CA2239205A1 - Prolongation de la duree de vie par surexpression d'un gene qui augmente le metabolisme d'oxygene reactif - Google Patents
Prolongation de la duree de vie par surexpression d'un gene qui augmente le metabolisme d'oxygene reactif Download PDFInfo
- Publication number
- CA2239205A1 CA2239205A1 CA 2239205 CA2239205A CA2239205A1 CA 2239205 A1 CA2239205 A1 CA 2239205A1 CA 2239205 CA2239205 CA 2239205 CA 2239205 A CA2239205 A CA 2239205A CA 2239205 A1 CA2239205 A1 CA 2239205A1
- Authority
- CA
- Canada
- Prior art keywords
- gene
- sod
- disease
- reactive oxygen
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000623 proteins and genes Proteins 0.000 title claims description 83
- 230000008557 oxygen metabolism Effects 0.000 title claims description 11
- 230000002018 overexpression Effects 0.000 title description 7
- 210000002161 motor neuron Anatomy 0.000 claims description 51
- 230000014509 gene expression Effects 0.000 claims description 33
- 210000004027 cell Anatomy 0.000 claims description 27
- 230000000694 effects Effects 0.000 claims description 25
- 102000004169 proteins and genes Human genes 0.000 claims description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 17
- 101150017120 sod gene Proteins 0.000 claims description 17
- 230000015572 biosynthetic process Effects 0.000 claims description 13
- 239000013598 vector Substances 0.000 claims description 12
- 238000003786 synthesis reaction Methods 0.000 claims description 11
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 10
- 230000002159 abnormal effect Effects 0.000 claims description 9
- 208000035475 disorder Diseases 0.000 claims description 9
- 230000001105 regulatory effect Effects 0.000 claims description 7
- 108010053835 Catalase Proteins 0.000 claims description 6
- 239000012634 fragment Substances 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 239000001301 oxygen Substances 0.000 claims description 6
- 102000006587 Glutathione peroxidase Human genes 0.000 claims description 5
- 108700016172 Glutathione peroxidases Proteins 0.000 claims description 5
- 229930003427 Vitamin E Natural products 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 235000019165 vitamin E Nutrition 0.000 claims description 5
- 229940046009 vitamin E Drugs 0.000 claims description 5
- 239000011709 vitamin E Substances 0.000 claims description 5
- 102100027186 Extracellular superoxide dismutase [Cu-Zn] Human genes 0.000 claims description 4
- 101000836222 Homo sapiens Extracellular superoxide dismutase [Cu-Zn] Proteins 0.000 claims description 4
- 230000002292 Radical scavenging effect Effects 0.000 claims description 4
- 102100032891 Superoxide dismutase [Mn], mitochondrial Human genes 0.000 claims description 4
- 230000001965 increasing effect Effects 0.000 claims description 4
- 230000037345 metabolism of vitamins Effects 0.000 claims description 4
- 108010045815 superoxide dismutase 2 Proteins 0.000 claims description 4
- 208000024827 Alzheimer disease Diseases 0.000 claims description 3
- 208000023105 Huntington disease Diseases 0.000 claims description 3
- 208000018737 Parkinson disease Diseases 0.000 claims description 3
- 201000010901 lateral sclerosis Diseases 0.000 claims description 3
- 208000005264 motor neuron disease Diseases 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 64
- 102000019197 Superoxide Dismutase Human genes 0.000 description 62
- 241000255925 Diptera Species 0.000 description 28
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 24
- 108700019146 Transgenes Proteins 0.000 description 23
- 102100039556 Galectin-4 Human genes 0.000 description 21
- 101000608765 Homo sapiens Galectin-4 Proteins 0.000 description 21
- 230000004060 metabolic process Effects 0.000 description 20
- 235000018102 proteins Nutrition 0.000 description 16
- 210000000349 chromosome Anatomy 0.000 description 15
- 230000002068 genetic effect Effects 0.000 description 15
- 230000035772 mutation Effects 0.000 description 14
- 230000009261 transgenic effect Effects 0.000 description 10
- 230000032683 aging Effects 0.000 description 9
- 239000012190 activator Substances 0.000 description 8
- 239000002773 nucleotide Substances 0.000 description 8
- 125000003729 nucleotide group Chemical group 0.000 description 8
- 210000000609 ganglia Anatomy 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 210000004556 brain Anatomy 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 4
- 238000012217 deletion Methods 0.000 description 4
- 230000037430 deletion Effects 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 238000001415 gene therapy Methods 0.000 description 4
- 239000005090 green fluorescent protein Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 230000004792 oxidative damage Effects 0.000 description 4
- FIKAKWIAUPDISJ-UHFFFAOYSA-L paraquat dichloride Chemical compound [Cl-].[Cl-].C1=C[N+](C)=CC=C1C1=CC=[N+](C)C=C1 FIKAKWIAUPDISJ-UHFFFAOYSA-L 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 3
- 239000006783 corn meal agar Substances 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000005865 ionizing radiation Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 210000000653 nervous system Anatomy 0.000 description 3
- 210000002569 neuron Anatomy 0.000 description 3
- 230000036542 oxidative stress Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 108700028369 Alleles Proteins 0.000 description 2
- 102000016938 Catalase Human genes 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 2
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 238000006701 autoxidation reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 208000019995 familial amyotrophic lateral sclerosis Diseases 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 238000003119 immunoblot Methods 0.000 description 2
- 210000001153 interneuron Anatomy 0.000 description 2
- 230000001418 larval effect Effects 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 230000037323 metabolic rate Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- DIVDFFZHCJEHGG-UHFFFAOYSA-N oxidopamine Chemical compound NCCC1=CC(O)=C(O)C=C1O DIVDFFZHCJEHGG-UHFFFAOYSA-N 0.000 description 2
- 230000036284 oxygen consumption Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000009758 senescence Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 229940116269 uric acid Drugs 0.000 description 2
- OZDAOHVKBFBBMZ-UHFFFAOYSA-N 2-aminopentanedioic acid;hydrate Chemical compound O.OC(=O)C(N)CCC(O)=O OZDAOHVKBFBBMZ-UHFFFAOYSA-N 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000012639 Balance disease Diseases 0.000 description 1
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229910002535 CuZn Inorganic materials 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108091060211 Expressed sequence tag Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
- 108010005730 R-SNARE Proteins Proteins 0.000 description 1
- 108700008625 Reporter Genes Proteins 0.000 description 1
- 238000010632 SOD assay Methods 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 108010021188 Superoxide Dismutase-1 Proteins 0.000 description 1
- 102000008221 Superoxide Dismutase-1 Human genes 0.000 description 1
- 102000002215 Synaptobrevin Human genes 0.000 description 1
- 241000255588 Tephritidae Species 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 102000004603 Vesicle-Associated Membrane Protein 1 Human genes 0.000 description 1
- 108010017743 Vesicle-Associated Membrane Protein 1 Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 210000001766 X chromosome Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000011461 current therapy Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 231100000880 dysequilibrium Toxicity 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000006353 environmental stress Effects 0.000 description 1
- 210000002468 fat body Anatomy 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 230000000574 ganglionic effect Effects 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- DLINORNFHVEIFE-UHFFFAOYSA-N hydrogen peroxide;zinc Chemical compound [Zn].OO DLINORNFHVEIFE-UHFFFAOYSA-N 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 210000005044 neurofilament Anatomy 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 230000007171 neuropathology Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- -1 oxygen radical Chemical class 0.000 description 1
- 230000001769 paralizing effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 108091006106 transcriptional activators Proteins 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2239205 CA2239205A1 (fr) | 1998-05-29 | 1998-05-29 | Prolongation de la duree de vie par surexpression d'un gene qui augmente le metabolisme d'oxygene reactif |
| CA 2273173 CA2273173A1 (fr) | 1998-05-29 | 1999-05-28 | Prolongation de la longevite par la surexpression d'un gene qui accroit le metabolisme reactif d'oxygene |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2239205 CA2239205A1 (fr) | 1998-05-29 | 1998-05-29 | Prolongation de la duree de vie par surexpression d'un gene qui augmente le metabolisme d'oxygene reactif |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2239205A1 true CA2239205A1 (fr) | 1999-11-29 |
Family
ID=29275805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2239205 Abandoned CA2239205A1 (fr) | 1998-05-29 | 1998-05-29 | Prolongation de la duree de vie par surexpression d'un gene qui augmente le metabolisme d'oxygene reactif |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2239205A1 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2698153A1 (fr) * | 2001-12-18 | 2014-02-19 | Brassica Foundation for Chemoprotection Research, Inc. | Prévention et traitement d'affections liées au stress oxydatif par des composés qui augmentent les niveaux intracellulaires de glutathione ou des enzymes de détoxification de phase II |
| CN117316295A (zh) * | 2023-09-13 | 2023-12-29 | 哈尔滨工业大学 | 一种基于细胞异质性基因与通路功能的内分泌疾病细胞识别方法 |
-
1998
- 1998-05-29 CA CA 2239205 patent/CA2239205A1/fr not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2698153A1 (fr) * | 2001-12-18 | 2014-02-19 | Brassica Foundation for Chemoprotection Research, Inc. | Prévention et traitement d'affections liées au stress oxydatif par des composés qui augmentent les niveaux intracellulaires de glutathione ou des enzymes de détoxification de phase II |
| CN117316295A (zh) * | 2023-09-13 | 2023-12-29 | 哈尔滨工业大学 | 一种基于细胞异质性基因与通路功能的内分泌疾病细胞识别方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Parkes et al. | Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons | |
| Seto et al. | Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-span. | |
| Schwarze et al. | Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila | |
| Wallace | Animal models for mitochondrial disease | |
| Aigaki et al. | Longevity determination genes in Drosophila melanogaster | |
| Phillips et al. | Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. | |
| Melov et al. | Mouse models of mitochondrial disease, oxidative stress, and senescence | |
| Pandolfo | Molecular genetics and pathogenesis of Friedreich ataxia | |
| Garzino et al. | Cell lineage‐specific expression of modulo, a dose‐dependent modifier of variegation in Drosophila. | |
| Kim et al. | Transcriptional regulation and life-span modulation of cytosolic aconitase and ferritin genes in C. elegans | |
| Kunst et al. | Genetic mapping of a mouse modifier gene that can prevent ALS onset | |
| JP2020010707A (ja) | snoRNA、組成物、及び使用 | |
| Bhole et al. | Doxycycline-regulated over-expression of hsp22 has negative effects on stress resistance and life span in adult Drosophila melanogaster | |
| Quintero-Espinosa et al. | Knockdown transgenic Lrrk Drosophila resists paraquat-induced locomotor impairment and neurodegeneration: A therapeutic strategy for Parkinson’s disease | |
| Huen et al. | Dynamic regulation of molecular chaperone gene expression in polyglutamine disease | |
| Wynen et al. | Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans | |
| CA2239205A1 (fr) | Prolongation de la duree de vie par surexpression d'un gene qui augmente le metabolisme d'oxygene reactif | |
| Ayajuddin et al. | Parkinson’s disease: Insights from Drosophila model | |
| CA2273173A1 (fr) | Prolongation de la longevite par la surexpression d'un gene qui accroit le metabolisme reactif d'oxygene | |
| Asencio et al. | Coenzyme Q supports distinct developmental processes in Caenorhabditis elegans | |
| Fujikawa et al. | DNA repair dependence of somatic mutagenesis of transposon-caused white alleles in Drosophila melanogaster after treatment with alkylating agents | |
| WO2001018549A1 (fr) | Therapies et reactifs augmentant la resistance au stress et la longevite | |
| Kang et al. | Mitochondrial DNA in somatic cells: a promising target of routine clinical tests | |
| Hanada et al. | Cyclosporin A inhibits thyroid hormone-induced shortening of the tadpole tail through membrane permeability transition | |
| Toivonen et al. | Gene dosage and selective expression modify phenotype in a Drosophila model of human mitochondrial disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |