[go: up one dir, main page]

CA2237998A1 - Chemokine issue du pancreas d'un sujet a diabete non insulinodependant sucre - Google Patents

Chemokine issue du pancreas d'un sujet a diabete non insulinodependant sucre Download PDF

Info

Publication number
CA2237998A1
CA2237998A1 CA002237998A CA2237998A CA2237998A1 CA 2237998 A1 CA2237998 A1 CA 2237998A1 CA 002237998 A CA002237998 A CA 002237998A CA 2237998 A CA2237998 A CA 2237998A CA 2237998 A1 CA2237998 A1 CA 2237998A1
Authority
CA
Canada
Prior art keywords
mcp
expression
sequence
subject
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002237998A
Other languages
English (en)
Inventor
Roger Coleman
Olga Bandman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2237998A1 publication Critical patent/CA2237998A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention concerne un polynucléotide (mcp-4) qui assure l'identification et le codage d'une nouvelle protéine 4 ayant une activité chimiotactique sur les monocytes (MCP-4), exprimée dans les cellules du pancréas d'un sujet à diabète non insulinodépendant sucré. On décrit par ailleurs des molécule antisens, des vecteurs d'expression obtenus par génie génétique ainsi que des cellules hôtes pour la production de MCP-4 purifiées. On décrit aussi des anticorps, des antagonistes et des inhibiteurs assurant spécifiquement la liaison de MCP-4 ainsi que des compositions pharmaceutiques et des procédés de traitement reposant sur le polypeptide considéré, y compris les antagonistes et les inhibiteurs de ce polypeptide. On décrit spécifiquement l'utilisation du polypeptide pour le contrôle positif lié à des tests de diagnostic qui permettent aussi d'identifier l'expression mcp-4 modifiée. Les tests en question font appel à des compositions diagnostiques élaborées à partir de séquences polynucléotidiques à codage mcp-4 ou complémentaires, y compris des oligomères, et à partir d'anticorps anti-MCP-4.
CA002237998A 1995-11-15 1996-11-15 Chemokine issue du pancreas d'un sujet a diabete non insulinodependant sucre Abandoned CA2237998A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US680995P 1995-11-15 1995-11-15
US60/006,809 1995-11-15
US56633495A 1995-12-01 1995-12-01
US08/566,334 1995-12-01

Publications (1)

Publication Number Publication Date
CA2237998A1 true CA2237998A1 (fr) 1997-05-22

Family

ID=26676094

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002237998A Abandoned CA2237998A1 (fr) 1995-11-15 1996-11-15 Chemokine issue du pancreas d'un sujet a diabete non insulinodependant sucre

Country Status (5)

Country Link
EP (1) EP0869972A1 (fr)
JP (1) JP2000500970A (fr)
AU (1) AU7735696A (fr)
CA (1) CA2237998A1 (fr)
WO (1) WO1997018237A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0889961A2 (fr) * 1996-03-27 1999-01-13 Icos Corporation Materiels et procedes de fabrication de proteine-5 chimiotactique monocyte

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014772A1 (fr) * 1993-11-12 1995-06-01 Kenichi Matsubara Signature genique
EP0767796B1 (fr) * 1994-05-16 2001-09-26 Human Genome Sciences, Inc. Proteine chimiotactique
KR970705405A (ko) * 1994-08-23 1997-10-09 벤슨 로버트 에이취 사람 케모킨 폴리펩타이드(Human Chemokine Polypeptides)

Also Published As

Publication number Publication date
EP0869972A1 (fr) 1998-10-14
WO1997018237A1 (fr) 1997-05-22
AU7735696A (en) 1997-06-05
JP2000500970A (ja) 2000-02-02

Similar Documents

Publication Publication Date Title
US20020058241A1 (en) Novel human stem cell antigens
CA2257130A1 (fr) Homologue inhibiteur de proteine kinase-amp cyclique dependante humaine
US5834192A (en) Human cachexia associated protein
WO1998006841A2 (fr) Deux proteines humaines du genre nsp
US5780235A (en) Human voltage-dependent anion channel
US5712115A (en) Human cell death-associated protein
CA2253541A1 (fr) Inhibiteur de la phospholipase chez l'homme
US6238666B1 (en) RANTES homolog antibody
CA2231427A1 (fr) Nouvelle enzyme humaine conjuguant l'ubiquitine
CA2257528A1 (fr) Homologue inhibiteur de proteine kinase c humaine
CA2261573A1 (fr) Nouvelle proteine associee a un gene recepteur de la leptine humaine
US5916556A (en) Human MRNA editing enzyme
US20020034777A1 (en) Novel regulator of cell signaling
CA2237998A1 (fr) Chemokine issue du pancreas d'un sujet a diabete non insulinodependant sucre
US20020034510A1 (en) Novel atpase inhibitor
CA2263165A1 (fr) Proteine de la tumeur induite chez l'homme
EP0958365A1 (fr) Variante de la proteine-2 chimiotactique de granulocytes
WO1998011233A1 (fr) Nouvelle sous-unite gamma de la phosphorylase kinase humaine
CA2263818A1 (fr) Nouvelles proteines de tumeurs
US20020164704A1 (en) Novel human monocyte chemotactic proprotein
CA2270173A1 (fr) Inhibiteur de kazal associe aux tumeurs et homologue de pec-60
US20020155538A1 (en) Novel endothelial growth factor
MXPA98003883A (en) Chemiocine from pancreas de melitus de diabetes that does not depend on insul

Legal Events

Date Code Title Description
FZDE Dead