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CA2217990A1 - Ester de carbapenems - Google Patents

Ester de carbapenems Download PDF

Info

Publication number
CA2217990A1
CA2217990A1 CA002217990A CA2217990A CA2217990A1 CA 2217990 A1 CA2217990 A1 CA 2217990A1 CA 002217990 A CA002217990 A CA 002217990A CA 2217990 A CA2217990 A CA 2217990A CA 2217990 A1 CA2217990 A1 CA 2217990A1
Authority
CA
Canada
Prior art keywords
compound
ethyl
methyl
formula
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002217990A
Other languages
English (en)
Inventor
George Burton
Stephen Frederick Moss
Alfred John Eglington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9508955.3A external-priority patent/GB9508955D0/en
Priority claimed from GBGB9508957.9A external-priority patent/GB9508957D0/en
Priority claimed from GBGB9508956.1A external-priority patent/GB9508956D0/en
Application filed by Individual filed Critical Individual
Publication of CA2217990A1 publication Critical patent/CA2217990A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Cette invention concerne un composé correspondant à la formule (I) où R est choisi dans le groupe se composant d'isobutyryloxyméthyle, (5-méthyl-2-oxo-1,3-dioxolèn-4-yl)méthyle et benzoyloxyméthyle, lequel composé est utile dans le traitement d'infections bactériennes.
CA002217990A 1995-05-03 1996-05-02 Ester de carbapenems Abandoned CA2217990A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9508955.3A GB9508955D0 (en) 1995-05-03 1995-05-03 Novel compounds
GBGB9508957.9A GB9508957D0 (en) 1995-05-03 1995-05-03 Novel compounds
GB9508956.1 1995-05-03
GBGB9508956.1A GB9508956D0 (en) 1995-05-03 1995-05-03 Novel compounds
GB9508955.3 1995-05-03
GB9508957.9 1995-05-03

Publications (1)

Publication Number Publication Date
CA2217990A1 true CA2217990A1 (fr) 1996-11-07

Family

ID=27267696

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002217990A Abandoned CA2217990A1 (fr) 1995-05-03 1996-05-02 Ester de carbapenems

Country Status (22)

Country Link
EP (1) EP0823910A1 (fr)
JP (1) JPH11504910A (fr)
KR (1) KR19990008355A (fr)
CN (1) CN1185783A (fr)
AR (1) AR005416A1 (fr)
AU (1) AU5813996A (fr)
BG (1) BG102014A (fr)
BR (1) BR9608313A (fr)
CA (1) CA2217990A1 (fr)
CZ (1) CZ347597A3 (fr)
EA (1) EA199700293A1 (fr)
HU (1) HUP9801066A3 (fr)
IL (1) IL118092A0 (fr)
MA (1) MA23853A1 (fr)
MX (1) MX9708421A (fr)
NO (1) NO974994L (fr)
OA (1) OA10632A (fr)
PE (1) PE50697A1 (fr)
PL (1) PL323141A1 (fr)
SK (1) SK146497A3 (fr)
TR (1) TR199701286T1 (fr)
WO (1) WO1996034868A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2902659A1 (fr) 2006-06-23 2007-12-28 Pierre Fabre Medicament Sa Ester de dha et son utilisation dans le traitement et la prevention des maladies cardiovasculaires
WO2013157583A1 (fr) * 2012-04-18 2013-10-24 大日本住友製薬株式会社 Nouveau composé de carbapénème

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
CA1212105A (fr) * 1980-04-30 1986-09-30 Shoji Ikeda Esters d'ampiciline, et leur production
WO1995005380A1 (fr) * 1993-08-18 1995-02-23 Sankyo Company, Limited Derives cristallins de carbapenem
ES2188621T3 (es) * 1993-10-29 2003-07-01 Smithkline Beecham Plc Derivados de 2-(pirazol-3-il)carbapenem.

Also Published As

Publication number Publication date
AU5813996A (en) 1996-11-21
EP0823910A1 (fr) 1998-02-18
IL118092A0 (en) 1996-09-12
HUP9801066A3 (en) 1999-01-28
MX9708421A (es) 1998-02-28
BG102014A (en) 1998-11-30
WO1996034868A1 (fr) 1996-11-07
MA23853A1 (fr) 1996-12-31
BR9608313A (pt) 1999-01-26
NO974994D0 (no) 1997-10-30
OA10632A (en) 2002-09-16
KR19990008355A (ko) 1999-01-25
PL323141A1 (en) 1998-03-16
CN1185783A (zh) 1998-06-24
TR199701286T1 (xx) 1998-02-21
PE50697A1 (es) 1997-12-18
CZ347597A3 (cs) 1998-08-12
AR005416A1 (es) 1999-06-23
HUP9801066A2 (hu) 1998-08-28
JPH11504910A (ja) 1999-05-11
NO974994L (no) 1997-10-30
EA199700293A1 (ru) 1998-06-25
SK146497A3 (en) 1998-05-06

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Legal Events

Date Code Title Description
FZDE Discontinued