CA2346264A1 - Glypicanes servant a detecter et a traiter le carcinome humain - Google Patents
Glypicanes servant a detecter et a traiter le carcinome humain Download PDFInfo
- Publication number
- CA2346264A1 CA2346264A1 CA002346264A CA2346264A CA2346264A1 CA 2346264 A1 CA2346264 A1 CA 2346264A1 CA 002346264 A CA002346264 A CA 002346264A CA 2346264 A CA2346264 A CA 2346264A CA 2346264 A1 CA2346264 A1 CA 2346264A1
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- Prior art keywords
- glypican
- cells
- growth factor
- binding
- expression
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- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4725—Proteoglycans, e.g. aggreccan
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04011—Phosphoinositide phospholipase C (3.1.4.11)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57469—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving tumor associated glycolinkage, i.e. TAG
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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Abstract
Glypicane-1 HSPG ancré à glycosylphosphatidylinositol- (GPI-) est fortement exprimé dans le cancer du sein et du pancréas chez l'humain à la fois par les cellules cancéreuses et par les fibroblastes contigus dans le cas du cancer du pancréas, alors que l'expression de glypicane-1 est basse dans le pancréas normal et dans la pancréatite chronique. Le traitement de deux lignées cellulaires du cancer du pancréas, exprimant glypicane-1, par l'enzyme phospholipase-C spécifique pour phosphoinositide (PI-PLC) a supprimé leurs réactions mitogéniques à deux facteurs de croissance se fixant à héparine: le facteur-2 de croissance des fibroblastes (FGF2) et le facteur de croissance semblable à EGF se fixant à héparine (HB-EGF). Le traitement des cellules du cancer du sein MDA-MB-231 et MDA-MB-468 par PI-PLC a supprimé la réaction mitogénique à deux facteurs de croissance se fixant à héparine, le facteur de croissance semblable au facteur de croissance épidermique se fixant à héparine (HB-EGF) et le facteur-2 de croissance des fibroblastes (FGF-2). Syndecane-1 est également exprimé à des niveaux importants dans des tissus du cancer du sein, ainsi que dans des cellules du cancer du sein, par rapport à des tissus normaux du sein. La transfection temporaire ou permanente d'un produit génétique antisens de glypicane-1 a atténué les niveaux de protéines de glypicane-1 et la réaction mitogénique à FGF2 et HB-EGF. On peut utiliser glypicane afin de détecter le carcinome in vitro et des substances thérapeutiques qui soit se fixent (par exemple, anticorps ou médicaments) à la surface du domaine extracellulaire de glypicane-1, soit en suppriment (par exemple, enzymes) ou en empêchent l'expression (par exemple, produits génétiques antisens), sont efficaces pour retarder la croissance de carcinomes réactifs à glypicane.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10451098P | 1998-10-16 | 1998-10-16 | |
| US60/104,510 | 1998-10-16 | ||
| US12162499P | 1999-02-25 | 1999-02-25 | |
| US60/121,624 | 1999-02-25 | ||
| PCT/US1999/024176 WO2000023109A1 (fr) | 1998-10-16 | 1999-10-15 | Glypicanes servant a detecter et a traiter le carcinome humain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2346264A1 true CA2346264A1 (fr) | 2000-04-27 |
Family
ID=26801634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002346264A Abandoned CA2346264A1 (fr) | 1998-10-16 | 1999-10-15 | Glypicanes servant a detecter et a traiter le carcinome humain |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1146903A4 (fr) |
| AU (1) | AU769125B2 (fr) |
| CA (1) | CA2346264A1 (fr) |
| WO (1) | WO2000023109A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2454135A1 (fr) * | 2001-07-12 | 2003-01-23 | Exelixis, Inc. | Glypicanes (gpc) utiles en tant que modificateurs des mecanismes de irrtk et de p21, methodes d'utilisation correspondantes |
| WO2004022597A1 (fr) * | 2002-09-04 | 2004-03-18 | Chugai Seiyaku Kabushiki Kaisha | Anticorps d'un peptide n-terminal du gpc3 solubilise dans le sang |
| CA2482881C (fr) * | 2002-05-23 | 2016-11-08 | Sunnybrook And Women's College Health Sciences Centre | Diagnostic de carcinome hepatocellulaire |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| KR102435383B1 (ko) * | 2015-01-16 | 2022-08-24 | 미노믹 인터내셔널 리미티드 | 글리피칸 에피토프 및 이의 용도 |
| US11198738B2 (en) * | 2015-04-20 | 2021-12-14 | Minomic International Ltd. | Therapeutic antibodies and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0569367T3 (da) * | 1991-01-15 | 1998-10-07 | Biotie Therapies Oy | Detektering af syndecanindhold i biologiske materialer, såsom væv og kropsvæsker, som indikationer på maligne transformatio |
-
1999
- 1999-10-15 WO PCT/US1999/024176 patent/WO2000023109A1/fr not_active Ceased
- 1999-10-15 AU AU11181/00A patent/AU769125B2/en not_active Ceased
- 1999-10-15 EP EP99954963A patent/EP1146903A4/fr not_active Withdrawn
- 1999-10-15 CA CA002346264A patent/CA2346264A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU1118100A (en) | 2000-05-08 |
| AU769125B2 (en) | 2004-01-15 |
| WO2000023109A1 (fr) | 2000-04-27 |
| EP1146903A4 (fr) | 2005-02-16 |
| EP1146903A1 (fr) | 2001-10-24 |
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