CA2202345A1 - 2-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1- one utile comme inhibiteur de la cox-2 - Google Patents

2-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1- one utile comme inhibiteur de la cox-2

Info

Publication number: CA2202345A1
Authority: CA; Canada
Prior art keywords: cyclopenten; phenyl; methylsulfonyl; treatment; difluorophenyl
Prior art date: 1997-03-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002202345A

Other languages

English (en)

Inventor

Cameron Black

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Frosst Canada and Co

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-07

Filing date

1997-04-10

Publication date

1998-09-07

1997-04-10 Application filed by Individual filed Critical Individual

1998-09-07 Publication of CA2202345A1 publication Critical patent/CA2202345A1/fr

Status Abandoned legal-status Critical Current

Links

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LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
230000017105 transposition Effects 0.000 description 1
NHDIQVFFNDKAQU-UHFFFAOYSA-N tripropan-2-yl borate Chemical compound CC(C)OB(OC(C)C)OC(C)C NHDIQVFFNDKAQU-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
239000002753 trypsin inhibitor Substances 0.000 description 1
230000004614 tumor growth Effects 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
201000010653 vesiculitis Diseases 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
239000012224 working solution Substances 0.000 description 1
229960000833 xylometazoline Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CA002202345A 1997-03-07 1997-04-10 2-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1- one utile comme inhibiteur de la cox-2 Abandoned CA2202345A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4004997P	1997-03-07	1997-03-07
US60/040,049		1997-03-07

Publications (1)

Publication Number	Publication Date
CA2202345A1 true CA2202345A1 (fr)	1998-09-07

Family

ID=21908813

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002202345A Abandoned CA2202345A1 (fr)	1997-03-07	1997-04-10	2-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1- one utile comme inhibiteur de la cox-2

Country Status (5)

Country	Link
JP (1)	JPH10251220A (fr)
KR (1)	KR19980078465A (fr)
CA (1)	CA2202345A1 (fr)
IL (1)	IL120671A0 (fr)
PL (1)	PL319742A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR035642A1 (es) *	2000-05-26	2004-06-23	Pharmacia Corp	Uso de una composicion de celecoxib para el alivio rapido del dolor
JP4825667B2 (ja) *	2004-03-31	2011-11-30	一和中尾	関節炎症治療剤又は予防剤

1997
- 1997-04-10 CA CA002202345A patent/CA2202345A1/fr not_active Abandoned
- 1997-04-15 IL IL12067197A patent/IL120671A0/xx unknown
- 1997-04-28 JP JP9111547A patent/JPH10251220A/ja active Pending
- 1997-04-29 PL PL97319742A patent/PL319742A1/xx unknown
- 1997-04-29 KR KR1019970016006A patent/KR19980078465A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
IL120671A0 (en)	1997-08-14
JPH10251220A (ja)	1998-09-22
KR19980078465A (ko)	1998-11-16
PL319742A1 (en)	1998-09-14

Publication	Publication Date	Title
EP0863134A1 (fr)	1998-09-09	2-(3,5-difluorophényle)-3-(4-méthylesulphonylephényle)-2-cyclopentène-1-one comme inhibiteur de la cyclooxygénase-2
EP0912518B1 (fr)	2003-09-10	Pyridines substituees en tant qu'inhibiteurs selectifs de la cyclo-oxygenase-2
EP0828724B1 (fr)	2001-12-05	Diaryl-5-oxygene-2-(5h)-furanones utiles comme inhibiteurs de cox-2
EP1012142B1 (fr)	2004-08-11	Pyridines 2,3,5-trisubstituees utilisees comme inhibiteurs de la cyclo-oxygenase 2
EP0975604B1 (fr)	2004-07-21	Pyridazinones utilises comme inhibiteurs de cyclo-oxygenase-2
US6133292A (en)	2000-10-17	Diaryl-5-alkyl-5-methyl-2-(5H)-furanones as selective cyclooxygenase-2-inhibitors
US6465509B2 (en)	2002-10-15	Pyrones as inhibitors of cyclooxygenase-2
CA2211320C (fr)	2007-03-20	5-methanesulfonamido-3h-isobenzofuran-1-ones utilises comme inhibiteurs de cyclooxygenase-2
EP0970067B1 (fr)	2003-07-02	(methylsufonyl)phenyl-2-(5h)-furanones a liaison oxygene, utilisees comme inhibiteurs de cyclo-oxygenase-2
AU2001268881A1 (en)	2002-04-11	Pyrones as inhibitors of cyclooxygenase-2
AU710675B2 (en)	1999-09-30	Alkylated styrenes as prodrugs to COX-2 inhibitors
US6071954A (en)	2000-06-06	(methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors
AU6818298A (en)	1998-10-22	Alpha-methylene gamma lactones as selective cyclooxygenase-2 inhibitors
AU741790B2 (en)	2001-12-06	Diaryl-5-alkyl-5-methyl-2(5H)-furanones as selective cyclooxygenase-2 inhibitors
EP1015431B1 (fr)	2005-04-20	2-aminopyridines utilisees comme inhibiteurs de la cyclo-oxygenase 2
WO1997028120A1 (fr)	1997-08-07	Stilbenes de diphenyle utilises en tant que promedicaments d'inhibiteurs de cox-2
US6004960A (en)	1999-12-21	Pyridazinones as inhibitors of cyclooxygenase-2
US6004950A (en)	1999-12-21	2-aminopyridines as inhibitors of cyclooxygenase-2
CA2202345A1 (fr)	1998-09-07	2-(3,5-difluorophenyl)-3-(4-(methylsulfonyl)phenyl)-2-cyclopenten-1- one utile comme inhibiteur de la cox-2
CA2252401C (fr)	2004-02-17	Pyridinyl-2-cyclopenten-1-ones utilisees comme inhibiteurs de cyclooxygenase selectifs
AU741981B2 (en)	2001-12-13	(Methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as cox-2 inhibitors

Legal Events

Date	Code	Title	Description
2002-03-26	EEER	Examination request
2005-04-11	FZDE	Discontinued