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CA2211458A1 - Production et utilisation de composes de type azole - Google Patents

Production et utilisation de composes de type azole

Info

Publication number
CA2211458A1
CA2211458A1 CA 2211458 CA2211458A CA2211458A1 CA 2211458 A1 CA2211458 A1 CA 2211458A1 CA 2211458 CA2211458 CA 2211458 CA 2211458 A CA2211458 A CA 2211458A CA 2211458 A1 CA2211458 A1 CA 2211458A1
Authority
CA
Canada
Prior art keywords
group
compound
phenyl
triazol
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2211458
Other languages
English (en)
Inventor
Kenji Okonogi
Akihiro Tasaka
Katsumi Itoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2211458A1 publication Critical patent/CA2211458A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un composé de type azole représenté par la formule (I) où Ar est un groupe phényle à substitution optionnelle; R?1¿ et R?2¿, identiques ou différents, sont un atome d'hydrogène ou un groupe alkyle inférieur, ou encore peuvent se combiner entre eux pour former un groupe alkylène inférieur; R?3¿ est un atome d'hydrogène ou un groupe acyle; X est un atome d'azote ou un groupe méthine; A est Y=Z (Y et Z, identiques ou différents, étant un atome d'azote ou un groupe méthine à susbtitution optionnelle par un groupe alkyle inférieur) ou un groupe éthylène à substitution optionnelle par un groupe alkyle inférieur; n est un entier appartenant à la suite allant de 0 à 2; et Az est un groupe azolyle à substitution optionnelle, ou le sel de ce groupe. Ce composé est un agent antifongique, utile pour la prévention et le traitement d'une infection fongique d'un mammifère.
CA 2211458 1995-02-17 1996-02-15 Production et utilisation de composes de type azole Abandoned CA2211458A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2957995 1995-02-17
JP7/29579 1995-02-17
JP7/285318 1995-11-01
JP28531895 1995-11-01

Publications (1)

Publication Number Publication Date
CA2211458A1 true CA2211458A1 (fr) 1996-08-22

Family

ID=26367799

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2211458 Abandoned CA2211458A1 (fr) 1995-02-17 1996-02-15 Production et utilisation de composes de type azole

Country Status (3)

Country Link
AU (1) AU4675596A (fr)
CA (1) CA2211458A1 (fr)
WO (1) WO1996025410A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1251098A (zh) * 1997-03-31 2000-04-19 武田药品工业株式会社 吡咯化合物,其制备及其用途
EP0884311A3 (fr) * 1997-06-06 1999-01-27 Takeda Chemical Industries, Ltd. Dérives de Triazole et procédés pour leur préparation
US6133485A (en) * 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
GB9808447D0 (en) 1998-04-18 1998-06-17 Zeneca Ltd Process
WO2000034267A1 (fr) * 1998-12-04 2000-06-15 Takeda Chemical Industries, Ltd. Procede de production d'un compose d'amide cyclique
US6319933B1 (en) * 2000-04-17 2001-11-20 Basilea Pharmaceutica Ag Azole derivatives
IN192526B (fr) * 2001-09-25 2004-04-24 Ranbaxy Lab
US6884892B2 (en) * 2002-06-20 2005-04-26 Sumitomo Chemical Company, Limited Production methods of epoxytriazole derivative and intermediate therefor
US7141561B2 (en) 2002-07-25 2006-11-28 Sanofi-Aventis Deutschland Gmbh Substituted diaryl heterocycles, process for their preparation and their use as medicaments
DE10233817A1 (de) * 2002-07-25 2004-02-12 Aventis Pharma Deutschland Gmbh Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US10562887B2 (en) 2016-05-27 2020-02-18 Bristol-Myers Squibb Company Triazolones and tetrazolones as inhibitors of ROCK

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW212798B (fr) * 1991-11-25 1993-09-11 Takeda Pharm Industry Co Ltd
TW218017B (fr) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
TW297813B (fr) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
WO1996025410A1 (fr) 1996-08-22
AU4675596A (en) 1996-09-04

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead