[go: up one dir, main page]

CA2291647A1 - Antagonistes de la gonadoliberine - Google Patents

Antagonistes de la gonadoliberine Download PDF

Info

Publication number
CA2291647A1
CA2291647A1 CA002291647A CA2291647A CA2291647A1 CA 2291647 A1 CA2291647 A1 CA 2291647A1 CA 002291647 A CA002291647 A CA 002291647A CA 2291647 A CA2291647 A CA 2291647A CA 2291647 A1 CA2291647 A1 CA 2291647A1
Authority
CA
Canada
Prior art keywords
substituted
alkyl
aryl
compound
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002291647A
Other languages
English (en)
Inventor
Mark Goulet
Feroze Ujjainwalla
Thomas F. Walsh
Matthew J. Wyvratt, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9716865.2A external-priority patent/GB9716865D0/en
Priority claimed from GBGB9719391.6A external-priority patent/GB9719391D0/en
Application filed by Individual filed Critical Individual
Publication of CA2291647A1 publication Critical patent/CA2291647A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention porte sur des composés de formule (I) et leurs sels pharmacocompatibles servant d'antagonistes de l'hormone GnRH et utiles à ce titre dans le traitement d'états liés aux hormones sexuelles chez l'homme et chez la femme.
CA002291647A 1997-06-05 1998-06-01 Antagonistes de la gonadoliberine Abandoned CA2291647A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US4874397P 1997-06-05 1997-06-05
US4863597P 1997-06-05 1997-06-05
US60/048,635 1997-06-05
US60/048,743 1997-06-05
GBGB9716865.2A GB9716865D0 (en) 1997-08-08 1997-08-08 Antagonists of gonadotrophin releasing hormone
GB9716865.2 1997-08-08
GBGB9719391.6A GB9719391D0 (en) 1997-09-11 1997-09-11 Antagonists of gonadotropin releasing hormone
GB9719391.6 1997-09-11
PCT/US1998/011072 WO1998055479A1 (fr) 1997-06-05 1998-06-01 Antagonistes de la gonadoliberine

Publications (1)

Publication Number Publication Date
CA2291647A1 true CA2291647A1 (fr) 1998-12-10

Family

ID=27451687

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002291647A Abandoned CA2291647A1 (fr) 1997-06-05 1998-06-01 Antagonistes de la gonadoliberine

Country Status (5)

Country Link
EP (1) EP0986557A4 (fr)
JP (1) JP2002502422A (fr)
AU (1) AU729663B2 (fr)
CA (1) CA2291647A1 (fr)
WO (1) WO1998055479A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346534B1 (en) 1998-09-23 2002-02-12 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
US6537998B1 (en) 1999-10-15 2003-03-25 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
DK1255738T3 (da) 2000-01-25 2012-06-25 Neurocrine Biosciences Inc Gonadotropin-frigivende hormonreceptor-antagonister og fremgangsmåder relateret dertil
JP2002080397A (ja) * 2000-07-05 2002-03-19 Takeda Chem Ind Ltd 性ホルモン依存性疾患の治療用医薬製剤
GB0022670D0 (en) 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
SE0100566D0 (sv) 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
SE0101692D0 (sv) 2001-05-14 2001-05-14 Astrazeneca Ab Compounds
US6740656B2 (en) 2001-08-02 2004-05-25 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
MXPA04000985A (es) 2001-08-02 2005-02-17 Neurocrine Biosciences Inc Piridin-4-onas sustituidas y su uso como antagonistas del receptor de hormona de liberacion de gonadotropina.
JP2005500352A (ja) 2001-08-02 2005-01-06 ニューロクライン バイオサイエンシーズ， インコーポレイテッド ゴナドトロピン放出ホルモンレセプター（ＧｎＲＨ）アンタゴニストとしての１，２，４−トリアジン−３，５−ジオン
US6750350B2 (en) 2001-08-02 2004-06-15 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
AU2002324586B2 (en) 2001-08-02 2008-04-24 Neurocrine Biosciences, Inc. 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists
AU2003267551A1 (en) 2002-08-21 2004-03-11 Astrazeneca Ab Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone
GB0219472D0 (en) 2002-08-21 2002-10-02 Astrazeneca Ab Chemical compounds
TW200407127A (en) 2002-08-21 2004-05-16 Astrazeneca Ab Chemical compounds
DE60314158T2 (de) 2002-08-21 2008-01-31 Astrazeneca Ab Pyrazolderivate als gnrh-inhibitoren
TW200413351A (en) 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
WO2005007165A1 (fr) 2003-07-07 2005-01-27 Neurocrine Biosciences, Inc. Derives de pyrimidine-2, 4-dione utilises comme antagonistes du recepteur d'hormone liberant de la gonadotrophine
ATE557007T1 (de) 2003-07-07 2012-05-15 Neurocrine Biosciences Inc Arylpyrimidine geeignet zur behandlung von sexualhormonbedingten zuständen wie endometriose, prostatakrebs und dergleichen
DE602004020638D1 (de) 2003-07-07 2009-05-28 Neurocrine Biosciences Inc Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
DE102004033902A1 (de) 2004-07-14 2006-02-16 Zentaris Gmbh Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
WO2007047397A2 (fr) 2005-10-13 2007-04-26 Smithkline Beecham Corporation Nouveaux composes heterocycliques
EP2095818A1 (fr) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Utilisation d'antagonistes LHRH dans des doses n'impliquant pas de castration
TW201130854A (en) 2009-12-22 2011-09-16 Bayer Schering Pharma Ag Pyridinone derivatives and pharmaceutical compositions thereof
WO2012175514A1 (fr) 2011-06-21 2012-12-27 Bayer Intellectual Property Gmbh Dérivés de pyridinone et compositions pharmaceutiques les contenant
EP3185881B1 (fr) 2014-08-26 2022-03-09 Betanien Hospital Méthodes, agents et compositions pour le traitement d'états inflammatoires
CN120365272A (zh) 2018-10-05 2025-07-25 安娜普尔纳生物股份有限公司 用于治疗与apj受体活性有关的疾病的化合物和组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW449600B (en) * 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
EA000992B1 (ru) * 1995-12-14 2000-08-28 Мерк Энд Ко., Инк. Антагонисты гормона, высвобождающего гонадотропин
HUP9902121A3 (en) * 1995-12-14 2001-05-28 Merck & Co Inc Indole derivatives as antagonists of gonadotropin releasing hormone and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
WO1998055479A1 (fr) 1998-12-10
JP2002502422A (ja) 2002-01-22
EP0986557A1 (fr) 2000-03-22
AU7605698A (en) 1998-12-21
AU729663B2 (en) 2001-02-08
EP0986557A4 (fr) 2001-03-14

Similar Documents

Publication Publication Date Title
AU728988B2 (en) Antagonists of gonadotropin releasing hormone
EP0873336B1 (fr) Antagonistes de l'hormone de liberation de la gonadotropine
AU729752B2 (en) Antagonists of gonadotropin releasing hormone
AU729663B2 (en) Antagonists of gonadotropin releasing hormone
US6156772A (en) Antagonists of gonadotropin releasing hormone
EP1011667A1 (fr) Antagonistes de l'hormone de liberation de la gonadotrophine
EP1095038B1 (fr) Antagonistes de la gonadoliberine
US5981550A (en) Antagonists of gonadotropin releasing hormone
CA2308454A1 (fr) Antagonistes de l'hormone de liberation de la gonadothrophine
CA2308069A1 (fr) Antagonistes de la gonadoliberine
US6156767A (en) Antagonists of gonadotropin releasing hormone
US6004984A (en) Antagonists of gonadotropin releasing hormone
CA2318957A1 (fr) Antagonistes de l'hormone de liberation de la gonadotrophine
CA2317451A1 (fr) Antagonistes de l'hormone de liberation de la gonadotrophine
AU728811B2 (en) Antagonists of gonadotropin releasing hormone
US5985901A (en) Antagonists of gonadotropin releasing hormone
US6159975A (en) Antagonists of gonadotropin releasing hormone

Legal Events

Date Code Title Description
FZDE Dead