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CA2344398A1 - Micro-aiguilles micro-usinees sur une surface - Google Patents

Micro-aiguilles micro-usinees sur une surface Download PDF

Info

Publication number
CA2344398A1
CA2344398A1 CA002344398A CA2344398A CA2344398A1 CA 2344398 A1 CA2344398 A1 CA 2344398A1 CA 002344398 A CA002344398 A CA 002344398A CA 2344398 A CA2344398 A CA 2344398A CA 2344398 A1 CA2344398 A1 CA 2344398A1
Authority
CA
Canada
Prior art keywords
microneedle
microneedles
array device
microneedle array
substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002344398A
Other languages
English (en)
Inventor
A. Bruno Frazier
John D. Brazzle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2344398A1 publication Critical patent/CA2344398A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C99/00—Subject matter not provided for in other groups of this subclass
    • B81C99/0075—Manufacture of substrate-free structures
    • B81C99/008—Manufacture of substrate-free structures separating the processed structure from a mother substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D1/00—Electroforming
    • C25D1/02—Tubes; Rings; Hollow bodies

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Manufacturing & Machinery (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Micromachines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne des micro-aiguilles (32) micro-usinées sur une surface, réalisées sous forme d'aiguilles prises une à une (32) ou montées en matrices bidimensionnelles ou tridimensionnelles (30). Ces micro-aiguilles (32) sont fabriquées sur un substrat (12) qui peut rester solidaire des micro-aiguilles (32) ou peut en être séparé ultérieurement. Ces matrices bidimensionnelles ou tridimensionnelles de micro-aiguilles (30) peuvent comporter des canaux d'écoulement à couplage croisé (36) qui assurent un équilibrage des pressions et de l'écoulement du fluide dans les matrices de micro-aiguilles (30). Chaque micro-aiguille (32) est traversée d'un micro-canal (36) qui met en communication au moins un orifice d'entrée (37) à l'extrémité proximale des micro-aiguilles (32), et au moins un orifice de sortie (39), de l'autre côté, à l'extrémité distale.
CA002344398A 1998-09-18 1999-09-17 Micro-aiguilles micro-usinees sur une surface Abandoned CA2344398A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10106498P 1998-09-18 1998-09-18
US60/101,064 1998-09-18
PCT/US1999/021509 WO2000016833A1 (fr) 1998-09-18 1999-09-17 Micro-aiguilles micro-usinees sur une surface

Publications (1)

Publication Number Publication Date
CA2344398A1 true CA2344398A1 (fr) 2000-03-30

Family

ID=22282911

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002344398A Abandoned CA2344398A1 (fr) 1998-09-18 1999-09-17 Micro-aiguilles micro-usinees sur une surface

Country Status (5)

Country Link
EP (1) EP1113832A4 (fr)
JP (1) JP2002526273A (fr)
AU (1) AU6151599A (fr)
CA (1) CA2344398A1 (fr)
WO (1) WO2000016833A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US6982058B2 (en) 1999-12-08 2006-01-03 Baxter International, Inc. Method for fabricating three dimensional structures
WO2001041905A1 (fr) 1999-12-08 2001-06-14 Baxter International Inc. Membrane filtrante microporeuse, procede de fabrication et separateur utilisant de telles membranes
US6659982B2 (en) 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US7473244B2 (en) 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US7004928B2 (en) * 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
JP3933058B2 (ja) * 2002-02-25 2007-06-20 日立化成工業株式会社 マイクロ流体システム用支持ユニット及びその製造方法
JP4500851B2 (ja) 2004-03-12 2010-07-14 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 横穴付きマイクロ針の製造に使用するための方法および型
EP1832861B1 (fr) 2004-11-30 2020-04-29 Hitachi Chemical Company, Ltd. Dispositif de pretraitement analytique
DE102005030858A1 (de) * 2005-07-01 2007-01-04 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Elektrodenanordnung, deren Verwendung sowie Verfahren zu deren Herstellung
DE102005030859A1 (de) * 2005-07-01 2007-01-04 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Elektrodenanordnung, deren Verwendung sowie Verfahren zu deren Herstellung
JP2007229825A (ja) * 2006-02-27 2007-09-13 Hirosaki Univ 微小電気機械構造、その製造方法および微小電気機械素子
WO2008027011A1 (fr) * 2006-08-28 2008-03-06 Agency For Science, Technology And Research Micro-aiguilles et procédés pour fabriquer des micro-aiguilles
FI20095433A0 (fi) 2009-04-20 2009-04-20 Valtion Teknillinen Mikroneula
US8062568B2 (en) * 2009-08-27 2011-11-22 Korea University Research And Business Foundation Nano pattern writer
JP5629503B2 (ja) * 2010-06-23 2014-11-19 見城　晃 注射針の製造方法および注射針
CN104874098B (zh) * 2015-04-08 2018-04-10 上海交通大学 一种空心金属微针及其批量制备方法
CN109336049B (zh) * 2018-10-11 2023-10-24 宁波大学 一种微结构操作方法及操作装置
JP2023523952A (ja) 2020-04-28 2023-06-08 ティコナ・エルエルシー マイクロニードルアセンブリ

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2221394B (en) * 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
US5312456A (en) * 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
CA2205444A1 (fr) * 1994-12-09 1996-06-13 Novartis Ag Systeme transdermique
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5871158A (en) * 1997-01-27 1999-02-16 The University Of Utah Research Foundation Methods for preparing devices having metallic hollow microchannels on planar substrate surfaces

Also Published As

Publication number Publication date
EP1113832A4 (fr) 2002-04-17
AU6151599A (en) 2000-04-10
EP1113832A1 (fr) 2001-07-11
JP2002526273A (ja) 2002-08-20
WO2000016833A1 (fr) 2000-03-30

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued