CA2341518A1 - Genes regules par l'hypoxie - Google Patents
Genes regules par l'hypoxie Download PDFInfo
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- CA2341518A1 CA2341518A1 CA002341518A CA2341518A CA2341518A1 CA 2341518 A1 CA2341518 A1 CA 2341518A1 CA 002341518 A CA002341518 A CA 002341518A CA 2341518 A CA2341518 A CA 2341518A CA 2341518 A1 CA2341518 A1 CA 2341518A1
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
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- Engineering & Computer Science (AREA)
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- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
L'invention concerne la séquence polynucléotidique d'un gène dont l'expression est modulée par des états hypoxiques. L'invention concerne également une séquence polynucléotidique codant un gène pour la protéine 2-2-83, une composition pharmaceutique de modulation de l'hypoxie et de l'ischémie qui contient une quantité effective d'un polynucléotide ou d'une protéine comportant la séquence nucléotidique d'après les séquences SEQ ID Nos 1 et 2 ou des analogues fonctionnels desdites séquences et un support pharmaceutiquement acceptable. On décrit un procédé de régulation de pathologies et d'une tumorigenèse associées à l'hypoxie, par administration d'une quantité effective d'un polynucléotide, d'une protéine, d'un produit direct ou indirect biologiquement actif de l'activité enzymatique de la protéine, ou d'inhibiteurs du produit direct ou indirect biologiquement actif de l'activité enzymatique de la protéine ayant une séquence d'acide nucléique issue d'au moins un élément du groupe contenant les séquences SEQ ID Nos 1 et 2 et des analogues fonctionnels desdites séquences et un support pharmaceutiquement acceptable. On décrit également un procédé de régulation de pathologies et d'une tumorigenèse associées à l'hypoxie, par inhibition de l'activité enzymatique de la protéine codée par les séquences polynucléotidiques issues d'au moins un élément du groupe contenant les séquences SEQ ID Nos 1 et 2 et des analogues fonctionnels desdites séquences. L'invention concerne en outre une régulation de la réaction à l'hypoxie, ainsi que des agents neuroprotecteurs et neurotrophiques comprenant un produit génique des séquences polynucléotidiques de 2-2-83, d'après les séquences SEQ ID Nos 1 et 2 et des analogues fonctionnels desdites séquences. L'invention concerne enfin un procédé pour diagnostiquer la présence d'une pathologie ou d'une tumorigenèse associée à l'hypoxie, par criblage pour l'expression réduite du gène codé par la séquence d'acide nucléique, d'après les séquences SEQ ID Nos 1 et 2 et des analogues fonctionnels desdites séquences.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9815898P | 1998-08-27 | 1998-08-27 | |
| US13268499P | 1999-05-05 | 1999-05-05 | |
| US60/098,158 | 1999-05-05 | ||
| US60/132,684 | 1999-05-05 | ||
| PCT/US1999/020393 WO2000012139A1 (fr) | 1998-08-27 | 1999-08-27 | Genes regules par l'hypoxie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2341518A1 true CA2341518A1 (fr) | 2000-03-09 |
Family
ID=26794273
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002341705A Abandoned CA2341705A1 (fr) | 1998-08-27 | 1999-08-27 | Sequences caracteristiques de la transcription genique regulee par l'hypoxemie |
| CA002341518A Abandoned CA2341518A1 (fr) | 1998-08-27 | 1999-08-27 | Genes regules par l'hypoxie |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002341705A Abandoned CA2341705A1 (fr) | 1998-08-27 | 1999-08-27 | Sequences caracteristiques de la transcription genique regulee par l'hypoxemie |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP1115733A4 (fr) |
| JP (2) | JP2002523072A (fr) |
| AU (1) | AU5810999A (fr) |
| CA (2) | CA2341705A1 (fr) |
| IL (2) | IL141660A0 (fr) |
| WO (2) | WO2000012525A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4175662B2 (ja) | 1996-01-08 | 2008-11-05 | インパルス ダイナミクス エヌ．ヴイ． | 電気的筋肉制御装置 |
| US9289618B1 (en) | 1996-01-08 | 2016-03-22 | Impulse Dynamics Nv | Electrical muscle controller |
| US9713723B2 (en) | 1996-01-11 | 2017-07-25 | Impulse Dynamics Nv | Signal delivery through the right ventricular septum |
| EP1002862A1 (fr) * | 1998-11-12 | 2000-05-24 | Nitsch, Roger M., Prof. Dr. | Procédés pour diagnostiquer ou traiter des maladies neurologiques |
| US9101765B2 (en) | 1999-03-05 | 2015-08-11 | Metacure Limited | Non-immediate effects of therapy |
| WO2006073671A1 (fr) | 2004-12-09 | 2006-07-13 | Impulse Dynamics Nv | Modification de l'activite proteique |
| NZ526617A (en) * | 2000-11-28 | 2004-09-24 | Wyeth Corp | Expression analysis of KIAA nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
| ATE478147T1 (de) * | 2001-05-31 | 2010-09-15 | Chiba Prefecture | Aus einem neuroblastom isolierte nukleinsäuren |
| US20030068636A1 (en) | 2001-06-21 | 2003-04-10 | Millennium Pharmaceuticals, Inc. | Compositions, kits and methods for identification, assessment, prevention, and therapy of breast and ovarian cancer |
| JP2006515747A (ja) * | 2002-11-01 | 2006-06-08 | ジェネンテック・インコーポレーテッド | 免疫関連疾患の治療のための組成物と方法 |
| US11439815B2 (en) | 2003-03-10 | 2022-09-13 | Impulse Dynamics Nv | Protein activity modification |
| EP1670425A4 (fr) * | 2003-10-07 | 2008-04-16 | Quark Pharmaceuticals Inc | Proteine morphogenetique (bmp) 2a de l'os et ses utilisations |
| US11779768B2 (en) | 2004-03-10 | 2023-10-10 | Impulse Dynamics Nv | Protein activity modification |
| EP1898991B1 (fr) | 2005-05-04 | 2016-06-29 | Impulse Dynamics NV | Modification d'activite de proteine |
| WO2011092710A2 (fr) | 2010-02-01 | 2011-08-04 | Metacure Limited | Thérapie électrique gastro-intestinale |
| JP2011206049A (ja) * | 2010-03-08 | 2011-10-20 | Sumio Sugano | 壊死マーカー及びその用途 |
| JP2013220090A (ja) * | 2012-04-19 | 2013-10-28 | Tohoku Univ | 眼疾患治療に使用する薬剤スクリーニング方法 |
| AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2240492A (en) | 1991-06-20 | 1993-01-25 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | Sequences characteristic of human gene transcription product |
| US5731294A (en) * | 1993-07-27 | 1998-03-24 | Hybridon, Inc. | Inhibition of neovasularization using VEGF-specific oligonucleotides |
| US5882914A (en) * | 1995-06-06 | 1999-03-16 | The Johns Hopkins University School Of Medicine | Nucleic acids encoding the hypoxia inducible factor-1 |
| CA2283299A1 (fr) * | 1997-03-07 | 1998-09-11 | Human Genome Sciences, Inc. | 186 nouvelles proteines secretees |
| EP1002862A1 (fr) * | 1998-11-12 | 2000-05-24 | Nitsch, Roger M., Prof. Dr. | Procédés pour diagnostiquer ou traiter des maladies neurologiques |
-
1999
- 1999-08-27 AU AU58109/99A patent/AU5810999A/en not_active Abandoned
- 1999-08-27 CA CA002341705A patent/CA2341705A1/fr not_active Abandoned
- 1999-08-27 EP EP99945523A patent/EP1115733A4/fr not_active Withdrawn
- 1999-08-27 WO PCT/US1999/020394 patent/WO2000012525A1/fr not_active Ceased
- 1999-08-27 JP JP2000567249A patent/JP2002523072A/ja active Pending
- 1999-08-27 WO PCT/US1999/020393 patent/WO2000012139A1/fr not_active Ceased
- 1999-08-27 EP EP99945522A patent/EP1107797A4/fr not_active Withdrawn
- 1999-08-27 JP JP2000571058A patent/JP2002525081A/ja active Pending
- 1999-08-27 IL IL14166099A patent/IL141660A0/xx unknown
- 1999-08-27 CA CA002341518A patent/CA2341518A1/fr not_active Abandoned
- 1999-08-27 IL IL14166699A patent/IL141666A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002523072A (ja) | 2002-07-30 |
| WO2000012139A1 (fr) | 2000-03-09 |
| CA2341705A1 (fr) | 2000-03-09 |
| AU5810999A (en) | 2000-03-21 |
| IL141660A0 (en) | 2002-03-10 |
| EP1107797A4 (fr) | 2002-10-16 |
| WO2000012139B1 (fr) | 2000-05-04 |
| WO2000012525A1 (fr) | 2000-03-09 |
| EP1115733A4 (fr) | 2003-01-22 |
| JP2002525081A (ja) | 2002-08-13 |
| EP1107797A2 (fr) | 2001-06-20 |
| IL141666A0 (en) | 2002-03-10 |
| EP1115733A1 (fr) | 2001-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |