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CA2226963A1 - Proteines cristallines de la famille zap - Google Patents

Proteines cristallines de la famille zap Download PDF

Info

Publication number
CA2226963A1
CA2226963A1 CA002226963A CA2226963A CA2226963A1 CA 2226963 A1 CA2226963 A1 CA 2226963A1 CA 002226963 A CA002226963 A CA 002226963A CA 2226963 A CA2226963 A CA 2226963A CA 2226963 A1 CA2226963 A1 CA 2226963A1
Authority
CA
Canada
Prior art keywords
atom
zap
protein
ligand
data
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002226963A
Other languages
English (en)
Inventor
Xiaode Lu
Ellen R. Laird
Marcos H. Hatada
Dennis A. Holt
Jennifer L. Karas
Mark J. Zoller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ariad Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2226963A1 publication Critical patent/CA2226963A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne la ZAP-70 de l'homme et, en particulier, la région de ZAP-70 contenant les domaines tandem d'homologie-2 de Src ("SH2"), ses formes cristallines, à ligand ou sans ligand, qui sont particulièrement utiles pour déterminer la structure tridimensionnelle de la protéine. La structure tridimensionnelle de la région tandem de SH2 de la ZAP fournit des informations utiles à la conception de compositions pharmaceutiques inhibant la fonction biologique de la ZAP et d'autres membres de la famille ZAP de protéines contenant les domaines de SH2, en particulier les fonctions biologiques induites par des interactions moléculaires impliquant un ou deux domaines de SH2.
CA002226963A 1995-08-30 1996-08-30 Proteines cristallines de la famille zap Abandoned CA2226963A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US297295P 1995-08-30 1995-08-30
US60/002,972 1995-08-30
US331295P 1995-09-06 1995-09-06
US60/003,312 1995-09-06

Publications (1)

Publication Number Publication Date
CA2226963A1 true CA2226963A1 (fr) 1997-03-06

Family

ID=26671098

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002226963A Abandoned CA2226963A1 (fr) 1995-08-30 1996-08-30 Proteines cristallines de la famille zap

Country Status (6)

Country Link
EP (1) EP0847443A1 (fr)
JP (1) JPH11510061A (fr)
KR (1) KR19990063585A (fr)
AU (1) AU6960696A (fr)
CA (1) CA2226963A1 (fr)
WO (1) WO1997008300A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207397B1 (en) 1996-04-18 2001-03-27 Ariad Pharmaceuticals, Inc. In vitro fluorescence polarization assay
EP0941232A1 (fr) * 1996-11-04 1999-09-15 Merck Frosst Canada Inc. Ligands pour dosage par liaison competitive
US5834228A (en) * 1997-02-13 1998-11-10 Merck & Co., Inc. Method for identifying inhibitors for apopain based upon the crystal structure of the apopain: Ac-DEVD-CHO complex
IL163513A0 (en) * 1998-02-04 2005-12-18 Max Planck Inst For Biochemist A composition containing a tnf-2-converting enzymepolypeptidein crystalline form and methods for thepreparation thereof
US6842704B2 (en) 1998-02-04 2005-01-11 Immunex Corporation Crystalline TNF-α-converting enzyme and uses thereof
WO2002024893A2 (fr) * 2000-09-19 2002-03-28 Chiron Corporation Caracterisation de la proteine gsk-3 $g(b) et ses procedes d'utilisation
JP4731793B2 (ja) 2000-12-28 2011-07-27 アルセア テクノロジーズ インコーポレイテッド 抗体全体またはそのフラグメントの結晶、ならびにこの結晶を作製および使用するための方法
AU2002322295C1 (en) 2001-06-21 2008-12-18 Altus Pharmaceuticals Inc. Spherical protein particles and methods of making and using them
EP1585480A4 (fr) * 2003-01-21 2008-12-03 Smithkline Beecham Corp Co-cristal d'erbb4

Also Published As

Publication number Publication date
EP0847443A1 (fr) 1998-06-17
AU6960696A (en) 1997-03-19
KR19990063585A (ko) 1999-07-26
JPH11510061A (ja) 1999-09-07
WO1997008300A1 (fr) 1997-03-06

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Legal Events

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FZDE Dead