- 1999-11-18 BR BR9915218-5A patent/BR9915218A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2345900A (en) | 2000-06-05 |
| JP2002530083A (ja) | 2002-09-17 |
| WO2000029588A1 (fr) | 2000-05-25 |
| BR9915218A (pt) | 2001-07-31 |
| EP1129201A1 (fr) | 2001-09-05 |
| AU759743B2 (en) | 2003-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |